Reactome | LARS [cytosol]

LARS [cytosol]

Stable Identifier

R-HSA-379680

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Leucyl-tRNA synthetase

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9P2J5 LARS1

Gene Names

LARS1, KIAA1352, LARS

Chain

chain:1-1176

Reference Genes

BioGPS Gene:51520 LARS1

CTD Gene:51520 LARS1

dbSNP Gene:51520 LARS1

ENSEMBL:ENSG00000133706 LARS

ENSEMBL_homo_sapiens_GENE:ENSG00000133706.20 LARS1

HGNC:6512 LARS1

KEGG Gene (Homo sapiens):51520 LARS1

Monarch:51520 LARS1

NCBI Gene:51520 LARS1

OMIM:151350 LARS1

UCSC:Q9P2J5 LARS1

Reference Transcript

Other Identifiers

11735991_at

11735992_a_at

11750272_a_at

17001197

217810_PM_x_at

217810_x_at

222427_PM_s_at

222427_s_at

222428_PM_s_at

222428_s_at

223888_PM_s_at

223888_s_at

2879926

2879928

2879929

2879930

2879931

2879932

2879933

2879935

2879936

2879937

2879938

2879939

2879940

2879941

2879942

2879944

2879946

2879947

2879948

2879951

2879954

2879956

2879957

2879959

2879960

2879961

2879965

2879966

2879967

2879968

2879969

2879970

2879971

2879972

2879973

2879974

2879976

2879977

2879978

2879981

2879983

2879984

51520

54061_at

61729_r_at

8114861

A_24_P51360

A_33_P3531828

GE53925

GE82129

GO:0000166

GO:0002161

GO:0003824

GO:0004812

GO:0004819

GO:0004823

GO:0005096

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005764

GO:0005773

GO:0005783

GO:0005829

GO:0006399

GO:0006412

GO:0006418

GO:0006425

GO:0006429

GO:0006520

GO:0008361

GO:0012505

GO:0016604

GO:0016787

GO:0016874

GO:0017101

GO:0023052

GO:0032008

GO:0034198

GO:0043226

GO:0043547

GO:0071230

GO:0071233

GO:0098772

GO:0106074

GO:0140098

GO:1904263

GO:1990253

HMNXSV003021197

Hs.6762.0.A1_3p_a_at

ILMN_1757317

PH_hs_0025253

TC05001900.hg

TC05003291.hg

g7106773_3p_s_at

g7804449_3p_a_at

Participates

as a component of

Inferred To

Lars1 [cytosol] (Rattus norvegicus)

LARS1 [cytosol] (Bos taurus)

LARS1 [cytosol] (Canis familiaris)

LARS1 [cytosol] (Sus scrofa)

LeuRS [cytosol] (Drosophila melanogaster)

LARS [cytosol] (Dictyostelium discoideum)

LARS [cytosol] (Gallus gallus)

LARS [cytosol] (Mus musculus)

Cross References

RefSeq

NP_001304894.1, NP_001304893.1, NP_064502.9, XP_011535958.1, NP_057544.2

OpenTargets

ENSG00000133706

ZINC - Substances

SYLC_HUMAN

ZINC target

Q9P2J5

PRO

Q9P2J5

PDB

6LR6, 6KQY, 2WFD, 6KIE, 6LPF, 6KR7, 6KID

HPA

ENSG00000133706-LARS1

GeneCards

Q9P2J5

Ensembl

ENST00000394434, ENSP00000501434, ENST00000674174, ENSP00000377954, ENSG00000133706, ENST00000510191, ENSP00000426005

Pharos - Targets

Q9P2J5

ZINC - Predictions - Purchasable

SYLC_HUMAN

Orphanet

22570

HMDB Protein

HMDBP00648

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.527	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	6