Reactome | SEC61A2 [endoplasmic reticulum membrane]

SEC61A2 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-444585

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Protein transport protein Sec61 subunit alpha isoform 2, S61A2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9H9S3 SEC61A2

Gene Names

SEC61A2

Chain

chain:1-476

Reference Genes

BioGPS Gene:55176 SEC61A2

COSMIC (genes):SEC61A2 SEC61A2

CTD Gene:55176 SEC61A2

dbSNP Gene:55176 SEC61A2

ENSEMBL:ENSG00000065665 SEC61A2

HGNC:17702 SEC61A2

KEGG:hsa:55176 SEC61A2

Monarch:55176 SEC61A2

NCBI Gene:55176 SEC61A2

OMIM:618271 SEC61A2

UCSC:Q9H9S3 SEC61A2

Reference Transcript

Other Identifiers

11742097_a_at

11742098_a_at

11744196_a_at

16702479

219499_PM_at

219499_at

228747_PM_at

228747_at

230215_PM_at

230215_at

3235415

3235416

3235417

3235418

3235419

3235420

3235422

3235423

3235425

3235426

3235429

3235430

3235431

3235432

3235434

3235435

3235437

3235438

3235439

3235440

3235441

3235442

3235443

3235444

3235445

3235446

3235447

3235449

49172_at

55176

73535_at

74690_at

78163_at

7926189

A_14_P109288

A_14_P125886

A_23_P161197

A_23_P399921

A_24_P415280

A_33_P3336287

GE55792

GE84811

GO:0003674

GO:0005048

GO:0005215

GO:0005515

GO:0005783

GO:0005784

GO:0005789

GO:0006616

GO:0006886

GO:0008150

GO:0008320

GO:0015031

GO:0016020

GO:0031204

GO:0043022

GO:0043226

GO:0055085

HMNXSV003036394

HMNXSV003055340

Hs.131840.1.S1_3p_at

Hs.301957.2.S1_3p_at

ILMN_1779381

PH_hs_0024071

PH_hs_0034879

TC10000090.hg

TC10001906.hg

g8922529_3p_at

Participates

as a candidate of

SEC61 alpha [endoplasmic reticulum membrane] (Homo sapiens)

Other forms of this molecule

SEC61A2 [phagocytic vesicle membrane]

Cross References

ENSEMBL

ENSP00000302048, ENST00000379033, ENSP00000368319, ENST00000298428, ENST00000304267, ENSP00000298428

OpenTargets

ENSG00000065665

HPA

ENSG00000065665-SEC61A2

PRO

Q9H9S3

Pharos - Targets

Q9H9S3

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60468 SEC61B	3	SEC61B [cytosol] (R-HSA-5250571) SEC61B [endoplasmic reticulum membrane] (R-HSA-264899) SEC61B [phagocytic vesicle membrane] (R-HSA-1236882)	0.564	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.527	4
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.527	3

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