Reactome | TUBG2 [cytosol]

TUBG2 [cytosol]

Stable Identifier

R-HSA-379272

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

gamma-2- tubulin

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - Recruitment of NuMA to mitotic centrosomes (Homo sapiens)
        
        Association of NuMA with microtubules (Homo sapiens)
        
        Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        gamma-TuSC [cytosol] (Homo sapiens)
        
        TUBG2 [cytosol] (Homo sapiens)
        
        p-T2055-NUMA1 homodimer:Mature centrosome:nucleated microtubules [cytosol] (Homo sapiens)
        
        Mature centrosome:nucleated microtubules [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        gamma-TuSC [cytosol] (Homo sapiens)
        
        TUBG2 [cytosol] (Homo sapiens)
        
        Translocation of NuMA to the centrosomes (Homo sapiens)
        
        Mature centrosome enriched in gamma-TURC:p-T2055-NUMA1 homodimer [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        gamma-TuSC [cytosol] (Homo sapiens)
        
        TUBG2 [cytosol] (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        gamma-TuSC [cytosol] (Homo sapiens)
        
        TUBG2 [cytosol] (Homo sapiens)
  - Mitotic G2-G2/M phases (Homo sapiens)
    - G2/M Transition (Homo sapiens)
      - Centrosome maturation (Homo sapiens)
        
        Recruitment of mitotic centrosome proteins and complexes (Homo sapiens)
        
        Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome (Homo sapiens)
        
        Mature centrosomes enriched in gamma-TURC complexes [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        gamma-TuSC [cytosol] (Homo sapiens)
        
        TUBG2 [cytosol] (Homo sapiens)
        
        gamma-tubulin complex [cytosol] (Homo sapiens)
        
        gamma-TuSC [cytosol] (Homo sapiens)
        
        TUBG2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NRH3 TUBG2

Gene Names

TUBG2

Chain

chain:1-451

Reference Genes

BioGPS Gene:27175 TUBG2

COSMIC (genes):TUBG2 TUBG2

CTD Gene:27175 TUBG2

dbSNP Gene:27175 TUBG2

ENSEMBL:ENSG00000037042 TUBG2

ENSEMBL_homo_sapiens_GENE:ENSG00000037042.9 TUBG2

HGNC:12419 TUBG2

KEGG Gene (Homo sapiens):27175 TUBG2

Monarch:27175 TUBG2

NCBI Gene:27175 TUBG2

OMIM:605785 TUBG2

UCSC:Q9NRH3 TUBG2

Reference Transcript

RefSeq:NM_016437.2 TUBG2

Other Identifiers

11720615_a_at

11756463_x_at

16834395

203894_PM_at

203894_at

27175

2999627

2999637

3721930

3721938

3721941

3721943

3721957

3721958

3721960

3721961

3721963

3721969

3721970

3721972

3721973

3721974

3721976

3721979

3721980

3721982

3721983

3721984

8007312

A_23_P78014

GE58008

GO:0000070

GO:0000166

GO:0000212

GO:0000242

GO:0000278

GO:0000930

GO:0005198

GO:0005200

GO:0005525

GO:0005634

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0005874

GO:0005876

GO:0005881

GO:0007010

GO:0007017

GO:0007020

GO:0007052

GO:0007059

GO:0015630

GO:0022414

GO:0031122

GO:0043226

GO:0065003

GO:0140014

HMNXSV003049861

ILMN_1701052

ILMN_1728024

PH_hs_0014380

TC17000532.hg

g7706750_3p_at

Participates

as a component of

gamma-TuSC [cytosol] (Homo sapiens)

Inferred To

Tubg2 [cytosol] (Rattus norvegicus)

TUBG2 [cytosol] (Bos taurus)

TUBG2 [cytosol] (Mus musculus)

TUBG2 [cytosol] (Sus scrofa)

TUBG1 [cytosol] (Gallus gallus)

LOC100856176 [cytosol] (Canis familiaris)

tubg1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_057521.1

OpenTargets

ENSG00000037042

HPA

ENSG00000037042-TUBG2

GeneCards

Q9NRH3

Ensembl

ENSP00000251412, ENST00000251412, ENSG00000037042

PRO

Q9NRH3

Pharos - Targets

Q9NRH3

Orphanet

26307

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	4