Reactome | ACSL3 [endoplasmic reticulum membrane]

ACSL3 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-548787

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Long-chain-fatty-acid--CoA ligase 3

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O95573 ACSL3

Gene Names

ACSL3, ACS3, FACL3, LACS3

Chain

chain:1-720

Reference Genes

BioGPS Gene:2181 ACSL3

COSMIC (genes):ACSL3 ACSL3

CTD Gene:2181 ACSL3

dbSNP Gene:2181 ACSL3

ENSEMBL:ENSG00000123983 ACSL3

HGNC:3570 ACSL3

KEGG:hsa:2181 ACSL3

Monarch:2181 ACSL3

NCBI Gene:2181 ACSL3

OMIM:602371 ACSL3

UCSC:O95573 ACSL3

Reference Transcript

Other Identifiers

11739261_s_at

11743606_a_at

16891575

201660_PM_at

201660_at

201661_PM_s_at

201661_s_at

201662_PM_s_at

201662_s_at

2181

236168_PM_at

236168_at

242726_PM_at

242726_at

2529547

2529552

2529555

2529562

2529563

2529564

2529565

2529566

2529567

2529568

2529569

2529570

2529571

2529572

2529573

2529574

2529575

2529576

2529577

2529578

2529579

2529580

2529581

2529582

2529583

2529584

2529585

2529587

2529588

2529589

2529590

2529591

2529592

2529593

2529594

2529595

2529596

2529597

2529598

33880_at

33881_at

42670_at

50846_at

8048733

86030_at

A_14_P113792

A_24_P248606

A_24_P37319

GE81398

GO:0000166

GO:0001676

GO:0003824

GO:0004467

GO:0005515

GO:0005524

GO:0005739

GO:0005741

GO:0005777

GO:0005778

GO:0005783

GO:0005789

GO:0005794

GO:0005811

GO:0005886

GO:0006629

GO:0006631

GO:0006790

GO:0016020

GO:0016874

GO:0019901

GO:0019904

GO:0030154

GO:0030182

GO:0031956

GO:0034379

GO:0035336

GO:0035338

GO:0042998

GO:0043226

GO:0044539

GO:0047676

GO:0048471

GO:0051047

GO:0055086

GO:0065003

GO:0090433

GO:0140657

GO:1901135

GO:2001247

HMNXSV003023160

Hs.122365.0.A1_3p_at

Hs.193385.0.A1_3p_at

Hs.268012.0.S3_3p_at

ILMN_1654414

ILMN_1666096

ILMN_2360705

PH_hs_0013723

TC02001350.hg

g12669907_3p_a_at

g4165017_3p_a_at

Participates

as a member of

ACSL1,3,5,6 [endoplasmic reticulum membrane] (Homo sapiens)

as a candidate of

ACSL3,4 [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

ACSL3 [mitochondrial outer membrane]

Inferred To

Acsl3 [endoplasmic reticulum membrane] (Mus musculus)

Acsl3 [endoplasmic reticulum membrane] (Rattus norvegicus)

Homologues of ACSL3 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

Homologues of ACSL3 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

Homologues of ACSL3 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

acs-4 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

Acsl [endoplasmic reticulum membrane] (Drosophila melanogaster)

acsl3b [endoplasmic reticulum membrane] (Danio rerio)

acs-17 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

ACSL3 [endoplasmic reticulum membrane] (Bos taurus)

ACSL3 [endoplasmic reticulum membrane] (Canis familiaris)

ACSL3 [endoplasmic reticulum membrane] (Gallus gallus)

ACSL3 [endoplasmic reticulum membrane] (Saccharomyces cerevisiae)

ACSL3 [endoplasmic reticulum membrane] (Schizosaccharomyces pombe)

ACSL3 [endoplasmic reticulum membrane] (Sus scrofa)

Cross References

OpenTargets

ENSG00000123983

ENSEMBL

ENST00000679558, ENSP00000375918, ENST00000679514, ENST00000680921, ENST00000680147, ENST00000680251, ENST00000681383, ENSP00000504907, ENST00000680395, ENST00000680684, ENSP00000505856, ENST00000681697, ENSP00000506468, ENSP00000505400, ENSP00000505654, ENSP00000350012, ENSP00000505940, ENSP00000504861, ENSP00000506361, ENSP00000505793, ENST00000357430, ENST00000392066

IntEnz

6.2.1.15

HPA

ENSG00000123983-ACSL3

PRO

O95573

Pharos - Targets

O95573

GlyGen

O95573

HMDB Protein

HMDBP00647

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	21
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.527	2
UniProt:Q96RY7 IFT140	2	IFT140 [cilium] (R-HSA-5610382) IFT140 [ciliary tip] (R-HSA-5625345)	0.508	2
UniProt:Q8NEZ3 WDR19	2	WDR19 [ciliary tip] (R-HSA-5625347) WDR19 [cilium] (R-HSA-5610446)	0.508	2
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.483	3
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	2

Cite Us!