Reactome | Ub-C86-UBE2L3 [nucleoplasm]

Ub-C86-UBE2L3 [nucleoplasm]

Stable Identifier

R-HSA-8864226

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Ubiquitin-conjugating enzyme E2 L3 ecNumber evidence="18"2.3.2.23/ecNumber, UB2L3_HUMAN

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Protein ubiquitination (Homo sapiens)
    - Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
      - UBA1 conjugates ubiquitin to nuclear E2 enzymes (Homo sapiens)
        
        Ub:E2 (UBA1 substrate) [nucleoplasm] (Homo sapiens)
        
        Ub-conjugated E2 enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)
        
        Ub-C86-UBE2L3 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P68036 UBE2L3

Gene Names

UBE2L3, UBCE7, UBCH7

Chain

chain:1-154

Reference Genes

BioGPS Gene:7332 UBE2L3

COSMIC (genes):UBE2L3 UBE2L3

CTD Gene:7332 UBE2L3

dbSNP Gene:7332 UBE2L3

ENSEMBL:ENSG00000185651 UBE2L3

HGNC:12488 UBE2L3

KEGG:hsa:7332 UBE2L3

Monarch:7332 UBE2L3

NCBI Gene:7332 UBE2L3

OMIM:603721 UBE2L3

UCSC:P68036 UBE2L3

Reference Transcript

Participates

as a member of

Ub-conjugated E2 enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)

Other forms of this molecule

Ub-C86-UBE2L3 [cytosol]

UBE2L3 [cytosol]

UBE2L3 [nucleoplasm]

Inferred To

Ube2l3 [nucleoplasm] (Mus musculus)

Ube2l3 [nucleoplasm] (Rattus norvegicus)

ube2l3b [nucleoplasm] (Danio rerio)

ube2l3 [nucleoplasm] (Xenopus tropicalis)

UBE2L3 [nucleoplasm] (Bos taurus)

UBE2L3 [nucleoplasm] (Canis familiaris)

UBE2L3 [nucleoplasm] (Gallus gallus)

UBE2L3 [nucleoplasm] (Sus scrofa)

Ub-C86-UBE2L3 [nucleoplasm] (Dictyostelium discoideum)

Ub-C86-UBE2L3 [nucleoplasm] (Plasmodium falciparum)

ubc-18 [nucleoplasm] (Caenorhabditis elegans)

Ubc10 [nucleoplasm] (Drosophila melanogaster)

ubcB [nucleoplasm] (Dictyostelium discoideum)

Homologues of Ub-C86-UBE2L3 [nucleoplasm] (Dictyostelium discoideum)

Modified Residues

Name

S-(glycyl)-L-cysteine (Cys-Gly) at 86

Coordinate

PsiMod Name

S-(glycyl)-L-cysteine (Cys-Gly)

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Cross References

RefSeq

NP_001243284.1, NP_003338.1, NP_001243285.1

OpenTargets

ENSG00000185651

ENSEMBL

ENSP00000344259, ENSP00000400906, ENSP00000445931, ENSG00000185651, ENST00000342192, ENST00000458578, ENST00000545681

HPA

ENSG00000185651-UBE2L3

GeneCards

UBE2L3

PRO

P68036

Pharos - Targets

P68036

Orphanet

UBE2L3

GlyGen

P68036

HMDB Protein

HMDBP00601

PDB

3SY2, 7B5N, 5UDH, 6N13, 7B5L, 8EAZ, 5TTE, 1FBV, 7V8F, 3SQV, 4Q5E, 6DJX, 7OIK, 5HPT, 1C4Z, 6DJW, 4Q5H, 6XXU, 8EB0, 6CP2

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95376 ARIH2	1	ARIH2 [cytosol] (R-HSA-975987)	0.884	12
UniProt:Q9BYM8 RBCK1	1	RBCK1 [cytosol] (R-HSA-976018)	0.666	4
UniProt:P50876 RNF144A	1	RNF144A [endosome membrane] (R-HSA-8938771)	0.666	4
UniProt:O15344 MID1	1	MID1 [cytosol] (R-HSA-976027)	0.666	4
UniProt:Q9Y4X5 ARIH1	1	ARIH1 [cytosol] (R-HSA-1678825)	0.643	7
UniProt:Q99PZ6 OSPG			0.558	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:Q9NWF9 RNF216	1	RNF216 [cytosol] (R-HSA-936043)	0.556	3
UniProt:O60260-5 PRKN			0.556	3
IntAct:EBI-23192465 CCSB ORF ID			0.556	3
UniProt:Q8N6D2 RNF182	1	RNF182 [cytosol] (R-HSA-976010)	0.556	3
UniProt:O94941 UBOX5	1	UBOX5 [cytosol] (R-HSA-976034)	0.547	2
UniProt:Q6ZMZ0 RNF19B	1	RNF19B [cytosol] (R-HSA-975969)	0.524	2
UniProt:Q96EQ8 RNF125	2	RNF125 [cytosol] (R-HSA-918184) K48polyUb-RNF125 [cytosol] (R-HSA-3080560)	0.488	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	6
UniProt:Q9NPC3 CIP1			0.482	2

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