Reactome | EIF3L [cytosol]

EIF3L [cytosol]

Stable Identifier

R-HSA-377452

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

eIF3l

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9Y262 EIF3L

Gene Names

EIF3L, EIF3EIP, EIF3S6IP, HSPC021, HSPC025, MSTP005

Chain

initiator methionine:, chain:2-564

Reference Genes

BioGPS Gene:51386 EIF3L

COSMIC (genes):EIF3L EIF3L

CTD Gene:51386 EIF3L

dbSNP Gene:51386 EIF3L

ENSEMBL:ENSG00000100129 EIF3L

ENSEMBL_homo_sapiens_GENE:ENSG00000100129.18 EIF3L

HGNC:18138 EIF3L

KEGG Gene (Homo sapiens):51386 EIF3L

Monarch:51386 EIF3L

NCBI Gene:51386 EIF3L

OMIM:619197 EIF3L

UCSC:Q9Y262 EIF3L

Reference Transcript

Other Identifiers

11718273_a_at

11718274_s_at

11718275_x_at

11753373_a_at

16929943

217719_PM_at

217719_at

3243631

3243634

3243635

3285646

3285649

3285651

3546453

3546454

3546457

3546463

3945058

3945060

3945061

3945062

3945064

3945065

3945066

3945067

3945068

3945069

3945071

3945072

3945073

3945078

3945080

3945081

46223_at

51386

8072946

A_14_P104527

GE58677

GO:0001650

GO:0001732

GO:0002181

GO:0002183

GO:0003723

GO:0003743

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0005852

GO:0006412

GO:0006413

GO:0016020

GO:0016282

GO:0032991

GO:0033290

GO:0043226

GO:0045182

GO:0045202

GO:0065003

GO:0075525

HMNXSV003057588

Hs.287757.0.S1_3p_s_at

ILMN_1762725

g7705432_3p_at

Participates

as a component of

eIF3 subunits complex [cytosol] (Homo sapiens)

Inferred To

Ghost homologue of EIF3L [cytosol] (Saccharomyces cerevisiae)

Ghost homologue of EIF3L [cytosol] (Schizosaccharomyces pombe)

eif3L [cytosol] (Dictyostelium discoideum)

eif-3.L [cytosol] (Caenorhabditis elegans)

eIF3l [cytosol] (Drosophila melanogaster)

eif3l [cytosol] (Danio rerio)

eif3l [cytosol] (Xenopus tropicalis)

EIF3L [cytosol] (Bos taurus)

EIF3L [cytosol] (Canis familiaris)

EIF3L [cytosol] (Gallus gallus)

EIF3L [cytosol] (Plasmodium falciparum)

EIF3L [cytosol] (Sus scrofa)

Eif3l [cytosol] (Mus musculus)

Eif3l [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001229852.1, NP_057175.1

OpenTargets

ENSG00000100129

HPA

ENSG00000100129-EIF3L

GeneCards

Q9Y262

Ensembl

ENST00000624234, ENSG00000100129, ENSP00000485663, ENSP00000499067, ENST00000652021, ENSP00000371099, ENST00000381683

PRO

Q9Y262

Pharos - Targets

Q9Y262

PDB

6ZP4, 6ZVJ, 6YBD, 6ZMW, 3J8C, 3J8B, 6ZON, 7QP6, 6FEC, 7QP7, 7A09

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	5
UniProt:Q7Z4L5 TTC21B	2	TTC21B [ciliary tip] (R-HSA-5625349) TTC21B [cilium] (R-HSA-5610430)	0.508	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	9