Reactome | ESYT2 [endoplasmic reticulum membrane]

ESYT2 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-8857683

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Extended synaptotagmin-2, ESYT2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:A0FGR8 ESYT2

Gene Names

ESYT2, FAM62B, KIAA1228

Chain

chain:1-921

Reference Genes

BioGPS Gene:57488 ESYT2

COSMIC (genes):ESYT2 ESYT2

CTD Gene:57488 ESYT2

dbSNP Gene:57488 ESYT2

ENSEMBL:ENSG00000117868 ESYT2

HGNC:22211 ESYT2

KEGG Gene (Homo sapiens):57488 ESYT2

Monarch:57488 ESYT2

NCBI Gene:57488 ESYT2

UCSC:A0FGR8 ESYT2

Reference Transcript

RefSeq:NM_020728.2 ESYT2

Other Identifiers

0000360458

0003830711

11721313_a_at

11721314_at

1555830_s_at

1558511_s_at

17064984

224698_3p_at

224698_at

224699_s_at

3082250

3082251

3082252

3082253

3082254

3082256

3082258

3082259

3082262

3082263

3082264

3082265

3082266

3082271

3082275

3082277

3082278

3082286

3082287

3082288

3082289

3082291

3082294

3082295

3082301

3082302

3082306

3082308

3082309

3082318

3082319

3082320

3082321

3082322

3082323

56288_at

57488

59648_at

63801_at

8144184

A_23_P8744

A_24_P132470

GE80288

GO:0003674

GO:0005509

GO:0005515

GO:0005544

GO:0005575

GO:0005622

GO:0005737

GO:0005783

GO:0005789

GO:0005886

GO:0005887

GO:0006629

GO:0006687

GO:0006810

GO:0006869

GO:0006897

GO:0008150

GO:0008289

GO:0008429

GO:0016020

GO:0016021

GO:0016192

GO:0031210

GO:0031227

GO:0031234

GO:0035091

GO:0042802

GO:0043167

GO:0043226

GO:0044232

GO:0045296

GO:0046872

GO:0061817

GO:0140268

HMNXSV003011517

Hs.267690.1.A1_3p_s_at

Hs.267690.1.A2_3p_x_at

Hs2.407397.1.A1_3p_s_at

Hs2Affx.1.469.A1_3p_s_at

ILMN_1807761

ILMN_2057573

PH_hs_0024446

TC07002084.hg

Participates

as a component of

ESYT1:ESYT2:ESYT3 [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

ESYT2 [endoplasmic reticulum membrane] (Canis familiaris)

ESYT2 [endoplasmic reticulum membrane] (Gallus gallus)

ESYT2 [endoplasmic reticulum membrane] (Sus scrofa)

esyt-2 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

Esyt2 [endoplasmic reticulum membrane] (Mus musculus)

Esyt2 [endoplasmic reticulum membrane] (Rattus norvegicus)

esyt2b [endoplasmic reticulum membrane] (Danio rerio)

Cross References

RefSeq

NP_065779.1

OpenTargets

ENSG00000117868

HPA

ENSG00000117868-ESYT2

GeneCards

A0FGR8

Ensembl

ENST00000652148, ENSP00000499020, ENSG00000117868

PRO

A0FGR8

Pharos - Targets

A0FGR8

GlyGen

A0FGR8

HMDB Protein

HMDBP07672

PDB

4NPJ, 4NPK, 2DMG, 4P42

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	4