Reactome | GOPC [lysosomal membrane]

GOPC [lysosomal membrane]

Stable Identifier

R-HSA-5627281

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

lysosomal membrane

Synonyms

Golgi-associated PDZ and coiled-coil motif-containing protein, PIST, CAL, FIG

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases regulate CFTR trafficking (Homo sapiens)
        
        GOPC promotes translocation of CFTR to lysosomes (Homo sapiens)
        
        GOPC:CFTR [lysosomal membrane] (Homo sapiens)
        
        GOPC dimer [lysosomal membrane] (Homo sapiens)
        
        GOPC [lysosomal membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9HD26 GOPC

Gene Names

GOPC, CAL, FIG

Chain

initiator methionine:1, chain:2-462

Reference Genes

BioGPS Gene:57120 GOPC

COSMIC (genes):GOPC GOPC

CTD Gene:57120 GOPC

dbSNP Gene:57120 GOPC

ENSEMBL:ENSG00000047932 GOPC

HGNC:17643 GOPC

KEGG:hsa:57120 GOPC

Monarch:57120 GOPC

NCBI Gene:57120 GOPC

OMIM:606845 GOPC

UCSC:Q9HD26 GOPC

Reference Transcript

Participates

as a component of

GOPC dimer [lysosomal membrane] (Homo sapiens)

Other forms of this molecule

GOPC [Golgi-associated vesicle membrane]

GOPC [plasma membrane]

Inferred To

GOPC [lysosomal membrane] (Bos taurus)

GOPC [lysosomal membrane] (Canis familiaris)

GOPC [lysosomal membrane] (Gallus gallus)

GOPC [lysosomal membrane] (Sus scrofa)

Gopc [lysosomal membrane] (Mus musculus)

Gopc [lysosomal membrane] (Rattus norvegicus)

gopc [lysosomal membrane] (Danio rerio)

gopc [lysosomal membrane] (Xenopus tropicalis)

gopc-1 [lysosomal membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_065132.1, NP_001017408.1

OpenTargets

ENSG00000047932

ENSEMBL

ENST00000368498, ENST00000052569, ENSG00000047932, ENSP00000052569, ENSP00000357484

HPA

ENSG00000047932-GOPC

GeneCards

GOPC

PRO

Q9HD26

Pharos - Targets

Q9HD26

Orphanet

GOPC

GlyGen

Q9HD26

HMDB Protein

HMDBP08220

PDB

4K78, 7JZQ, 7JZO, 2DC2, 4K6Y, 4NMS, 4E34, 4JOR, 4JOJ, 4E35, 6OV7, 4Q6S, 4JOK, 4NMT, 4K72, 7JZP, 4NMP, 7JZR, 4K75, 4JOF, 5IC3, 5K4F, 4NMO, 4JOE, 4NMV, 4NMR, 4JOP, 4JOH, 2LOB, 4K76, 4JOG, 4NMQ, 4Q6H, 6XNJ, 6V84

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.767	10
UniProt:P04004 VTN	1	VTN [extracellular region] (R-HSA-215971)	0.666	4
UniProt:Q8IZQ8 MYOCD	1	MYOCD [nucleoplasm] (R-HSA-9735431)	0.666	4
UniProt:Q15418 RPS6KA1	7	p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm] (R-HSA-444292) p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol] (R-HSA-9619993) p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol] (R-HSA-9619871) p-T359,S363,T573-RPS6KA1 [cytosol] (R-HSA-9619957) RPS6KA1 [cytosol] (R-HSA-444256) p-4S,T359,T573-RPS6KA1 [nucleoplasm] (R-HSA-199829) RPS6KA1 [nucleoplasm] (R-HSA-199860)	0.611	4
UniProt:P60484 PTEN	20	K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379)	0.611	4
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.564	3
UniProt:Q6UWP7 LCLAT1	1	LCLAT1 [endoplasmic reticulum membrane] (R-HSA-1498783)	0.556	3
UniProt:P08631 HCK	2	HCK [cytosol] (R-HSA-167708) p-HCK [cytosol] (R-HSA-9676060)	0.556	3
UniProt:Q15746 MYLK	2	MYLK(1-1914) [cytosol] (R-HSA-445807) p-S1208,S1759-MYLK(1-1914) [cytosol] (R-HSA-5668975)	0.556	3
UniProt:Q99497 PARK7	7	PolyUb-Misfolded PARK7 [lysosomal lumen] (R-HSA-9659997) PolyUb-Misfolded PARK7 [cytosol] (R-HSA-9641128) Ub-Misfolded PARK7 [cytosol] (R-HSA-9641123) Misfolded PARK7 [cytosol] (R-HSA-9641100) PolyUb-Misfolded PARK7 [late endosome lumen] (R-HSA-9660005) PARK7 [nucleoplasm] (R-HSA-3900141) monoSUMO1-K130-PARK7 [nucleoplasm] (R-HSA-4085351)	0.556	3
UniProt:P35227 PCGF2	1	PCGF2 [nucleoplasm] (R-HSA-389115)	0.527	2
UniProt:P17275 JUNB	1	JUNB [nucleoplasm] (R-HSA-2186795)	0.527	3
UniProt:P29590 PML	5	PML [cytosol] (R-HSA-5624327) PML [nucleoplasm] (R-HSA-1031706) monoSUMO1-K65,160,490-PML [nucleoplasm] (R-HSA-3000440) polySUMO2-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000423) polySUMO3-K65,K160,K490-PML [nucleoplasm] (R-HSA-3000386)	0.527	2

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