Reactome | CBR1 [cytosol]

CBR1 [cytosol]

Stable Identifier

R-HSA-2142784

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Carbonyl reductase (NADPH)1, CBR1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P16152 CBR1

Gene Names

CBR1, CBR, CRN, SDR21C1

Chain

initiator methionine:1, chain:2-277

Reference Genes

BioGPS Gene:873 CBR1

COSMIC (genes):CBR1 CBR1

CTD Gene:873 CBR1

dbSNP Gene:873 CBR1

ENSEMBL:ENSG00000159228 CBR1

HGNC:1548 CBR1

KEGG Gene (Homo sapiens):873 CBR1

Monarch:873 CBR1

NCBI Gene:873 CBR1

OMIM:114830 CBR1

UCSC:P16152 CBR1

Reference Transcript

Other Identifiers

0001580541

11729715_a_at

11729716_s_at

11746036_s_at

11753301_a_at

11753302_s_at

11760235_a_at

11760236_at

16922477

209213_at

38773_at

3919787

3919788

3919791

3919792

3919793

3919794

3919795

3919796

3919798

8068401

873

A_14_P107766

A_23_P29046

A_33_P3284394

GE57495

GO:0003674

GO:0004090

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005829

GO:0006629

GO:0008150

GO:0009058

GO:0016491

GO:0016655

GO:0017144

GO:0019371

GO:0030154

GO:0030855

GO:0042373

GO:0043226

GO:0044281

GO:0047020

GO:0047021

GO:0048856

GO:0050221

GO:0055114

GO:0070062

GO:1903561

ILMN_1809003

J04056_at

PH_hs_0004964

PH_hs_0031394

TC21000148.hg

g12803380_3p_at

Inferred To

Homologues of CBR1 [cytosol] (Bos taurus)

Homologues of CBR1 [cytosol] (Sus scrofa)

LOC100622246 [cytosol] (Sus scrofa)

Cbr1 [cytosol] (Mus musculus)

Cbr1 [cytosol] (Rattus norvegicus)

LOC610164 [cytosol] (Canis familiaris)

MGC127133 [cytosol] (Bos taurus)

cbr1.1 [cytosol] (Xenopus tropicalis)

LOC112441473 [cytosol] (Bos taurus)

CBR1 [cytosol] (Sus scrofa)

cbr1 [cytosol] (Danio rerio)

CBR3 [cytosol] (Gallus gallus)

Cross References

RefSeq

NP_001273718.1, NP_001748.1

ZINC - World Drugs

CBR1_HUMAN

OpenTargets

ENSG00000159228

ZINC - FDA approved

CBR1_HUMAN

ZINC - Substances

CBR1_HUMAN

ZINC target

P16152

ZINC - Biogenic

CBR1_HUMAN

PRO

P16152

PDB

1WMA, 3BHJ, 3BHI, 4Z3D, 2PFG, 3BHM

ZINC - Metabolites

CBR1_HUMAN

HPA

ENSG00000159228-CBR1

GeneCards

P16152

Ensembl

ENST00000530908, ENST00000290349, ENSP00000290349, ENSP00000434613, ENSG00000159228

ZINC - Predictions - Purchasable

CBR1_HUMAN

HMDB Protein

HMDBP00075

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y478 PRKAB1	2	PRKAB1 [cytosol] (R-HSA-380968) PRKAB1 [nucleoplasm] (R-HSA-2151199)	0.589	2
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.553	2
UniProt:O75828 CBR3	1	CBR3 [cytosol] (R-HSA-8937409)	0.527	2

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