Reactome | KARS [cytosol]

KARS [cytosol]

Stable Identifier

R-HSA-379568

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Lysyl-tRNA synthetase

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- MITF-M-regulated melanocyte development (Homo sapiens)
  - Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
    - MAPK-dependent phosphorylation of KARS (Homo sapiens)
      - aminoacyl-tRNA synthetase multienzyme complex [cytosol] (Homo sapiens)
        
        KARS homodimer [cytosol] (Homo sapiens)
        
        KARS [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q15046 KARS1

Gene Names

KARS1, KARS, KIAA0070

Chain

initiator methionine:, chain:2-597

Reference Genes

BioGPS Gene:3735 KARS1

CTD Gene:3735 KARS1

dbSNP Gene:3735 KARS1

ENSEMBL:ENSG00000065427 KARS

ENSEMBL_homo_sapiens_GENE:ENSG00000065427.15 KARS1

HGNC:6215 KARS1

KEGG Gene (Homo sapiens):3735 KARS1

Monarch:3735 KARS1

NCBI Gene:3735 KARS1

OMIM:601421 KARS1

UCSC:Q15046 KARS1

Reference Transcript

Other Identifiers

11733807_a_at

16828514

18671106

18671107

18671108

18671109

18671110

18671111

18671112

18671113

18671114

18671115

18671116

18671117

18671118

18671119

18671120

18671121

18671122

200079_PM_s_at

200079_s_at

200840_PM_at

200840_at

34336_at

3699758

3699759

3699760

3699762

3699764

3699765

3699766

3699767

3699768

3699769

3699771

3699773

3699774

3699776

3699779

3699780

3699781

3699782

3699786

3699787

3699790

3735

7892618

7892953

7893113

7893248

7893362

7893477

7893549

7893933

7894238

7894331

7894737

7895038

7895221

7895264

7895419

7895578

7895770

7895817

7896201

7896362

8002919

A_23_P152487

D31890_at

GE57175

GO:0000049

GO:0000166

GO:0002276

GO:0002376

GO:0002863

GO:0003676

GO:0003723

GO:0003824

GO:0003877

GO:0004812

GO:0004824

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005739

GO:0005759

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006399

GO:0006412

GO:0006418

GO:0006430

GO:0006520

GO:0006954

GO:0008033

GO:0010165

GO:0015966

GO:0016020

GO:0016597

GO:0016740

GO:0016874

GO:0017101

GO:0023052

GO:0042802

GO:0042803

GO:0043032

GO:0043226

GO:0045893

GO:0055086

GO:0070371

GO:0140098

HMNXSV003010174

ILMN_1777584

PH_hs_0000387

TC16001284.hg

TC16001967.hg

g11095908_3p_a_at

Participates

as a component of

KARS homodimer [cytosol] (Homo sapiens)

Other forms of this molecule

KARS [mitochondrial matrix]

p-S207 KARS [cytosol]

Inferred To

KARS [cytosol] (Gallus gallus)

KARS [cytosol] (Mus musculus)

KARS [cytosol] (Rattus norvegicus)

KARS1 [cytosol] (Bos taurus)

KARS1 [cytosol] (Canis familiaris)

KARS1 [cytosol] (Sus scrofa)

lysS [cytosol] (Dictyostelium discoideum)

LysRS [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_005539.1, NP_001123561.1

OpenTargets

ENSG00000065427

ZINC - Substances

SYK_HUMAN

ZINC - Biogenic

SYK_HUMAN

ZINC target

Q15046

PRO

Q15046

PDB

4DPG, 6ILH, 4YCW, 6ILD, 3BJU, 6CHD, 7EA9, 4YCU

GeneCards

Q15046

HPA

ENSG00000065427-KARS1

Ensembl

ENSP00000325448, ENST00000319410, ENSP00000303043, ENSG00000065427, ENST00000302445

Pharos - Targets

Q15046

Orphanet

20149

ZINC - Predictions - Purchasable

SYK_HUMAN

HMDB Protein

HMDBP00613

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00441 SOD1	5	SOD1 [extracellular region] (R-HSA-350705) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) SOD1 [cytosol] (R-HSA-350697) 2xHC-SOD1 [cytosol] (R-HSA-3299726)	0.556	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	4