Reactome | p-CLINT1 [cytosol]

p-CLINT1 [cytosol]

Stable Identifier

R-HSA-429811

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

T294-phosphorylated Clathrin interactor 1, EPN4_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
35452674	The cargo adapter protein CLINT1 is phosphorylated by the Numb-associated kinase BIKE and mediates dengue virus infection Schor, S, Pu, S, Nicolaescu, V, Azari, S, Kõivomägi, M, Karim, M, Cassonnet, P, Saul, S, Neveu, G, Yueh, A, Demeret, C, Skotheim, JM, Jacob, Y, Randall, G, Einav, S	J Biol Chem	2022

External Reference Information

External Reference

UniProt:Q14677 CLINT1

Gene Names

CLINT1, ENTH, EPN4, EPNR, KIAA0171

Chain

chain:1-625

Reference Genes

BioGPS Gene:9685 CLINT1

COSMIC (genes):CLINT1 CLINT1

CTD Gene:9685 CLINT1

dbSNP Gene:9685 CLINT1

ENSEMBL:ENSG00000113282 CLINT1

HGNC:23186 CLINT1

KEGG:hsa:9685 CLINT1

Monarch:9685 CLINT1

NCBI Entrez Gene:9685 CLINT1

OMIM:607265 CLINT1

UCSC:Q14677 CLINT1

Reference Transcript

Other Identifiers

11723953_a_at

11723954_s_at

11723955_a_at

11746066_a_at

17002240

201768_PM_s_at

201768_s_at

201769_PM_at

201769_at

230609_PM_at

230609_at

2883610

2883611

2883612

2883613

2883614

2883617

2883618

2883619

2883620

2883621

2883622

2883623

2883624

2883625

2883630

2883631

2883636

2883637

2883638

2883639

2883640

2883641

2883642

2883654

2883655

2883656

40128_at

57835_at

74838_s_at

74841_r_at

8115524

84736_at

9685

A_23_P133345

A_24_P12149

D79993_at

GE57310

GE781450

GO:0005515

GO:0005543

GO:0005654

GO:0005737

GO:0005768

GO:0005794

GO:0005829

GO:0005886

GO:0006897

GO:0008289

GO:0012505

GO:0016020

GO:0016192

GO:0030125

GO:0030136

GO:0030276

GO:0031410

GO:0045296

GO:0048268

GO:0048471

GO:0065003

HMNXSV003048496

Hs.132853.0.A1_3p_at

ILMN_1745076

PH_hs_0029181

TC05001989.hg

g13325306_3p_a_at

g7661967_3p_at

Participates

as a component of

Golgi-associated vesicle interacting proteins [cytosol] (Homo sapiens)

as an input of

Recruitment Of Cytoplasmic Proteins To Vesicles (Homo sapiens)

Inferred To

phospho-p-CLINT1 [cytosol] (Bos taurus)

phospho-p-CLINT1 [cytosol] (Gallus gallus)

phospho-p-CLINT1 [cytosol] (Mus musculus)

phospho-p-CLINT1 [cytosol] (Plasmodium falciparum)

phospho-p-CLINT1 [cytosol] (Schizosaccharomyces pombe)

phospho-p-CLINT1 [cytosol] (Sus scrofa)

phospho-lqfR [cytosol] (Drosophila melanogaster)

phospho-rsd-3 [cytosol] (Caenorhabditis elegans)

phospho-CLINT1 [cytosol] (Canis familiaris)

phospho-ENT3 [cytosol] (Saccharomyces cerevisiae)

phospho-Clint1 [cytosol] (Rattus norvegicus)

phospho-clint1a [cytosol] (Danio rerio)

phospho-epnA [cytosol] (Dictyostelium discoideum)

phospho-clint1 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-threonine at 294

Coordinate

294

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001182485.1, NP_001182484.1, NP_055481.1

OpenTargets

ENSG00000113282

ENSEMBL

ENSP00000388340, ENST00000530742, ENSP00000429824, ENST00000523094, ENSG00000113282, ENSP00000433419, ENST00000411809, ENSP00000429345, ENST00000523908

HPA

ENSG00000113282-CLINT1

GeneCards

CLINT1

PRO

Q14677

Pharos - Targets

Q14677

GlyGen

Q14677

PDB

2V8S, 2QY7, 1XGW

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NSY1 BMP2K			0.715	7
UniProt:O88384	2	Vti1b [extracellular region] (R-MMU-8862983) Vti1b [platelet alpha granule lumen] (R-MMU-8862964)	0.645	6
UniProt:Q9UEU0 VTI1B	2	VTI1B [extracellular region] (R-HSA-8862983) VTI1B [platelet alpha granule lumen] (R-HSA-8862964)	0.615	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:Q8WTR4-3 GDPD5			0.556	3
UniProt:P22892	5	Ap1g1 [cytoplasmic vesicle membrane] (R-MMU-351194) Ap1g1 [Golgi membrane] (R-MMU-350808) Ap1g1 [lysosomal membrane] (R-MMU-432693) Ap1g1 [trans-Golgi network membrane] (R-MMU-2130340) Ap1g1 [cytosol] (R-MMU-167703)	0.544	10
UniProt:O95630 STAMBP	1	STAMBP [cytosol] (R-HSA-5693063)	0.527	2
UniProt:O00443 PIK3C2A	3	PIK3C2A [cytosol] (R-HSA-1604624) PIK3C2A [cytoplasmic vesicle membrane] (R-HSA-432683) PIK3C2A [Golgi membrane] (R-HSA-432679)	0.527	3
UniProt:Q96FJ0 STAMBPL1	1	STAMBPL1 [cytosol] (R-HSA-6783264)	0.527	2
UniProt:Q9UNK0 STX8			0.527	2
UniProt:P09497 CLTB	5	CLTB [cytosol] (R-HSA-8856819) CLTB [trans-Golgi network membrane] (R-HSA-5333645) CLTB [clathrin-coated endocytic vesicle membrane] (R-HSA-5138428) CLTB [lysosomal membrane] (R-HSA-2980616) CLTB [plasma membrane] (R-HSA-2980617)	0.527	2
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [cytosol] (R-HSA-5205651) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [autophagosome membrane] (R-HSA-5683641)	0.525	2
UniProt:Q9H0R8 GABARAPL1	3	GABARAPL1 [cytosol] (R-HSA-5671757) GABARAPL1(1-117) [cytosol] (R-HSA-5682659) GABARAPL1 [autophagosome membrane] (R-HSA-5683637)	0.525	2
UniProt:Q96FJ2 DYNLL2	4	DYNLL2 [cytosol] (R-HSA-2029024) DYNLL2 [plasma membrane] (R-HSA-140527) DYNLL2 [cilium] (R-HSA-5624865) DYNLL2 [ciliary tip] (R-HSA-5625337)	0.508	2
UniProt:P29991-PRO_0000037943			0.508	2
UniProt:P63167 DYNLL1	6	DYNLL1 [cytosol] (R-HSA-387105) DYNLL1 [plasma membrane] (R-HSA-54017) DYNLL1 [tertiary granule membrane] (R-HSA-6801482) DYNLL1 [ficolin-1-rich granule membrane] (R-HSA-6801518) DYNLL1 [cilium] (R-HSA-5624863) DYNLL1 [ciliary tip] (R-HSA-5625335)	0.508	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	8

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