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SPTAN1(1-1185) [cytosol]
Stable Identifier
R-HSA-202944
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
spectrin alpha chain/alpha-II-Fodrin fragment (1-1185)
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Apoptotic cleavage of cellular proteins (Homo sapiens)
Caspase-mediated cleavage of cytoskeletal proteins (Homo sapiens)
Caspase mediated cleavage of alpha-II-Fodrin (Homo sapiens)
SPTAN1(1-1185) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13813 SPTAN1
Gene Names
SPTAN1, NEAS, SPTA2
Chain
chain:1-2472
Reference Genes
BioGPS Gene:6709 SPTAN1
COSMIC (genes):SPTAN1 SPTAN1
CTD Gene:6709 SPTAN1
dbSNP Gene:6709 SPTAN1
ENSEMBL:ENSG00000197694 SPTAN1
HGNC:11273 SPTAN1
KEGG:hsa:6709 SPTAN1
Monarch:6709 SPTAN1
NCBI Gene:6709 SPTAN1
OMIM:182810 SPTAN1
UCSC:Q13813 SPTAN1
Reference Transcript
RefSeq:NM_003127.3 SPTAN1
RefSeq:NM_001195532.1 SPTAN1
RefSeq:NM_001130438.2 SPTAN1
Other Identifiers
11715963_a_at
11715964_x_at
11751947_a_at
11758363_s_at
11760403_at
17089735
208611_PM_s_at
208611_s_at
214925_PM_s_at
214925_s_at
215235_PM_at
215235_at
241150_PM_at
241150_at
3190559
3190560
3190562
3190563
3190564
3190565
3190566
3190567
3190568
3190569
3190570
3190571
3190572
3190573
3190574
3190576
3190577
3190578
3190579
3190580
3190581
3190582
3190583
3190584
3190585
3190586
3190588
3190589
3190592
3190593
3190594
3190595
3190596
3190597
3190598
3190599
3190600
3190601
3190602
3190603
3190604
3190605
3190606
3190607
3190608
3190609
3190610
3190611
3190612
3190613
3190614
3190615
3190616
3190618
3190619
3190620
3190621
3190622
3190623
3190624
3190625
3190626
3190627
3190628
3190629
3190630
3190631
3190632
3190633
3190634
3190635
3190636
3190637
3190638
3190639
3190640
3190641
3190642
3190643
3190644
3190645
3190646
33833_at
64221_at
6709
8158317
89935_at
A_14_P112681
A_14_P128750
A_14_P136143
A_23_P20832
A_33_P3373560
GE81239
GE84723
GE84880
GO:0003779
GO:0005198
GO:0005200
GO:0005509
GO:0005515
GO:0005516
GO:0005576
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005938
GO:0007010
GO:0008091
GO:0008092
GO:0015630
GO:0016020
GO:0030036
GO:0030054
GO:0030864
GO:0035580
GO:0042995
GO:0043226
GO:0043231
GO:0043232
GO:0045296
GO:0046872
GO:0051015
GO:0051693
GO:0070062
GO:1903561
GO:1904724
HMNXSV003023914
Hs.321666.0.S1_3p_s_at
Hs.77196.2.A1_3p_a_at
J05243_at
PH_hs_0024438
TC09000695.hg
Participates
as an output of
Caspase mediated cleavage of alpha-II-Fodrin (Homo sapiens)
Other forms of this molecule
SPTAN1 [cytosol]
SPTAN1(1186-2472) [cytosol]
SPTAN1 [specific granule lumen]
SPTAN1 [extracellular region]
SPTAN1 [tertiary granule lumen]
Inferred To
spc-1 [cytosol]
(Caenorhabditis elegans)
SPTAN1(1-1185) [cytosol]
(Dictyostelium discoideum)
SPTAN1(1-1185) [cytosol]
(Drosophila melanogaster)
SPTAN1(1-1185) [cytosol]
(Gallus gallus)
SPTAN1(1-1185) [cytosol]
(Mus musculus)
SPTAN1(1-1185) [cytosol]
(Rattus norvegicus)
Homologues of SPTAN1(1-1185) [cytosol]
(Dictyostelium discoideum)
sptan1 [cytosol]
(Danio rerio)
sptan1 [cytosol]
(Xenopus tropicalis)
ain1 [cytosol]
(Schizosaccharomyces pombe)
abpD [cytosol]
(Dictyostelium discoideum)
SPTAN1 [cytosol]
(Bos taurus)
SPTAN1 [cytosol]
(Canis familiaris)
SPTAN1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_003118.2
,
NP_001123910.1
,
NP_001182461.1
OpenTargets
ENSG00000197694
ENSEMBL
ENSP00000350882
,
ENST00000706487
,
ENST00000372739
,
ENST00000358161
,
ENSP00000516412
,
ENSP00000361824
,
ENSP00000361816
,
ENST00000372731
HPA
ENSG00000197694-SPTAN1
PRO
Q13813
Pharos - Targets
Q13813
Orphanet
SPTAN1
GlyGen
Q13813
HMDB Protein
HMDBP08004
PDB
3F31
,
5FWB
,
5FWC
,
2FOT
,
6ZEH
,
5FW9
,
3FB2
Interactors (16)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NRI5 DISC1
0.667
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
21
UniProt:Q01082 SPTBN1
3
SPTBN1(2-159)-FLT3(570-993) fusion [cytosol]
(R-HSA-9703316)
SPTBN1(2-159)-p-6Y-FLT3(570-993) fusion [cytosol]
(R-HSA-9703317)
SPTBN1 [cytosol]
(R-HSA-420048)
0.609
8
UniProt:P40692 MLH1
3
MLH1 [nucleoplasm]
(R-HSA-912495)
MLH1 H329P [nucleoplasm]
(R-HSA-5444512)
MLH1 S252* [nucleoplasm]
(R-HSA-5444526)
0.602
6
UniProt:Q9UI08 EVL
1
EVL [cytosol]
(R-HSA-426403)
0.593
4
UniProt:Q00597 FANCC
2
FANCC [cytosol]
(R-HSA-420801)
FANCC [nucleoplasm]
(R-HSA-419530)
0.589
2
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.569
10
UniProt:Q05682 CALD1
2
CALD1 [cytosol]
(R-HSA-264431)
p-S759, S789 CALD1 [cytosol]
(R-HSA-9754072)
0.564
2
UniProt:Q9NV70 EXOC1
2
EXOC1 [plasma membrane]
(R-HSA-2872284)
EXOC1 [cytosol]
(R-HSA-5623375)
0.553
2
UniProt:Q96MT8 CEP63
1
CEP63 [cytosol]
(R-HSA-380267)
0.547
2
UniProt:P42224 STAT1
8
STAT1 [cytosol]
(R-HSA-629622)
p-Y701-STAT1 [cytosol]
(R-HSA-3132766)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-6788624)
p-Y701-STAT1 [cytosol]
(R-HSA-8951202)
p-Y701-STAT1 [nucleoplasm]
(R-HSA-8985905)
p-Y701,S727-STAT1 [cytosol]
(R-HSA-9850842)
p-STAT1 [cytosol]
(R-HSA-8950418)
p-STAT1 [nucleoplasm]
(R-HSA-8987140)
0.547
2
UniProt:Q15691 MAPRE1
1
MAPRE1 [cytosol]
(R-HSA-376240)
0.527
2
UniProt:O15287 FANCG
2
FANCG [nucleoplasm]
(R-HSA-419532)
FANCG [cytosol]
(R-HSA-420788)
0.508
4
ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE
0.462
2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE
0.462
2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE
0.462
2
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