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FH [mitochondrial matrix]
Stable Identifier
R-HSA-70980
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
fumarate hydratase, Fumarate hydratase, mitochondrial, Fumarase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
Pyruvate metabolism and Citric Acid (TCA) cycle (Homo sapiens)
Citric acid cycle (TCA cycle) (Homo sapiens)
(S)-Malate <=> Fumarate + H2O (Homo sapiens)
FH tetramer [mitochondrial matrix] (Homo sapiens)
FH [mitochondrial matrix] (Homo sapiens)
Fumarate + H2O <=> (S)-Malate (Homo sapiens)
FH tetramer [mitochondrial matrix] (Homo sapiens)
FH [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07954 FH
Gene Names
FH
Chain
initiator methionine:, transit peptide:1-44, chain:45-510
Reference Genes
BioGPS Gene:2271 FH
COSMIC (genes):FH FH
CTD Gene:2271 FH
dbSNP Gene:2271 FH
ENSEMBL:ENSG00000091483 FH
ENSEMBL:ENSG00000091483.8 FH
HGNC:3700 FH
KEGG Gene (Homo sapiens):2271 FH
Monarch:2271 FH
NCBI Gene:2271 FH
OMIM:136850 FH
UCSC:P07954 FH
Reference Transcript
RefSeq:NM_000143.3 FH
Other Identifiers
11744166_at
16701077
203032_PM_s_at
203032_s_at
203033_PM_x_at
203033_x_at
214170_PM_x_at
214170_x_at
2271
2463439
2463440
2463441
2463443
2463444
2463445
2463446
2463447
2463449
2463450
2463454
2463455
2463458
2463460
2463461
2852750
32546_at
7925480
A_23_P34733
GE59264
GO:0003824
GO:0004333
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005694
GO:0005737
GO:0005739
GO:0005759
GO:0005829
GO:0006091
GO:0006099
GO:0006106
GO:0006108
GO:0006281
GO:0006974
GO:0016829
GO:0043226
GO:0045239
GO:0048873
GO:0070062
GO:0120162
HMNXSV003025621
Hs.75653.0.A1_3p_a_at
Hs.75653.1.A1_3p_s_at
ILMN_1719392
PH_hs_0024542
TC01004025.hg
U59309_at
Participates
as a component of
FH tetramer [mitochondrial matrix] (Homo sapiens)
Inferred To
map1lc3c [mitochondrial matrix]
(Xenopus tropicalis)
FH [mitochondrial matrix]
(Bos taurus)
FH [mitochondrial matrix]
(Caenorhabditis elegans)
FH [mitochondrial matrix]
(Canis familiaris)
FH [mitochondrial matrix]
(Danio rerio)
FH [mitochondrial matrix]
(Dictyostelium discoideum)
FH [mitochondrial matrix]
(Gallus gallus)
FH [mitochondrial matrix]
(Mus musculus)
FH [mitochondrial matrix]
(Rattus norvegicus)
FH [mitochondrial matrix]
(Saccharomyces cerevisiae)
FH [mitochondrial matrix]
(Schizosaccharomyces pombe)
FH [mitochondrial matrix]
(Sus scrofa)
Fum1 [mitochondrial matrix]
(Drosophila melanogaster)
Homologues of FH [mitochondrial matrix]
(Sus scrofa)
Cross References
RefSeq
NP_000134.2
OpenTargets
ENSG00000091483
HPA
ENSG00000091483-FH
GeneCards
P07954
Ensembl
ENSG00000091483
,
ENSP00000355518
,
ENST00000366560
PRO
P07954
Pharos - Targets
P07954
Orphanet
16049
PDB
6VBE
,
5UPP
,
3E04
,
7LUB
,
6V8F
,
5D6B
,
6EBT
HMDB Protein
HMDBP00861
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NQT4 EXOSC5
2
EXOSC5 [cytosol]
(R-HSA-429889)
EXOSC5 [nucleoplasm]
(R-HSA-6791550)
0.556
3
UniProt:P21673 SAT1
1
SAT1 [cytosol]
(R-HSA-351236)
0.556
3
UniProt:P11309 PIM1
1
PIM1 [nucleoplasm]
(R-HSA-3215094)
0.556
3
UniProt:O15160 POLR1C
2
POLR1C [nucleoplasm]
(R-HSA-63498)
POLR1C [cytosol]
(R-HSA-1964454)
0.556
3
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