Reactome | MTOR [nucleoplasm]

MTOR [nucleoplasm]

Stable Identifier

R-HSA-5083674

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

mTOR

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External Reference Information

External Reference

UniProt:P42345 MTOR

Gene Names

MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1

Chain

chain:1-2549

Reference Genes

BioGPS Gene:2475 MTOR

COSMIC (genes):MTOR MTOR

CTD Gene:2475 MTOR

dbSNP Gene:2475 MTOR

ENSEMBL:ENSG00000198793 MTOR

HGNC:3942 MTOR

KEGG:hsa:2475 MTOR

Monarch:2475 MTOR

NCBI Gene:2475 MTOR

OMIM:601231 MTOR

UCSC:P42345 MTOR

Reference Transcript

Other Identifiers

11716133_a_at

11716134_a_at

11750567_a_at

16681661

202288_PM_at

202288_at

2396536

2396538

2396539

2396540

2396541

2396542

2396543

2396544

2396545

2396546

2396547

2396548

2396549

2396550

2396552

2396553

2396555

2396556

2396557

2396560

2396561

2396562

2396563

2396564

2396565

2396567

2396569

2396570

2396571

2396572

2396573

2396574

2396575

2396576

2396577

2396579

2396580

2396581

2396582

2396583

2396584

2396586

2396587

2396588

2396589

2396598

2396599

2396600

2396603

2396604

2396605

2396606

2396607

2396609

2396610

2396611

2396612

2396613

2396614

2396615

2396616

2396617

2396618

2396619

2396620

2396622

2396623

2396625

2396628

2396629

2396633

2396635

2396637

2475

267_at

40139_at

45997_at

7912412

84204_at

A_23_P34606

GE81461

GO:0000139

GO:0001002

GO:0001003

GO:0001006

GO:0001156

GO:0001558

GO:0001932

GO:0002296

GO:0002376

GO:0003007

GO:0003012

GO:0003179

GO:0003677

GO:0003824

GO:0004672

GO:0004674

GO:0005515

GO:0005524

GO:0005634

GO:0005635

GO:0005654

GO:0005737

GO:0005739

GO:0005741

GO:0005764

GO:0005765

GO:0005773

GO:0005783

GO:0005789

GO:0005794

GO:0005829

GO:0006091

GO:0006112

GO:0006207

GO:0006355

GO:0006468

GO:0006914

GO:0006954

GO:0006974

GO:0007010

GO:0007040

GO:0007281

GO:0007584

GO:0008361

GO:0009267

GO:0009408

GO:0009791

GO:0010506

GO:0010507

GO:0010592

GO:0010628

GO:0010718

GO:0010831

GO:0012501

GO:0012505

GO:0016020

GO:0016236

GO:0016241

GO:0016242

GO:0016301

GO:0016310

GO:0016605

GO:0016740

GO:0018105

GO:0019228

GO:0022414

GO:0030030

GO:0030154

GO:0030163

GO:0030307

GO:0030425

GO:0030838

GO:0031295

GO:0031410

GO:0031529

GO:0031641

GO:0031648

GO:0031667

GO:0031669

GO:0031670

GO:0031929

GO:0031931

GO:0031932

GO:0032516

GO:0032868

GO:0032869

GO:0032956

GO:0033173

GO:0034198

GO:0035264

GO:0038202

GO:0042752

GO:0042802

GO:0043022

GO:0043066

GO:0043200

GO:0043226

GO:0043276

GO:0044877

GO:0045335

GO:0045670

GO:0045727

GO:0045792

GO:0045821

GO:0045945

GO:0045948

GO:0046777

GO:0046889

GO:0048266

GO:0048511

GO:0048709

GO:0048714

GO:0048738

GO:0048856

GO:0050731

GO:0050877

GO:0050882

GO:0051128

GO:0051219

GO:0051247

GO:0051496

GO:0051549

GO:0051647

GO:0051896

GO:0051897

GO:0055006

GO:0055013

GO:0055086

GO:0060048

GO:0061431

GO:0070885

GO:0071230

GO:0071233

GO:0071456

GO:0071470

GO:0080135

GO:0090559

GO:0106310

GO:0140096

GO:1900034

GO:1900181

GO:1901796

GO:1901838

GO:1903691

GO:1904059

GO:1904690

GO:1905672

GO:1905857

GO:1990253

GO:2000785

HMNXSV003015930

HMNXSV003049665

ILMN_1769031

L34075_at

PH_hs_0016579

TC01002197.hg

g3282238_3p_at

Participates

as a component of

MLST8:MTOR:RPTOR:AKT1S1 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

MTOR [cytosol]

Inferred To

MTOR [nucleoplasm] (Bos taurus)

MTOR [nucleoplasm] (Canis familiaris)

MTOR [nucleoplasm] (Gallus gallus)

MTOR [nucleoplasm] (Mus musculus)

MTOR [nucleoplasm] (Rattus norvegicus)

MTOR [nucleoplasm] (Sus scrofa)

let-363 [nucleoplasm] (Caenorhabditis elegans)

tor [nucleoplasm] (Dictyostelium discoideum)

mTor [nucleoplasm] (Drosophila melanogaster)

tor2 [nucleoplasm] (Schizosaccharomyces pombe)

TOR2 [nucleoplasm] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_004949.1, XP_005263495.1

ZINC - World Drugs

MTOR_HUMAN

Guide to Pharmacology - Targets

2109

OpenTargets

ENSG00000198793

ENSEMBL

ENSP00000354558, ENST00000361445

ZINC - FDA approved

MTOR_HUMAN

ZINC - Substances

MTOR_HUMAN

ZINC target

P42345

PRO

P42345

GlyGen

P42345

PDB

7PEC, 7PE9, 1NSG, 4JT5, 7PE8, 4DRI, 4JT6, 5WBY, 8ER6, 4DRJ, 3JBZ, 4JSX, 4FAP, 7OWG, 3FAP, 2GAQ, 7UXC, 4JSN, 7TZO, 5WBH, 2NPU, 6ZWM, 6ZWO, 5H64, 6M4U, 1FAP, 6SB0, 6SB2, 4DRH, 7PEA, 7PEB, 7UXH, 4JSV, 4JSP, 6BCX, 8ERA, 7PE7, 5ZCS, 7EPD, 5FLC, 1AUE, 8ER7, 5WBU, 6BCU, 2FAP, 6M4W, 8PPZ, 2RSE, 5GPG

ZINC - Investigational

MTOR_HUMAN

HPA

ENSG00000198793-MTOR

Pharos - Targets

P42345

Orphanet

MTOR

ZINC - Predictions - Purchasable

MTOR_HUMAN

HMDB Protein

HMDBP02611

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62942 FKBP1A	1	FKBP1A [cytosol] (R-HSA-2026007)	0.786	5
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.731	4
UniProt:O75385 ULK1	7	ULK1 [cytosol] (R-HSA-1632847) ULK1 [mitochondrial outer membrane] (R-HSA-8948145) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) p-S758-ULK1 [cytosol] (R-HSA-5672131) ULK1 [recycling endosome] (R-HSA-8854761)	0.702	7
UniProt:Q96B36 AKT1S1	4	AKT1S1 [cytosol] (R-HSA-200155) p-S183,T246-AKT1S1 [cytosol] (R-HSA-200163) p-T246-AKT1S1 [cytosol] (R-HSA-377124) AKT1S1 [nucleoplasm] (R-HSA-5083637)	0.669	3
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.65	3
UniProt:Q12933 TRAF2	5	TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199)	0.536	2
UniProt:Q9NZQ7 CD274	1	CD274 [plasma membrane] (R-HSA-3211776)	0.527	2
UniProt:O75695 RP2	1	RP2 [cilium] (R-HSA-5624052)	0.527	2
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.525	2
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.483	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	4
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.483	3