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DYNLL1 [plasma membrane]
Stable Identifier
R-HSA-54017
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
DLC1, Dynein light chain 1, cytoplasmic, 8 kDa dynein light chain, DLC8, Protein inhibitor of neuronal nitric oxide synthase, PIN
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule membrane proteins (Homo sapiens)
Ficolin-rich granule membrane proteins [plasma membrane] (Homo sapiens)
DYNLL1 [plasma membrane] (Homo sapiens)
Exocytosis of tertiary granule membrane proteins (Homo sapiens)
Tertiary granule membrane proteins [plasma membrane] (Homo sapiens)
DYNLL1 [plasma membrane] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Activation of BH3-only proteins (Homo sapiens)
Activation of BIM and translocation to mitochondria (Homo sapiens)
Phosphorylation of BIM by JNK (Homo sapiens)
BIM sequestered to dynein (DLC1) [plasma membrane] (Homo sapiens)
DYNLL1 [plasma membrane] (Homo sapiens)
Dynein (DLC1) on microtubules [plasma membrane] (Homo sapiens)
DYNLL1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P63167 DYNLL1
Gene Names
DYNLL1, DLC1, DNCL1, DNCLC1, HDLC1
Chain
chain:1-89
Reference Genes
BioGPS Gene:8655 DYNLL1
COSMIC (genes):DYNLL1 DYNLL1
CTD Gene:8655 DYNLL1
dbSNP Gene:8655 DYNLL1
ENSEMBL:ENSG00000088986 DYNLL1
ENSEMBL_homo_sapiens_GENE:ENSG00000088986.11 DYNLL1
HGNC:15476 DYNLL1
KEGG Gene (Homo sapiens):8655 DYNLL1
Monarch:8655 DYNLL1
NCBI Gene:8655 DYNLL1
OMIM:601562 DYNLL1
Reference Transcript
RefSeq:NM_001037494.1 DYNLL1
RefSeq:NM_003746.2 DYNLL1
RefSeq:NM_001037495.1 DYNLL1
Other Identifiers
11753833_a_at
200703_PM_at
200703_at
3059785
3434394
3434396
3434398
3434402
3434403
3434404
3434407
3434408
3434409
3434410
34891_at
3574114
3574116
7959164
7980535
8655
A_23_P65031
A_24_P124672
GE61176
GO:0000776
GO:0004857
GO:0005515
GO:0005634
GO:0005694
GO:0005737
GO:0005739
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005868
GO:0005874
GO:0005875
GO:0005886
GO:0005929
GO:0006915
GO:0007005
GO:0007017
GO:0007018
GO:0007286
GO:0008180
GO:0012501
GO:0015630
GO:0016020
GO:0019899
GO:0019904
GO:0021762
GO:0022414
GO:0023052
GO:0030141
GO:0030154
GO:0030235
GO:0030286
GO:0031410
GO:0035721
GO:0035774
GO:0042326
GO:0042802
GO:0043226
GO:0044458
GO:0044782
GO:0044877
GO:0045019
GO:0045505
GO:0048856
GO:0051881
GO:0070821
GO:0072686
GO:0097110
GO:0097542
GO:0098772
GO:0101003
GO:0160040
GO:1902857
GO:1904115
HMNXSV003054414
ILMN_2300186
PH_hs_0035324
U32944_at
g4505812_3p_at
Participates
as a member of
Ficolin-rich granule membrane proteins [plasma membrane] (Homo sapiens)
Tertiary granule membrane proteins [plasma membrane] (Homo sapiens)
as a component of
Dynein (DLC1) on microtubules [plasma membrane] (Homo sapiens)
BIM sequestered to dynein (DLC1) [plasma membrane] (Homo sapiens)
Other forms of this molecule
DYNLL1 [ciliary tip]
DYNLL1 [cytosol]
DYNLL1 [tertiary granule membrane]
DYNLL1 [ficolin-1-rich granule membrane]
DYNLL1 [cilium]
Inferred To
dynll1 [plasma membrane]
(Xenopus tropicalis)
dlc-4 [plasma membrane]
(Caenorhabditis elegans)
Homologues of DYNLL1 [plasma membrane]
(Caenorhabditis elegans)
Homologues of DYNLL1 [plasma membrane]
(Drosophila melanogaster)
Homologues of DYNLL1 [plasma membrane]
(Plasmodium falciparum)
dlc-6 [plasma membrane]
(Caenorhabditis elegans)
dlc-1 [plasma membrane]
(Caenorhabditis elegans)
Cdlc2 [plasma membrane]
(Drosophila melanogaster)
dlc-3 [plasma membrane]
(Caenorhabditis elegans)
dlc2 [plasma membrane]
(Schizosaccharomyces pombe)
ctp [plasma membrane]
(Drosophila melanogaster)
dlc-5 [plasma membrane]
(Caenorhabditis elegans)
Dynll1 [plasma membrane]
(Mus musculus)
Dynll1 [plasma membrane]
(Rattus norvegicus)
DYN2 [plasma membrane]
(Saccharomyces cerevisiae)
DYNLL1 [plasma membrane]
(Bos taurus)
DYNLL1 [plasma membrane]
(Canis familiaris)
DYNLL1 [plasma membrane]
(Gallus gallus)
DYNLL1 [plasma membrane]
(Plasmodium falciparum)
DYNLL1 [plasma membrane]
(Sus scrofa)
dlcB [plasma membrane]
(Dictyostelium discoideum)
dlc-2 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001032583.1
,
NP_001032584.1
,
NP_003737.1
OpenTargets
ENSG00000088986
HPA
ENSG00000088986-DYNLL1
GeneCards
P63167
Ensembl
ENST00000392508
,
ENST00000242577
,
ENST00000392509
,
ENSP00000447907
,
ENST00000548342
,
ENSP00000242577
,
ENSP00000446614
,
ENSP00000376296
,
ENST00000549989
,
ENSG00000088986
,
ENSP00000376297
PRO
P63167
Pharos - Targets
P63167
HMDB Protein
HMDBP10685
PDB
6SC2
,
6RLB
,
7D35
,
6GZL
,
3ZKF
,
6GZJ
,
3ZKE
,
1CMI
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13153 PAK1
5
PAK1 [plasma membrane]
(R-HSA-3928409)
p-S144,T423-PAK1 [plasma membrane]
(R-HSA-3928472)
Active PAK1 [cytosol]
(R-HSA-8964622)
PAK1 [cytosol]
(R-HSA-162629)
p-S144,T423-PAK1 [cytosol]
(R-HSA-399819)
0.666
4
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
10
UniProt:Q13627 DYRK1A
1
DYRK1A [nucleoplasm]
(R-HSA-1362267)
0.659
3
UniProt:P63244 RACK1
1
GNB2L1 [cytosol]
(R-HSA-5626956)
0.632
6
UniProt:Q96LC9 BMF
3
p-BMF [mitochondrial outer membrane]
(R-HSA-3145026)
BMF [plasma membrane]
(R-HSA-140209)
p-BMF(1-89) [cytosol]
(R-HSA-140529)
0.556
3
UniProt:O96015 DNAL4
1
DNAL4 [plasma membrane]
(R-HSA-177484)
0.556
3
UniProt:Q6W0C5 DPPA3
2
DPPA3 [cytosol]
(R-HSA-9818458)
DPPA3 [nucleoplasm]
(R-HSA-9817479)
0.556
5
UniProt:Q9Y6E0 STK24
4
STK24(1-313) [nucleoplasm]
(R-HSA-351944)
STK24(314-443) [cytosol]
(R-HSA-351898)
STK24(1-313) [cytosol]
(R-HSA-351892)
STK24 [cytosol]
(R-HSA-351829)
0.527
2
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
4
UniProt:Q16656 NRF1
1
NRF1 [nucleoplasm]
(R-HSA-1592205)
0.508
2
UniProt:Q9NR28 DIABLO
2
DIABLO [mitochondrial intermembrane space]
(R-HSA-64637)
DIABLO [cytosol]
(R-HSA-114298)
0.508
2
UniProt:Q9C0C7 AMBRA1
2
p-AMBRA1 [cytosol]
(R-HSA-1632854)
AMBRA1 [cytosol]
(R-HSA-1632831)
0.508
2
UniProt:P98170 XIAP
3
XIAP [nucleoplasm]
(R-HSA-3322366)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [cytosol]
(R-HSA-50849)
0.508
2
UniProt:Q14677 CLINT1
1
CLINT1 [cytosol]
(R-HSA-429811)
0.508
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
8
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