Reactome | PABPC1 [cytosol]

PABPC1 [cytosol]

Stable Identifier

R-HSA-156803

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PABP

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External Reference Information

External Reference

UniProt:P11940 PABPC1

Gene Names

PABPC1, PAB1, PABP, PABP1, PABPC2

Chain

chain:1-636

Reference Genes

BioGPS Gene:26986 PABPC1

COSMIC (genes):PABPC1 PABPC1

CTD Gene:26986 PABPC1

dbSNP Gene:26986 PABPC1

ENSEMBL:ENSG00000070756 PABPC1

HGNC:8554 PABPC1

KEGG:hsa:26986 PABPC1

Monarch:26986 PABPC1

NCBI Gene:26986 PABPC1

OMIM:604679 PABPC1

UCSC:P11940 PABPC1

Reference Transcript

Other Identifiers

11748097_x_at

11752278_x_at

11754246_x_at

17079672

215157_3p_x_at

215157_PM_x_at

215157_x_at

236907_PM_at

236907_at

26986

2701791

2766680

3146782

3146787

3146788

3146789

3146790

3146791

3146792

3146793

3146794

3146795

3146796

3146797

3146798

3146799

3146800

3146801

3146802

3146803

3146805

3146806

3146807

3146808

3146809

3146810

3146811

3146812

3146813

3146814

3146815

3146816

3146817

3146818

3146819

3146820

3146821

3146822

3146823

3146824

3146825

3146826

3146827

31950_at

31951_s_at

3419625

3419626

3482124

44806_at

59809_f_at

64962_r_at

8152079

82682_at

A_23_P82693

GE60230

GE643089

GO:0000184

GO:0000398

GO:0003676

GO:0003723

GO:0003729

GO:0003730

GO:0005515

GO:0005634

GO:0005681

GO:0005737

GO:0005829

GO:0005925

GO:0006397

GO:0008143

GO:0008266

GO:0008380

GO:0008494

GO:0010494

GO:0016020

GO:0016071

GO:0030027

GO:0031047

GO:0031252

GO:0036464

GO:0042995

GO:0043226

GO:0045070

GO:0045182

GO:0048255

GO:0060213

GO:0070062

GO:0070934

GO:0071013

GO:0106002

GO:1900152

GO:1900153

GO:1990904

GO:2000623

GO:2000767

HMNXSV003038156

Hs.144923.0.A1_3p_at

Hs.172182.2.A1_3p_s_at

Hs2.351295.1.S1_3p_at

ILMN_1761155

ILMN_2136133

PH_hs_0028309

TC08001481.hg

U68105_s_at

Z48501_s_at

Participates

as a component of

as an input of

as an output of

Inferred To

pabpc1a [cytosol] (Danio rerio)

pab-1 [cytosol] (Caenorhabditis elegans)

pabpc1 [cytosol] (Xenopus tropicalis)

pabpc1B [cytosol] (Dictyostelium discoideum)

Ghost homologue of PABPC1 [cytosol] (Drosophila melanogaster)

Ghost homologue of PABPC1 [cytosol] (Schizosaccharomyces pombe)

PES4 [cytosol] (Saccharomyces cerevisiae)

PABPC1 [cytosol] (Bos taurus)

PABPC1 [cytosol] (Canis familiaris)

PABPC1 [cytosol] (Gallus gallus)

PABPC1 [cytosol] (Plasmodium falciparum)

PABPC1 [cytosol] (Sus scrofa)

Pabpc1 [cytosol] (Mus musculus)

Pabpc1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_002559.2, XP_005250918.1

OpenTargets

ENSG00000070756

ENSEMBL

ENST00000523555, ENST00000318607, ENSP00000429892, ENSP00000430012, ENST00000522720, ENSP00000429119, ENSP00000428840, ENSP00000428749, ENST00000520142, ENST00000520804, ENSP00000313007, ENST00000521865, ENSP00000429790, ENST00000522658

HPA

ENSG00000070756-PABPC1

PRO

P11940

Pharos - Targets

P11940

GlyGen

P11940

PDB

3KTR, 1G9L, 2K8G, 3KTP, 3PTH, 2RQH, 2RQG, 5LGS, 2X04, 5LGR, 5DX8, 3KUR, 3KUS, 5DXA, 4F25, 4F02, 3KUJ, 3KUI, 7BN3, 5DX1, 8SMO, 3KUT, 4F26, 1CVJ, 1JH4, 5LGQ, 5LGP, 3PKN, 1JGN

Interactors (50)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H074 PAIP1	1	PAIP1 [cytosol] (R-HSA-429861)	0.969	22
UniProt:Q9HCJ0 TNRC6C	1	TNRC6C [cytosol] (R-HSA-427776)	0.909	15
UniProt:Q8IYD1 GSPT2	1	GSPT2 [cytosol] (R-HSA-143379)	0.891	10
UniProt:Q9BPZ3 PAIP2			0.86	15
UniProt:Q04637 EIF4G1	2	p-S1108,S1148,S1192-EIF4G1 [cytosol] (R-HSA-165762) EIF4G1 [cytosol] (R-HSA-72584)	0.835	6
UniProt:Q99700 ATX2			0.822	8
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.798	5
UniProt:O00571 DDX3X	3	DDX3X [secretory granule lumen] (R-HSA-6801275) DDX3X [extracellular region] (R-HSA-6806507) DDX3X [ficolin-1-rich granule lumen] (R-HSA-6801273)	0.789	10
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.763	5
UniProt:Q58A45 PAN3	1	PAN3 [cytosol] (R-HSA-429938)	0.704	4
UniProt:P15130 NCAP			0.697	4
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.674	3
UniProt:Q9HCJ0-1 TNRC6C			0.667	7
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.662	9
UniProt:Q9UPQ9 TNRC6B	1	TNRC6B [cytosol] (R-HSA-427777)	0.656	3
UniProt:Q14106 TOB2			0.656	5
UniProt:Q92900 UPF1	2	p-4S-UPF1 [cytosol] (R-HSA-927856) UPF1 [cytosol] (R-HSA-927734)	0.643	4
UniProt:Q9UKV8 AGO2	2	AGO2 [cytosol] (R-HSA-209723) AGO2 [nucleoplasm] (R-HSA-5578701)	0.643	6
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.643	4
UniProt:Q92615 LAR4B			0.59	4
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.569	11
UniProt:P15170 GSPT1	1	GSPT1 [cytosol] (R-HSA-8865759)	0.564	2
UniProt:Q8NDV7 TNRC6A	2	TNRC6A [nucleoplasm] (R-HSA-5578976) TNRC6A [cytosol] (R-HSA-427769)	0.564	3
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.558	5
UniProt:P50616 TOB1			0.558	4
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q99700-5 Q997005			0.556	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.548	12
UniProt:O43432 EIF4G3	1	EIF4G3 [cytosol] (R-HSA-1678827)	0.544	2
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.527	2
UniProt:Q9UL18 AGO1	2	EIF2C1 [nucleoplasm] (R-HSA-5578686) EIF2C1 [cytosol] (R-HSA-210616)	0.527	4
UniProt:Q13283 G3BP1	1	G3BP1 [cytosol] (R-HSA-9729517)	0.527	2
UniProt:P59595 N	9	N [cytosol] (R-COV-9683625) p-S177-N [cytosol] (R-COV-9683754) ADPr-p-S177-N [cytosol] (R-COV-9686058) SUMO1-K62-ADPr-p-S177-N [cytosol] (R-COV-9682916) SUMO1-K62-ADPr-p-S177-N [viral capsid] (R-COV-9685478) SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9683641) N [plasma membrane] (R-COV-9683611) SUMO1-K62-ADPr-p-S177-N [nucleolus] (R-COV-9683730) SUMO1-K62-ADPr-p-S177-N [plasma membrane] (R-COV-9686063)	0.527	2
UniProt:Q9NZI8 IGF2BP1	1	IGF2BP1 [cytosol] (R-HSA-428366)	0.527	3
UniProt:Q15365 PCBP1	1	PCBP1 [nucleoplasm] (R-HSA-71919)	0.527	2
UniProt:Q8WWM7 ATX2L			0.527	4
UniProt:Q15366 PCBP2	2	PCBP2 [cytosol] (R-HSA-983457) PCBP2 [nucleoplasm] (R-HSA-71921)	0.527	2
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	2
UniProt:O95503 CBX6	1	CBX6 [nucleoplasm] (R-HSA-3229071)	0.527	2
UniProt:Q9Y5S9 RBM8A	2	RBM8A [cytosol] (R-HSA-162462) RBM8A [nucleoplasm] (R-HSA-156659)	0.527	2
UniProt:P33469 NCAP			0.527	2
UniProt:P13693 TCTP			0.527	2
UniProt:P60842 EIF4A1	1	EIF4A1 [cytosol] (R-HSA-72573)	0.527	3
UniProt:O55778 PHOSP			0.524	2
UniProt:Q96Q15 SMG1	1	SMG1 [cytosol] (R-HSA-927760)	0.499	2
UniProt:P35568 IRS1	5	p-Y-IRS1 [plasma membrane] (R-HSA-198366) p-Y-IRS1 [cytosol] (R-HSA-74772) IRS1 [cytosol] (R-HSA-74769) IRS1 [plasma membrane] (R-HSA-2425392) p-6Y-IRS1 [plasma membrane] (R-HSA-2445090)	0.499	2
UniProt:Q86U42 PABPN1	2	PABPN1 [cytosol] (R-HSA-9822424) PABPN1 [nucleoplasm] (R-HSA-72008)	0.499	2
UniProt:Q9J0X9 Q9J0X9			0.499	3
UniProt:P0C6U8-PRO_0000338257			0.499	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2

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