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EIF3L [cytosol]
Stable Identifier
R-HSA-377452
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF3l
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3L [cytosol] (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3L [cytosol] (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3L [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3L [cytosol] (Homo sapiens)
Formation of a pool of free 40S subunits (Homo sapiens)
eIF3 and eIF1A bind to the 40S subunit (Homo sapiens)
40S:eIF3:eIF1A [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3L [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3L [cytosol] (Homo sapiens)
Formation of the ternary complex, and subsequently, the 43S complex (Homo sapiens)
Formation of the 43S pre-initiation complex (Homo sapiens)
40S:eIF3:eIF1A [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3L [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3L [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3L [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3L [cytosol] (Homo sapiens)
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3L [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3L [cytosol] (Homo sapiens)
Start codon recognition (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3L [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3L [cytosol] (Homo sapiens)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
43S complex [cytosol] (Homo sapiens)
eIF3 subunits complex [cytosol] (Homo sapiens)
EIF3L [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y262 EIF3L
Gene Names
EIF3L, EIF3EIP, EIF3S6IP, HSPC021, HSPC025, MSTP005
Chain
initiator methionine:1, chain:2-564
Reference Genes
BioGPS Gene:51386 EIF3L
COSMIC (genes):EIF3L EIF3L
CTD Gene:51386 EIF3L
dbSNP Gene:51386 EIF3L
ENSEMBL:ENSG00000100129 EIF3L
ENSEMBL:ENSG00000100129.18 EIF3L
HGNC:18138 EIF3L
KEGG Gene (Homo sapiens):51386 EIF3L
Monarch:51386 EIF3L
NCBI Gene:51386 EIF3L
OMIM:619197 EIF3L
UCSC:Q9Y262 EIF3L
Reference Transcript
RefSeq:NM_001242923.1 EIF3L
RefSeq:NM_016091.3 EIF3L
Other Identifiers
11718273_a_at
11718274_s_at
11718275_x_at
11753373_a_at
16929943
217719_PM_at
217719_at
3243631
3243634
3243635
3285646
3285649
3285651
3546453
3546454
3546457
3546463
3945058
3945060
3945061
3945062
3945064
3945065
3945066
3945067
3945068
3945069
3945071
3945072
3945073
3945078
3945080
3945081
46223_at
51386
8072946
A_14_P104527
GE58677
GO:0001650
GO:0001732
GO:0002181
GO:0002183
GO:0003723
GO:0003743
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0005852
GO:0006412
GO:0006413
GO:0016020
GO:0016282
GO:0032991
GO:0033290
GO:0043226
GO:0045182
GO:0045202
GO:0065003
GO:0075525
HMNXSV003057588
Hs.287757.0.S1_3p_s_at
ILMN_1762725
g7705432_3p_at
Participates
as a component of
eIF3 subunits complex [cytosol] (Homo sapiens)
Inferred To
Ghost homologue of EIF3L [cytosol]
(Saccharomyces cerevisiae)
Ghost homologue of EIF3L [cytosol]
(Schizosaccharomyces pombe)
eif3L [cytosol]
(Dictyostelium discoideum)
eif-3.L [cytosol]
(Caenorhabditis elegans)
eIF3l [cytosol]
(Drosophila melanogaster)
eif3l [cytosol]
(Danio rerio)
eif3l [cytosol]
(Xenopus tropicalis)
EIF3L [cytosol]
(Bos taurus)
EIF3L [cytosol]
(Canis familiaris)
EIF3L [cytosol]
(Gallus gallus)
EIF3L [cytosol]
(Plasmodium falciparum)
EIF3L [cytosol]
(Sus scrofa)
Eif3l [cytosol]
(Mus musculus)
Eif3l [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001229852.1
,
NP_057175.1
OpenTargets
ENSG00000100129
GeneCards
Q9Y262
HPA
ENSG00000100129-EIF3L
Ensembl
ENSP00000485663
,
ENST00000652021
,
ENST00000381683
,
ENST00000624234
,
ENSG00000100129
,
ENSP00000499067
,
ENSP00000371099
PRO
Q9Y262
Pharos - Targets
Q9Y262
PDB
7QP6
,
3J8B
,
6FEC
,
7A09
,
6YBD
,
7QP7
,
6ZMW
,
6ZVJ
,
3J8C
,
6ZON
,
6ZP4
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7Z4L5 TTC21B
2
TTC21B [ciliary tip]
(R-HSA-5625349)
TTC21B [cilium]
(R-HSA-5610430)
0.508
2
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