SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol]

Stable Identifier
R-HSA-9711954
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Sequestosome-1, SQSTM_HUMAN
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
21134980 Identification of a novel fusion, SQSTM1-ALK, in ALK-positive large B-cell lymphoma

Ota, Y, Soda, M, Togashi, Y, Hatano, S, Noguchi, M, Takeuchi, K, Mano, H, Asaka, R, Sekiguchi, Y

Haematologica 2011
25813404 Novel ALK fusion partners in lung cancer

Pozharisski, KM, Aleksakhina, SN, Imyanitov, EN, Togo, AV, Sokolenko, AP, Ivantsov, AO, Mitiushkina, NV, Merkulov, VO, Strelkova, TN, Iyevleva, AG, Garifullina, AR, Tiurin, VI, Kuligina, ESh, Raskin, GA

Cancer Lett 2015
External Reference Information
External Reference
Gene Names
SQSTM1, ORCA, OSIL
Chain
initiator methionine:, chain:2-440, initiator methionine:
Other Identifiers
11717290_s_at
11727031_a_at
11745754_x_at
11752843_x_at
11756761_x_at
16993458
201471_PM_s_at
201471_s_at
213112_PM_s_at
213112_s_at
2844499
2844500
2844505
2844506
2844507
2844508
2844509
2844512
2844513
2844514
2844515
2844516
2844518
2844523
2844524
2844528
2844529
2844535
2844536
2844537
2844538
2844539
2844540
2844541
2844542
40898_at
8110569
8878
A_14_P109999
A_23_P81399
GE79794
GO:0000122
GO:0000407
GO:0000422
GO:0000423
GO:0000425
GO:0000932
GO:0001659
GO:0001934
GO:0002376
GO:0002931
GO:0005080
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005764
GO:0005768
GO:0005770
GO:0005773
GO:0005776
GO:0005783
GO:0005829
GO:0005929
GO:0006351
GO:0006355
GO:0006366
GO:0006511
GO:0006606
GO:0006886
GO:0006913
GO:0006914
GO:0006915
GO:0007005
GO:0007032
GO:0008104
GO:0008270
GO:0010508
GO:0010821
GO:0012501
GO:0016192
GO:0016197
GO:0016234
GO:0016235
GO:0016236
GO:0016605
GO:0019899
GO:0019901
GO:0023052
GO:0030017
GO:0030154
GO:0030163
GO:0030674
GO:0030971
GO:0031397
GO:0031410
GO:0031625
GO:0034144
GO:0035255
GO:0035556
GO:0035591
GO:0035973
GO:0036211
GO:0038023
GO:0042169
GO:0042802
GO:0043065
GO:0043122
GO:0043130
GO:0043226
GO:0043231
GO:0043232
GO:0044753
GO:0044754
GO:0044877
GO:0045944
GO:0046578
GO:0046872
GO:0060089
GO:0060090
GO:0061635
GO:0070062
GO:0070342
GO:0070530
GO:0071211
GO:0072659
GO:0097009
GO:0097225
GO:0097413
GO:0098542
GO:0098780
GO:0140036
GO:0140311
GO:0140313
GO:0140693
GO:0140694
GO:1900273
GO:1903078
GO:1905719
HMNXSV003033729
Hs.279891.1.A1_3p_at
ILMN_1662618
PH_hs_0010763
U46751_at
g4505570_3p_s_at
Participates
Other forms of this molecule
Modified Residues
Name
Insertion of residues 1058 to 1620 at 252 from UniProt:Q9UM73 ALK
Coordinate
252
Disease
Name Identifier Synonyms
diffuse large B-cell lymphoma DOID:0050745
lung adenocarcinoma DOID:3910 nonsmall cell adenocarcinoma
Interactors (59)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9GZQ8 MAP1LC3B  3 0.978 31
 UniProt:P60520 GABARAPL2  3 0.97 25
 UniProt:Q14145 KEAP1  3 0.968 21
 UniProt:Q9H0R8 GABARAPL1  3 0.953 18
 UniProt:Q9H492 MAP1LC3A  3 0.951 16
 UniProt:O95166 GABARAP  3 0.948 17
 UniProt:Q9BXW4 MAP1LC3C  3 0.901 8
 UniProt:P41743 PRKCI  3 0.894 11
 UniProt:Q13501 SQSTM1  7 0.888 10
 IntAct:EBI-4399559 UBIQ      0.829 6
 UniProt:P0CG48 UBC  20 0.806 5
 UniProt:Q16543 CDC37  1 0.801 8
 UniProt:Q14596 NBR1  2 0.775 7
 UniProt:P42858 HTT  1 0.771 11
 UniProt:P58004 SESN2  1 0.728 9
 UniProt:Q05513 PRKCZ  5 0.725 6
 UniProt:Q8IZQ1 WDFY3      0.709 7
 UniProt:Q9Y4K3 TRAF6  8 0.688 4
 UniProt:Q5S007 LRRK2  1 0.67 18
 UniProt:Q15038 DAZP2      0.666 4
 UniProt:P54253 ATX1      0.666 4
 UniProt:P07437 TUBB  3 0.666 4
 UniProt:Q13163 MAP2K5  1 0.666 5
 UniProt:Q9BPW8 NIPS1      0.65 3
 UniProt:P54725 RAD23A  1 0.635 3
 UniProt:P11473 VDR  2 0.591 4
 UniProt:Q6IRU7  1 0.564 2
 UniProt:Q96CV9 OPTN  6 0.558 7
 UniProt:Q9UGJ0 PRKAG2  2 0.556 3
 UniProt:O14682 ENC1      0.556 7
 UniProt:O14576-2 O145762      0.556 3
 UniProt:Q9UBQ0-2 VPS29      0.556 3
 UniProt:P34972 CNR2  1 0.556 5
 UniProt:P19544-6 WT1      0.556 3
 UniProt:P12709  4 0.556 3
 UniProt:A8K2U6 A8K2U6      0.556 3
 IntAct:EBI-25830852 RZPDO839G03145      0.556 3
 UniProt:P17028 ZNF24      0.556 3
 UniProt:P0DMV8 HSPA1A  4 0.556 3
 UniProt:P37840 SNCA  5 0.556 3
 UniProt:P05067 APP  20 0.556 6
 UniProt:Q9UNE7 STUB1  1 0.556 3
 UniProt:Q2V2M9 FHOD3      0.543 6
 UniProt:Q2V2M9-4 FHOD3      0.543 4
 UniProt:P84022 SMAD3  20 0.543 3
 UniProt:O95817 BAG3  1 0.537 3
 UniProt:P57739 CLDN2  2 0.537 4
 UniProt:Q15334 L2GL1      0.527 2
 UniProt:O15530 PDPK1  2 0.527 3
 UniProt:P16070 CD44  2 0.527 2
 UniProt:Q9Y6K9 IKBKG  12 0.524 2
 UniProt:Q9UDY8 MALT1  1 0.524 2
 UniProt:Q96B97 SH3KBP1  3 0.524 4
 UniProt:P38182  12 0.508 3
 UniProt:P12504 VIF      0.499 2
 UniProt:P04629 NTRK1  4 0.499 2
 UniProt:O70405  7 0.499 2
 UniProt:Q9NX00 TM160      0.483 2
 UniProt:P13569 CFTR  17 0.483 14
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