Reactome | MCM5 [nucleoplasm]

MCM5 [nucleoplasm]

Stable Identifier

R-HSA-68551

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Mcm5, DNA replication licensing factor MCM5, CDC46 homolog, P1-CDC46

Locations in the PathwayBrowser

Expand all

Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - G2/M Checkpoints (Homo sapiens)
    - Activation of ATR in response to replication stress (Homo sapiens)
      - Activation of claspin (Homo sapiens)
        
        Cdc45:CDK:DDK:Mcm10:Activated claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
      - Loading of claspin onto DNA during replication origin firing (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        Cdc45:CDK:DDK:Mcm10:claspin:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - Mitotic G1 phase and G1/S transition (Homo sapiens)
    - G1/S Transition (Homo sapiens)
      - Activation of the pre-replicative complex (Homo sapiens)
        
        CDK and DDK associate with the Mcm10:pre-replicative complex (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        Cdc45 associates with the pre-replicative complex at the origin (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        Cdt1 is displaced from the pre-replicative complex (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        DNA polymerase alpha:primase binds at the origin (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        DNA polymerase epsilon binds at the origin (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45:RPA1-4 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex:CDC45 [nucleoplasm] (Homo sapiens)
        
        CDK:DDK:MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM10:active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        active pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 (Homo sapiens)
        
        MCM10:pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        Mcm2-7 is phosphorylated by DDK (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        p-MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
  - S Phase (Homo sapiens)
    - Synthesis of DNA (Homo sapiens)
      - DNA strand elongation (Homo sapiens)
        
        Unwinding of DNA (Homo sapiens)
        
        MCM2-7 mediated fork unwinding (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        Multiple proteins are localized at replication fork (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        Unwinding complex at replication fork [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
      - Switching of origins to a post-replicative state (Homo sapiens)
        
        Mcm4,6,7 trimer forms and associates with the replication fork (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        Orc1 removal from chromatin (Homo sapiens)
        
        Orc1 is phosphorylated by cyclin A/CDK2 (Homo sapiens)
        
        pre-replicative complex (Orc1-minus) [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)
        
        pre-replicative complex [nucleoplasm] (Homo sapiens)
        
        MCM2-7 [nucleoplasm] (Homo sapiens)
        
        MCM3:MCM5 [nucleoplasm] (Homo sapiens)
        
        MCM5 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P33992 MCM5

Gene Names

MCM5, CDC46

Chain

initiator methionine:1, chain:2-734

Reference Genes

BioGPS Gene:4174 MCM5

COSMIC (genes):MCM5 MCM5

CTD Gene:4174 MCM5

dbSNP Gene:4174 MCM5

ENSEMBL:ENSG00000100297 MCM5

HGNC:6948 MCM5

KEGG:hsa:4174 MCM5

Monarch:4174 MCM5

NCBI Gene:4174 MCM5

OMIM:602696 MCM5

UCSC:P33992 MCM5

Reference Transcript

RefSeq:NM_006739.3 MCM5

Other Identifiers

11748675_a_at

16929573

201755_PM_at

201755_at

216237_PM_s_at

216237_s_at

3944148

3944149

3944150

3944151

3944152

3944153

3944154

3944155

3944156

3944157

3944159

3944160

3944161

3944162

3944163

3944164

3944165

3944167

3944168

3944169

3944170

3944171

3944172

3944173

3944174

3944175

3944176

3944177

3944178

3944179

3944180

3944181

3944182

3944183

4174

46492_at

8072687

982_at

A_14_P108090

A_14_P138023

A_23_P132277

A_33_P3284951

GE62378

GO:0000166

GO:0000727

GO:0000781

GO:0003677

GO:0003688

GO:0003697

GO:0003824

GO:0004386

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0006260

GO:0006270

GO:0006281

GO:0006310

GO:0016020

GO:0016787

GO:0016887

GO:0017116

GO:0030174

GO:0042555

GO:0043138

GO:0051301

GO:0071162

GO:0140097

GO:0140657

HMNXSV003003827

HMNXSV003016392

HMNXSV003039658

Hs.77171.1.A1_3p_a_at

ILMN_1815169

PH_hs_0004448

TC22000260.hg

TC22001090.hg

X74795_at

g6981191_3p_a_at

p11194

Participates

as an output of

as an input of

MCM3 binds MCM5 (Homo sapiens)

as a component of

MCM3:MCM5 [nucleoplasm] (Homo sapiens)

Inferred To

Mcm5 [nucleoplasm] (Drosophila melanogaster)

Mcm5 [nucleoplasm] (Mus musculus)

Mcm5 [nucleoplasm] (Rattus norvegicus)

mcm-5 [nucleoplasm] (Caenorhabditis elegans)

MCM5 [nucleoplasm] (Bos taurus)

MCM5 [nucleoplasm] (Canis familiaris)

MCM5 [nucleoplasm] (Gallus gallus)

MCM5 [nucleoplasm] (Plasmodium falciparum)

MCM5 [nucleoplasm] (Saccharomyces cerevisiae)

MCM5 [nucleoplasm] (Sus scrofa)

mcm5 [nucleoplasm] (Danio rerio)

mcm5 [nucleoplasm] (Dictyostelium discoideum)

mcm5 [nucleoplasm] (Schizosaccharomyces pombe)

mcm5 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_006730.2

OpenTargets

ENSG00000100297

ENSEMBL

ENSP00000216122, ENST00000216122, ENSG00000100297

IntEnz

3.6.4.12

HPA

ENSG00000100297-MCM5

GeneCards

MCM5

PRO

P33992

Pharos - Targets

P33992

GlyGen

P33992

HMDB Protein

HMDBP11819

PDB

8B9D, 7PFO, 7PLO, 8S0E, 8S0D, 8W0F, 8W0I, 8W0G, 9CAQ, 8S0B, 6XTX, 6XTY, 8W0E, 8S0A, 7W1Y, 8S09, 8S0F, 7W68

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BTE3 MCMBP			0.886	16
UniProt:P25205 MCM3	1	MCM3 [nucleoplasm] (R-HSA-68546)	0.845	8
UniProt:P49736 MCM2	1	MCM2 [nucleoplasm] (R-HSA-68557)	0.8	5
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.759	12
UniProt:Q9BXJ5 C1QT2			0.527	2
UniProt:Q14691 GINS1	1	GINS1 [nucleoplasm] (R-HSA-176955)	0.527	2
UniProt:Q9UJ70 NAGK	1	NAGK [cytosol] (R-HSA-6803742)	0.527	2
UniProt:Q9NYP3 DONS			0.504	4
UniProt:P62805 H4C1	17	HIST1H4 [nucleoplasm] (R-HSA-181902) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) HIST1H4A [extracellular region] (R-HSA-977569) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531)	0.499	2
UniProt:Q9Y468 L3MBTL1	1	L3MBTL1 [nucleoplasm] (R-HSA-3222110)	0.499	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	6
UniProt:Q12905 ILF2	5	ILF2 [cytosol] (R-HSA-9836392) ILF2 [tertiary granule lumen] (R-HSA-6800995) ILF2 [extracellular region] (R-HSA-6799684) ILF2 [specific granule lumen] (R-HSA-6799611) ILF2 [ficolin-1-rich granule lumen] (R-HSA-6801001)	0.462	4

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