Reactome | AHCYL1 [endoplasmic reticulum membrane]

AHCYL1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-5215973

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Putative adenosylhomocysteinase 2, SAHH2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O43865 AHCYL1

Gene Names

AHCYL1, DCAL, IRBIT, XPVKONA

Chain

initiator methionine:, chain:2-530

Reference Genes

BioGPS Gene:10768 AHCYL1

COSMIC (genes):AHCYL1 AHCYL1

CTD Gene:10768 AHCYL1

dbSNP Gene:10768 AHCYL1

ENSEMBL:ENSG00000168710 AHCYL1

HGNC:344 AHCYL1

KEGG:hsa:10768 AHCYL1

Monarch:10768 AHCYL1

NCBI Gene:10768 AHCYL1

OMIM:607826 AHCYL1

UCSC:O43865 AHCYL1

Reference Transcript

Other Identifiers

10768

11743426_s_at

11743427_at

11745746_a_at

11745747_x_at

11747331_a_at

11755901_x_at

16668439

200848_PM_at

200848_at

200849_PM_s_at

200849_s_at

200850_PM_s_at

200850_s_at

2351122

2351123

2351124

2351125

2351137

2351141

2351142

2351144

2351145

2351146

2351147

2351148

2351149

2351150

2351152

2351154

2351156

2351157

2351158

2351159

2351160

2351161

2351162

2351163

2351164

2351165

2351167

2351168

2351169

2351170

34727_at

34728_g_at

34792_at

41302_at

7903803

A_14_P100333

A_14_P139122

A_23_P368126

A_24_P11307

GE56213

GE81873

GO:0003723

GO:0003824

GO:0005515

GO:0005737

GO:0005783

GO:0005789

GO:0005829

GO:0005886

GO:0006611

GO:0006730

GO:0006790

GO:0006886

GO:0006913

GO:0006915

GO:0010765

GO:0012501

GO:0016324

GO:0016787

GO:0030234

GO:0031440

GO:0032412

GO:0033353

GO:0038166

GO:0042045

GO:0042802

GO:0043226

GO:0043231

GO:0044070

GO:0044233

GO:0051592

GO:0070062

GO:0098772

GO:1990456

HMNXSV003013425

Hs.4113.0.S2_3p_at

Hs.4113.0.S3_3p_a_at

ILMN_1770412

PH_hs_0000454

TC01000956.hg

g5729723_3p_a_at

Participates

as a component of

AHCYL1:NAD+ [endoplasmic reticulum membrane] (Homo sapiens)

Inferred To

Homologues of AHCYL1 [endoplasmic reticulum membrane] (Drosophila melanogaster)

AHCYL1 [endoplasmic reticulum membrane] (Bos taurus)

AHCYL1 [endoplasmic reticulum membrane] (Canis familiaris)

AHCYL1 [endoplasmic reticulum membrane] (Danio rerio)

AHCYL1 [endoplasmic reticulum membrane] (Drosophila melanogaster)

AHCYL1 [endoplasmic reticulum membrane] (Gallus gallus)

AHCYL1 [endoplasmic reticulum membrane] (Mus musculus)

AHCYL1 [endoplasmic reticulum membrane] (Plasmodium falciparum)

AHCYL1 [endoplasmic reticulum membrane] (Rattus norvegicus)

AHCYL1 [endoplasmic reticulum membrane] (Sus scrofa)

Cross References

RefSeq

NP_001229605.1, NP_001229604.1, NP_006612.2, NP_001229603.1, NP_001229602.1

OpenTargets

ENSG00000168710

ENSEMBL

ENSP00000377238, ENSP00000358814, ENST00000369799, ENST00000393614, ENST00000359172, ENSP00000352092

HPA

ENSG00000168710-AHCYL1

PRO

O43865

Pharos - Targets

O43865

GlyGen

O43865

PDB

3MTG

HMDB Protein

HMDBP00663

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P55040 GEM	1	GEM [plasma membrane] (R-HSA-9769962)	0.718	8
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.59	3
UniProt:P04608 tat	1	Tat (P04608) [nucleoplasm] (R-HIV-175856)	0.558	5
UniProt:O60437 PPL	2	PPL [cytosol] (R-HSA-6810850) PPL [cornified envelope] (R-HSA-8847709)	0.556	3
UniProt:P55957 BID	4	MYS-BID(62-195) [mitochondrial outer membrane] (R-HSA-114266) MYS-BID(62-195) [cytosol] (R-HSA-141373) BID(1-195) [cytosol] (R-HSA-50825) BID(62-195) [cytosol] (R-HSA-139953)	0.556	3
UniProt:Q8N2W9 PIAS4	2	PIAS4 [nucleoplasm] (R-HSA-2993789) monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415)	0.556	3
UniProt:Q9BZF9 UACA	1	UACA [cytosol] (R-HSA-6804636)	0.556	3
UniProt:O00233 PSMD9	1	PSMD9 [cytosol] (R-HSA-68810)	0.556	3
UniProt:Q9UG63 ABCF2	1	ABCF2 [plasma membrane] (R-HSA-5215945)	0.527	3
UniProt:P31152 MAPK4	4	MAPK4 [nucleoplasm] (R-HSA-5686975) MAPK4 [cytosol] (R-HSA-5686973) p-S186 MAPK4 [cytosol] (R-HSA-5687023) p-S186 MAPK4 [nucleoplasm] (R-HSA-5687022)	0.527	3
UniProt:Q14562 DHX8	1	DHX8 [nucleoplasm] (R-HSA-5688092)	0.527	3
UniProt:P05412 JUN	4	JUN [nucleoplasm] (R-HSA-450250) p-S63,S73-JUN [nucleoplasm] (R-HSA-450237) JUN [cytosol] (R-HSA-168194) p-S63,S73-JUN [cytosol] (R-HSA-8868682)	0.527	3
UniProt:P49674 CSNK1E	2	CSNK1E [cytosol] (R-HSA-205877) CSNK1E [nucleoplasm] (R-HSA-421306)	0.527	2
UniProt:P23526 AHCY	3	AHCY [cytosol] (R-HSA-174373) AHCY W112* [cytosol] (R-HSA-5579042) AHCY Y143C [cytosol] (R-HSA-5579098)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.519	7
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.483	2