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SDHA [mitochondrial matrix]
Stable Identifier
R-HSA-9854690
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
Succinate Dehydrogenase complex subunit A, Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial, Fp, Flavoprotein subunit of complex II
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Citric acid cycle (TCA cycle) (Homo sapiens)
Maturation of TCA enzymes and regulation of TCA cycle (Homo sapiens)
FAD attaches to SDHA (Homo sapiens)
SDHA [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:P31040 SDHA
Gene Names
SDHA, SDH2, SDHF
Chain
transit peptide:1-42, chain:43-664
Reference Genes
BioGPS Gene:6389 SDHA
COSMIC (genes):SDHA SDHA
CTD Gene:6389 SDHA
dbSNP Gene:6389 SDHA
ENSEMBL:ENSG00000073578 SDHA
HGNC:10680 SDHA
KEGG:hsa:6389 SDHA
Monarch:6389 SDHA
NCBI Gene:6389 SDHA
OMIM:600857 SDHA
UCSC:P31040 SDHA
Reference Transcript
RefSeq:NM_004168.3 SDHA
RefSeq:NM_001294332.1 SDHA
Other Identifiers
11744078_s_at
11747868_x_at
11749757_x_at
11760250_at
201093_PM_x_at
201093_x_at
222021_3p_x_at
222021_PM_x_at
222021_x_at
2659053
2659056
2659064
2659077
2659079
2659080
2659090
2659092
2712552
2712554
2712556
2712567
2712569
2712586
2713507
2798539
2798540
2798541
2798543
2798544
2798545
2798546
2798547
2798548
2798549
2798550
2798553
2798557
2798558
2798559
2798560
2798564
2798565
2798566
2798567
2798568
2798569
2798570
2798571
2798575
2798577
2846061
2846065
2846066
2846067
2846068
2846069
2846071
2846072
2846073
2846088
34826_at
6389
8093039
8104166
A_23_P250035
GE57675
GO:0003824
GO:0005515
GO:0005730
GO:0005739
GO:0005743
GO:0005759
GO:0006091
GO:0006099
GO:0006105
GO:0006121
GO:0007399
GO:0008177
GO:0009055
GO:0016020
GO:0016491
GO:0016627
GO:0022900
GO:0022904
GO:0042776
GO:0043226
GO:0045273
GO:0048856
GO:0050660
GO:0055086
GO:1901135
HMNXSV003018881
HMNXSV003039244
HMNXSV003052645
ILMN_1651664
ILMN_1671972
ILMN_1734640
ILMN_1744210
L21936_at
PH_hs_0039736
g4759079_3p_s_at
Participates
as an input of
FAD attaches to SDHA (Homo sapiens)
Other forms of this molecule
FAD-SDHA [mitochondrial matrix]
Inferred To
SDHA [mitochondrial matrix]
(Bos taurus)
SDHA [mitochondrial matrix]
(Caenorhabditis elegans)
SDHA [mitochondrial matrix]
(Canis familiaris)
SDHA [mitochondrial matrix]
(Danio rerio)
SDHA [mitochondrial matrix]
(Dictyostelium discoideum)
SDHA [mitochondrial matrix]
(Drosophila melanogaster)
SDHA [mitochondrial matrix]
(Gallus gallus)
SDHA [mitochondrial matrix]
(Mus musculus)
SDHA [mitochondrial matrix]
(Plasmodium falciparum)
SDHA [mitochondrial matrix]
(Rattus norvegicus)
SDHA [mitochondrial matrix]
(Saccharomyces cerevisiae)
SDHA [mitochondrial matrix]
(Schizosaccharomyces pombe)
SDHA [mitochondrial matrix]
(Sus scrofa)
SDHA [mitochondrial matrix]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001281261.1
,
NP_004159.2
ENSEMBL
ENSP00000264932
,
ENST00000510361
,
ENSP00000427703
,
ENST00000264932
OpenTargets
ENSG00000073578
HPA
ENSG00000073578-SDHA
PRO
P31040
Pharos - Targets
P31040
GlyGen
P31040
Orphanet
SDHA
HMDB Protein
HMDBP00150
PDB
8GS8
,
8DYE
,
8DYD
,
6VAX
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P21912 SDHB
2
SDHB [mitochondrial inner membrane]
(R-HSA-70985)
SDHB [mitochondrial matrix]
(R-HSA-9854983)
0.823
11
UniProt:Q9NX18 SDHAF2
1
SDHAF2 [mitochondrial matrix]
(R-HSA-9854689)
0.744
5
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.738
15
UniProt:P01889 HLA-B
8
class I MHC B7 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-983073)
class I MHC B7 [secretory granule membrane]
(R-HSA-6804794)
class I MHC B7 [plasma membrane]
(R-HSA-167756)
class I MHC B7 [Golgi membrane]
(R-HSA-983379)
class I MHC B7 [ER to Golgi transport vesicle membrane]
(R-HSA-983362)
class I MHC B7 [early endosome membrane]
(R-HSA-1236872)
class I MHC B7 [recycling endosome membrane]
(R-HSA-8863942)
class I MHC B7 [phagocytic vesicle membrane]
(R-HSA-1236753)
0.564
2
UniProt:Q86YH6 PDSS2
1
PDSS2 [mitochondrial matrix]
(R-HSA-2162264)
0.527
2
UniProt:P05141 SLC25A5
1
SLC25A5 [mitochondrial inner membrane]
(R-HSA-49743)
0.527
5
UniProt:Q5VUM1 SDHAF4
1
SDHAF4 [mitochondrial matrix]
(R-HSA-9854972)
0.527
3
UniProt:Q9P0J1 PDP1
1
PDP1 [mitochondrial matrix]
(R-HSA-204149)
0.527
2
UniProt:Q9NRP4 SDHAF3
1
SDHAF3 [mitochondrial matrix]
(R-HSA-9855015)
0.527
2
UniProt:Q9UPQ7 PZRN3
0.527
2
UniProt:Q9NTG7 SIRT3
2
SIRT3(?-399) [mitochondrial matrix]
(R-HSA-1605416)
SIRT3 [nucleoplasm]
(R-HSA-9622879)
0.527
2
UniProt:P26045 PTPN3
3
PTPN3 [cytosol]
(R-HSA-8867650)
p-S459 PTPN3 [cytosol]
(R-HSA-8868111)
PTPN3 [plasma membrane]
(R-HSA-5490317)
0.499
2
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.483
4
UniProt:A0A0F6B1Q8 A0A0F6B1Q8
0.462
2
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