Reactome | GGC-RAB14 [cytoplasmic vesicle membrane]

GGC-RAB14 [cytoplasmic vesicle membrane]

Stable Identifier

R-HSA-1445086

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytoplasmic vesicle membrane

Synonyms

Ras-related protein Rab-14, RAB14_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P61106 RAB14

Gene Names

RAB14

Chain

initiator methionine:, chain:2-215

Reference Genes

BioGPS Gene:51552 RAB14

COSMIC (genes):RAB14 RAB14

CTD Gene:51552 RAB14

dbSNP Gene:51552 RAB14

ENSEMBL:ENSG00000119396 RAB14

ENSEMBL_homo_sapiens_GENE:ENSG00000119396.12 RAB14

HGNC:16524 RAB14

KEGG Gene (Homo sapiens):51552 RAB14

Monarch:51552 RAB14

NCBI Gene:51552 RAB14

OMIM:612673 RAB14

UCSC:P61106 RAB14

Reference Transcript

RefSeq:NM_016322.3 RAB14

Other Identifiers

11719448_at

11719449_at

11719450_at

11719451_at

17098004

200927_PM_s_at

200927_s_at

200928_PM_s_at

200928_s_at

211503_PM_s_at

211503_s_at

2684681

3223871

3223873

3223874

3223875

3223876

3223877

3223878

3223880

3223883

3223885

3223886

3223888

3223890

35325_at

46027_at

51552

8163882

A_23_P216984

A_24_P115511

A_24_P4272

GE56875

GE82105

GO:0000139

GO:0000166

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005576

GO:0005615

GO:0005764

GO:0005765

GO:0005768

GO:0005769

GO:0005770

GO:0005773

GO:0005783

GO:0005791

GO:0005794

GO:0005795

GO:0005802

GO:0005829

GO:0005886

GO:0006886

GO:0006895

GO:0007040

GO:0008092

GO:0008543

GO:0012505

GO:0015031

GO:0016020

GO:0016192

GO:0016787

GO:0019003

GO:0023052

GO:0030140

GO:0031410

GO:0031489

GO:0031901

GO:0032456

GO:0032880

GO:0042175

GO:0042742

GO:0043226

GO:0043231

GO:0045335

GO:0045995

GO:0046907

GO:0048471

GO:0048856

GO:0055037

GO:0055038

GO:0070062

GO:0070821

GO:0090382

GO:0090387

GO:0098542

HMNXSV003004091

Hs.5807.0.S2_3p_a_at

ILMN_1735765

PH_hs_0000587

TC09001543.hg

g6563199_3p_s_at

g7328165_3p_a_at

Participates

as a component of

as a member of

GGC-RAB8A,10,13,14 [cytoplasmic vesicle membrane] (Homo sapiens)

Other forms of this molecule

GGC-RAB14 [recycling endosome membrane]

GGC-RAB14 [cytosol]

RAB14 [cytosol]

RAB14 [early endosome membrane]

RAB14 [plasma membrane]

RAB14 [tertiary granule membrane]

Modified Residues

Name

S-geranylgeranyl-L-cysteine at 213

Coordinate

213

PsiMod Name

S-geranylgeranyl-L-cysteine [MOD:00113]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.

Name

S-geranylgeranyl-L-cysteine at 215

Coordinate

215

PsiMod Name

S-geranylgeranyl-L-cysteine [MOD:00113]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-geranylgeranyl-L-cysteine.

Cross References

RefSeq

NP_057406.2

OpenTargets

ENSG00000119396

GeneCards

P61106

HPA

ENSG00000119396-RAB14

Ensembl

ENST00000703999, ENSP00000515614, ENSG00000119396, ENST00000704000, ENSP00000515613, ENST00000373840, ENSP00000362946

PRO

P61106

Pharos - Targets

P61106

PDB

4DRZ, 1Z0F, 4D0G

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.718	6
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	12
UniProt:P0DTC3 3a	9	O-glycosyl 3a [virion membrane] (R-COV-9694395) O-glycosyl 3a [endocytic vesicle membrane] (R-COV-9694729) O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694386) GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694658) 3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694716) 3a [endoplasmic reticulum lumen] (R-COV-9694584) O-glycosyl 3a [endolysosome membrane] (R-COV-9754541) O-glycosyl 3a [plasma membrane] (R-COV-9694433) O-glycosyl 3a [extracellular region] (R-COV-9694387)	0.527	2