Reactome | p-T183-PRKAA1 [cytosol]

p-T183-PRKAA1 [cytosol]

Stable Identifier

R-HSA-380964

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-T183-AMPK alpha1

Locations in the PathwayBrowser

Expand all

Autophagy (Homo sapiens)

- Macroautophagy (Homo sapiens)
  - AMPK (complex) phosphorylates ULK1 (complex) (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T183-PRKAA1 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T183-PRKAA1 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T183-PRKAA1 [cytosol] (Homo sapiens)
  - Thr-180 of ULK1 is phosphorylated (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T183-PRKAA1 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T183-PRKAA1 [cytosol] (Homo sapiens)
  - ULK complex translocates to the ER (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T183-PRKAA1 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T183-PRKAA1 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates AMBRA1:BECN1 complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T183-PRKAA1 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates ATG13 and RB1CC1 (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T183-PRKAA1 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T183-PRKAA1 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates Beclin-1 (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T183-PRKAA1 [cytosol] (Homo sapiens)
  - p-AMPK:AMP binds the ULK complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T183-PRKAA1 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T183-PRKAA1 [cytosol] (Homo sapiens)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T183-PRKAA1 [cytosol] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Metabolic Genes (Homo sapiens)
        
        SESN1,2,3 bind AMPK (Homo sapiens)
        
        SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T183-PRKAA1 [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T183-PRKAA1 [cytosol] (Homo sapiens)
        
        p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T183-PRKAA1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13131 PRKAA1

Gene Names

PRKAA1, AMPK1

Chain

chain:1-559

Reference Genes

BioGPS Gene:5562 PRKAA1

COSMIC (genes):PRKAA1 PRKAA1

CTD Gene:5562 PRKAA1

dbSNP Gene:5562 PRKAA1

ENSEMBL:ENSG00000132356 PRKAA1

HGNC:9376 PRKAA1

KEGG:hsa:5562 PRKAA1

Monarch:5562 PRKAA1

NCBI Gene:5562 PRKAA1

OMIM:602739 PRKAA1

UCSC:Q13131 PRKAA1

Reference Transcript

Other Identifiers

11729314_a_at

11739209_a_at

11751517_a_at

11762210_at

1555177_PM_at

1555177_at

16995685

209799_PM_at

209799_at

225984_PM_at

225984_at

225985_PM_at

225985_at

2854734

2854736

2854738

2854739

2854740

2854741

2854742

2854743

2854744

2854745

2854746

2854747

2854748

2854749

2854750

2854751

2854752

2854753

2854755

2854758

2854760

2854761

2854762

2854763

2854764

2854765

2854776

2854777

2854778

2854779

41015_at

48068_at

5562

8111796

A_23_P110725

A_33_P3257187

A_33_P3312212

GE53597

GE878012

GE895807

GO:0000785

GO:0001666

GO:0002842

GO:0003682

GO:0003824

GO:0004672

GO:0004674

GO:0004679

GO:0004691

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005975

GO:0006006

GO:0006325

GO:0006338

GO:0006355

GO:0006468

GO:0006629

GO:0006633

GO:0006695

GO:0006914

GO:0007165

GO:0008092

GO:0008284

GO:0008610

GO:0009410

GO:0009411

GO:0009631

GO:0010332

GO:0010508

GO:0010628

GO:0010629

GO:0014823

GO:0016055

GO:0016324

GO:0016607

GO:0016740

GO:0019395

GO:0030424

GO:0030425

GO:0031000

GO:0031588

GO:0031669

GO:0032007

GO:0032991

GO:0033135

GO:0034599

GO:0042149

GO:0042542

GO:0042593

GO:0042752

GO:0043025

GO:0043066

GO:0043226

GO:0043627

GO:0044877

GO:0045542

GO:0045821

GO:0045893

GO:0046318

GO:0046627

GO:0046872

GO:0047322

GO:0048156

GO:0048511

GO:0048643

GO:0050321

GO:0050870

GO:0050995

GO:0055089

GO:0060627

GO:0061744

GO:0061762

GO:0062028

GO:0070050

GO:0070301

GO:0070507

GO:0071277

GO:0071333

GO:0071361

GO:0071380

GO:0071456

GO:0071466

GO:0097009

GO:0106310

GO:0140096

GO:0140823

GO:1903109

GO:1903829

GO:1903944

GO:1903955

GO:1904179

GO:1904262

GO:1904428

GO:1905691

GO:1990044

GO:2000758

HMNXSV003036598

Hs.107057.0.A1_3p_at

Hs.107057.0.A2_3p_at

Hs2.9247.2.S1_3p_at

ILMN_1783889

ILMN_2357577

PH_hs_0022119

TC05001298.hg

Y12856_at

g5410311_3p_at

Participates

as a member of

p-AMPK alpha [cytosol] (Homo sapiens)

Other forms of this molecule

PRKAA1 [cytosol]

p-T183-PRKAA1 [nucleoplasm]

Inferred To

Homologues of p-T183-PRKAA1 [cytosol] (Caenorhabditis elegans)

Homologues of p-T183-PRKAA1 [cytosol] (Dictyostelium discoideum)

Homologues of p-T183-PRKAA1 [cytosol] (Saccharomyces cerevisiae)

Homologues of p-T183-PRKAA1 [cytosol] (Schizosaccharomyces pombe)

phospho-p-T183-PRKAA1 [cytosol] (Bos taurus)

phospho-p-T183-PRKAA1 [cytosol] (Caenorhabditis elegans)

phospho-p-T183-PRKAA1 [cytosol] (Danio rerio)

phospho-p-T183-PRKAA1 [cytosol] (Dictyostelium discoideum)

phospho-p-T183-PRKAA1 [cytosol] (Drosophila melanogaster)

phospho-p-T183-PRKAA1 [cytosol] (Gallus gallus)

phospho-p-T183-PRKAA1 [cytosol] (Mus musculus)

phospho-p-T183-PRKAA1 [cytosol] (Saccharomyces cerevisiae)

phospho-p-T183-PRKAA1 [cytosol] (Schizosaccharomyces pombe)

p-T183-Prkaa1 [cytosol] (Rattus norvegicus)

Modified Residues

Name

O-phospho-L-threonine at 183

Coordinate

183

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_996790.3, NP_006242.5

Guide to Pharmacology - Targets

1541

OpenTargets

ENSG00000132356

ENSEMBL

ENST00000397128, ENSP00000346148, ENSP00000380317, ENST00000354209

IntEnz

2.7.11.31, 2.7.11.26

HPA

ENSG00000132356-PRKAA1

ZINC target

Q13131

PRO

Q13131

Pharos - Targets

Q13131

GlyGen

Q13131

HMDB Protein

HMDBP01899

PDB

4REW, 7JHG, 6C9J, 4RED, 7JIJ, 5EZV, 6C9H, 6C9F, 7M74, 7JHH, 6C9G, 4RER

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75385 ULK1	7	ULK1 [cytosol] (R-HSA-1632847) ULK1 [mitochondrial outer membrane] (R-HSA-8948145) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) p-S758-ULK1 [cytosol] (R-HSA-5672131) ULK1 [recycling endosome] (R-HSA-8854761)	0.669	3
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.643	3
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.564	2
UniProt:P46937 YAP1	8	YAP1 [nucleoplasm] (R-HSA-1253322) YAP1 [cytosol] (R-HSA-1253345) p-S127-YAP1 [cytosol] (R-HSA-2028553) p-5S-YAP1 [cytosol] (R-HSA-2028554) p-Y-YAP1 [nucleoplasm] (R-HSA-8937857) p-Y-YAP1 [cytosol] (R-HSA-8937843) p-Y407-YAP1 [nucleoplasm] (R-HSA-8956661) p-Y407-YAP1 [cytosol] (R-HSA-9865208)	0.564	3
UniProt:O96006 ZBED1	1	ZBED1 [nucleoplasm] (R-HSA-8956376)	0.556	3
UniProt:Q08379 GOLGA2	3	p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [cytosol] (R-HSA-8851002) TRIM27 [nucleoplasm] (R-HSA-2997690)	0.556	3
UniProt:O14503 BHLHE40	1	BHLHE40 [nucleoplasm] (R-HSA-879741)	0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.527	2
UniProt:P54646 PRKAA2	4	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.527	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	3