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PXLP-K280-SHMT2 [mitochondrial inner membrane]
Stable Identifier
R-HSA-5694086
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial inner membrane
Synonyms
Serine hydroxymethyltransferase, mitochondrial, GLYM_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Metabolism of folate and pterines (Homo sapiens)
PXLP-K280-SHMT2 tetramer transfers CH2OH group to Gly to form L-Ser (Homo sapiens)
PXLP-K280-SHMT2 tetramer [mitochondrial inner membrane] (Homo sapiens)
PXLP-K280-SHMT2 [mitochondrial inner membrane] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Mitochondrial protein degradation (Homo sapiens)
LONP1 binds mitochondrial inner membrane proteins (Homo sapiens)
LONP1:substrate protein (mitochondrial inner membrane) [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
PXLP-K280-SHMT2 [mitochondrial inner membrane] (Homo sapiens)
Substrate of LONP1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
PXLP-K280-SHMT2 [mitochondrial inner membrane] (Homo sapiens)
LONP1 degrades mitochondrial inner membrane proteins (Homo sapiens)
LONP1:substrate protein (mitochondrial inner membrane) [mitochondrial matrix] (Homo sapiens)
Substrate of LONP1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
PXLP-K280-SHMT2 [mitochondrial inner membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P34897 SHMT2
Gene Names
SHMT2
Chain
transit peptide:1-29, chain:30-504
Reference Genes
BioGPS Gene:6472 SHMT2
COSMIC (genes):SHMT2 SHMT2
CTD Gene:6472 SHMT2
dbSNP Gene:6472 SHMT2
ENSEMBL:ENSG00000182199 SHMT2
ENSEMBL_homo_sapiens_GENE:ENSG00000182199.11 SHMT2
HGNC:10852 SHMT2
KEGG Gene (Homo sapiens):6472 SHMT2
Monarch:6472 SHMT2
NCBI Gene:6472 SHMT2
OMIM:138450 SHMT2
UCSC:P34897 SHMT2
Reference Transcript
RefSeq:NM_001166356.1 SHMT2
RefSeq:NM_001166357.1 SHMT2
RefSeq:NM_001166358.1 SHMT2
RefSeq:NM_001166359.1 SHMT2
RefSeq:NM_005412.5 SHMT2
Other Identifiers
11746438_a_at
11747537_x_at
11750992_x_at
11756615_x_at
16752834
214095_PM_at
214095_at
214096_PM_s_at
214096_s_at
214437_3p_s_at
214437_PM_s_at
214437_s_at
3418009
3418010
3418011
3418012
3418013
3418014
3418015
3418016
3418017
3418018
3418019
3418021
3418023
3418024
3418027
3418028
3418032
3418034
3418035
3418037
3418039
3418040
3418041
3418042
36178_at
6472
7956401
A_14_P122852
A_23_P158239
A_23_P169629
GE59018
GO:0000900
GO:0002082
GO:0002376
GO:0003682
GO:0003723
GO:0003824
GO:0004372
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005739
GO:0005743
GO:0005759
GO:0005829
GO:0005856
GO:0006091
GO:0006520
GO:0006544
GO:0006545
GO:0006563
GO:0006564
GO:0006565
GO:0006575
GO:0006730
GO:0006766
GO:0008168
GO:0008270
GO:0008284
GO:0008732
GO:0009113
GO:0015630
GO:0016020
GO:0016597
GO:0016740
GO:0016829
GO:0017148
GO:0019264
GO:0030170
GO:0032259
GO:0034340
GO:0035999
GO:0036211
GO:0042645
GO:0042802
GO:0042803
GO:0043226
GO:0045182
GO:0046653
GO:0046655
GO:0048027
GO:0051262
GO:0051289
GO:0055086
GO:0065003
GO:0070062
GO:0070129
GO:0070536
GO:0070552
GO:0070905
GO:0098542
GO:0140053
GO:1903715
HMNXSV003011419
Hs.2186.4.A1_3p_a_at
Hs.2186.4.A1_3p_x_at
Hs.75069.0.S1_3p_x_at
ILMN_1661264
PH_hs_0004269
PH_hs_0031312
TC12000525.hg
TC12002398.hg
U23143_at
Participates
as a member of
Substrate of LONP1 (mitochondrial inner membrane) [mitochondrial inner membrane] (Homo sapiens)
as a component of
PXLP-K280-SHMT2 tetramer [mitochondrial inner membrane] (Homo sapiens)
Other forms of this molecule
SHMT2 [cytosol]
Inferred To
Shmt2 [mitochondrial inner membrane]
(Mus musculus)
Shmt2 [mitochondrial inner membrane]
(Rattus norvegicus)
Homologues of PXLP-K280-SHMT2 [mitochondrial inner membrane]
(Plasmodium falciparum)
PXLP-K280-SHMT2 [mitochondrial inner membrane]
(Danio rerio)
PXLP-K280-SHMT2 [mitochondrial inner membrane]
(Plasmodium falciparum)
shmt2 [mitochondrial inner membrane]
(Xenopus tropicalis)
SHMT2 [mitochondrial inner membrane]
(Bos taurus)
SHMT2 [mitochondrial inner membrane]
(Canis familiaris)
SHMT2 [mitochondrial inner membrane]
(Sus scrofa)
shmt1 [mitochondrial inner membrane]
(Dictyostelium discoideum)
Modified Residues
Name
N6-pyridoxal phosphate-L-lysine at 280
Coordinate
280
PsiMod Name
N6-pyridoxal phosphate-L-lysine [MOD:00128]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.
Cross References
RefSeq
NP_001159828.1
,
NP_001159831.1
,
NP_005403.2
,
NP_001159829.1
,
NP_001159830.1
OpenTargets
ENSG00000182199
HPA
ENSG00000182199-SHMT2
GeneCards
P34897
Ensembl
ENST00000449049
,
ENST00000553474
,
ENSP00000413770
,
ENSP00000333667
,
ENSP00000452419
,
ENSP00000406881
,
ENST00000414700
,
ENST00000328923
,
ENSG00000182199
,
ENST00000557487
,
ENSP00000452315
PRO
P34897
Pharos - Targets
P34897
Orphanet
27044
HMDB Protein
HMDBP00792
PDB
4PVF
,
6DK3
,
8AQL
,
8FJU
,
5X3V
,
8SSJ
,
8QI7
,
6H3C
,
5V7I
,
6R8F
,
6M5O
,
6QVG
,
8FJT
,
6QVL
,
7BYI
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
10
UniProt:P46736 BRCC3
2
BRCC3 [cytosol]
(R-HSA-5691415)
BRCC3 [nucleoplasm]
(R-HSA-5682577)
0.589
2
UniProt:Q9NXR7 BRE
2
BRE [cytosol]
(R-HSA-5691413)
BRE [nucleoplasm]
(R-HSA-5682579)
0.564
2
UniProt:Q9NWV8 BABAM1
2
BABAM1 [cytosol]
(R-HSA-5691418)
BABAM1 [nucleoplasm]
(R-HSA-5682582)
0.564
2
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