Reactome | MCM5 [nucleoplasm]

MCM5 [nucleoplasm]

Stable Identifier

R-HSA-68551

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Mcm5, DNA replication licensing factor MCM5, CDC46 homolog, P1-CDC46

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G2/M Checkpoints (Homo sapiens)
    - Activation of ATR in response to replication stress (Homo sapiens)
      - Activation of claspin (Homo sapiens)
        
        Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
      - Loading of claspin onto DNA during replication origin firing (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - Activation of the pre-replicative complex (Homo sapiens)
        
        CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        Cdt1 is displaced from the pre-replicative complex (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        DNA polymerase alpha:primase binds at the origin (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon binds at the origin (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
        
        MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        Mcm2-7 is phosphorylated by DDK (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        p-MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Synthesis of DNA (Homo sapiens)
      - DNA strand elongation (Homo sapiens)
        
        Unwinding of DNA (Homo sapiens)
        
        MCM2-7 mediated fork unwinding (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        Multiple proteins are localized at replication fork (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        Unwinding complex at replication fork [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
      - Switching of origins to a post-replicative state (Homo sapiens)
        
        Mcm4,6,7 trimer forms and associates with the replication fork (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        Orc1 removal from chromatin (Homo sapiens)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P33992 MCM5

Gene Names

MCM5, CDC46

Chain

initiator methionine:, chain:2-734

Reference Genes

BioGPS Gene:4174 MCM5

COSMIC (genes):MCM5 MCM5

CTD Gene:4174 MCM5

dbSNP Gene:4174 MCM5

ENSEMBL:ENSG00000100297 MCM5

ENSEMBL_homo_sapiens_GENE:ENSG00000100297.16 MCM5

HGNC:6948 MCM5

KEGG Gene (Homo sapiens):4174 MCM5

Monarch:4174 MCM5

NCBI Gene:4174 MCM5

OMIM:602696 MCM5

UCSC:P33992 MCM5

Reference Transcript

RefSeq:NM_006739.3 MCM5

Other Identifiers

11748675_a_at

16929573

201755_PM_at

201755_at

216237_PM_s_at

216237_s_at

3944148

3944149

3944151

3944153

3944154

3944155

3944157

3944159

3944160

3944162

3944163

3944164

3944165

3944167

3944168

3944169

3944170

3944171

3944172

3944174

3944175

3944180

3944181

3944182

3944183

4174

46492_at

8072687

982_at

A_33_P3284951

GO:0000166

GO:0000228

GO:0000727

GO:0000781

GO:0003677

GO:0003688

GO:0003697

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0006260

GO:0006268

GO:0006270

GO:0006281

GO:0006310

GO:0007049

GO:0016020

GO:0016787

GO:0016887

GO:0017116

GO:0030174

GO:0032508

GO:0032991

GO:0042555

GO:0043138

GO:0043226

GO:0051301

GO:0071162

GO:0140097

GO:0140657

HMNXSV003016392

HMNXSV003039658

Hs.77171.1.A1_3p_a_at

PH_hs_0004448

TC22000260.hg

TC22001090.hg

X74795_at

g6981191_3p_a_at

Participates

as an output of

Mcm4,6,7 trimer forms and associates with the replication fork (Homo sapiens)

as an input of

MCM3 binds MCM5 (Homo sapiens)

as a component of

MCM3:MCM5 [nucleoplasm] (Homo sapiens)

Inferred To

Mcm5 [nucleoplasm] (Rattus norvegicus)

MCM5 [nucleoplasm] (Bos taurus)

MCM5 [nucleoplasm] (Caenorhabditis elegans)

MCM5 [nucleoplasm] (Canis familiaris)

MCM5 [nucleoplasm] (Drosophila melanogaster)

MCM5 [nucleoplasm] (Gallus gallus)

MCM5 [nucleoplasm] (Mus musculus)

MCM5 [nucleoplasm] (Plasmodium falciparum)

MCM5 [nucleoplasm] (Saccharomyces cerevisiae)

MCM5 [nucleoplasm] (Schizosaccharomyces pombe)

MCM5 [nucleoplasm] (Sus scrofa)

MCM5 [nucleoplasm] (Xenopus tropicalis)

mcm5 [nucleoplasm] (Danio rerio)

mcm5 [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_006730.2

OpenTargets

ENSG00000100297

GeneCards

P33992

HPA

ENSG00000100297-MCM5

Ensembl

ENSP00000216122, ENST00000216122, ENSG00000100297

PRO

P33992

Pharos - Targets

P33992

HMDB Protein

HMDBP11819

PDB

6XTY, 8B9D, 7PFO, 7PLO, 7W1Y, 7W68, 6XTX

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BTE3 MCMBP			0.886	16
UniProt:P25205 MCM3	1	MCM3 [nucleoplasm] (R-HSA-68546)	0.845	8
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.8	5
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.688	10
UniProt:Q9UJ70 NAGK	1	NAGK [cytosol] (R-HSA-6803742)	0.527	2
UniProt:Q14691 GINS1	1	GINS1 [nucleoplasm] (R-HSA-176955)	0.527	2
UniProt:Q9BXJ5 C1QT2			0.527	2
UniProt:Q9NYP3 DONS			0.504	4
UniProt:Q9Y468 L3MBTL1	1	L3MBTL1 [nucleoplasm] (R-HSA-3222110)	0.499	2
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) HIST1H4 [nucleoplasm] (R-HSA-181902)	0.499	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	6
UniProt:Q12905 ILF2	5	ILF2 [cytosol] (R-HSA-9836392) ILF2 [tertiary granule lumen] (R-HSA-6800995) ILF2 [extracellular region] (R-HSA-6799684) ILF2 [ficolin-1-rich granule lumen] (R-HSA-6801001) ILF2 [specific granule lumen] (R-HSA-6799611)	0.462	4

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