CLIP1(1-1083)-p-6Y LTK(488-864) fusion [plasma membrane]

Stable Identifier
R-HSA-9842573
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
CAP-Gly domain-containing linker protein 1, CLIP1_HUMAN
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
34819663 The CLIP1-LTK fusion is an oncogenic driver in non-small-cell lung cancer

Izumi, H, Matsumoto, S, Liu, J, Tanaka, K, Mori, S, Hayashi, K, Kumagai, S, Shibata, Y, Hayashida, T, Watanabe, K, Fukuhara, T, Ikeda, T, Yoh, K, Kato, T, Nishino, K, Nakamura, A, Nakachi, I, Kuyama, S, Furuya, N, Sakakibara-Konishi, J, Okamoto, I, Taima, K, Ebi, N, Daga, H, Yamasaki, A, Kodani, M, Udagawa, H, Kirita, K, Zenke, Y, Nosaki, K, Sugiyama, E, Sakai, T, Nakai, T, Ishii, G, Niho, S, Ohtsu, A, Kobayashi, SS, Goto, K

Nature 2021
External Reference Information
External Reference
UniProt:P30622 CLIP1
Gene Names
CLIP1, CYLN1, RSN
Chain
chain:1-1438
Reference Genes
BioGPS Gene:6249 CLIP1
COSMIC - genes:CLIP1 CLIP1
CTD Gene:6249 CLIP1
dbSNP Gene:6249 CLIP1
ENSEMBL:ENSG00000130779 CLIP1
HGNC:10461 CLIP1
KEGG:hsa:6249 CLIP1
Monarch:6249 CLIP1
NCBI Gene:6249 CLIP1
OMIM:179838 CLIP1
UCSC:P30622 CLIP1
Reference Transcript
Participates
as a component of
Other forms of this molecule
CLIP1 [cytosol]
CLIP1(1-1083)-LTK(488-864) fusion [plasma membrane]
Modified Residues
Name
Insertion of residues 488 to 864 at 1084 from UniProt:P29376 LTK
Coordinate
1084
Name
O4'-phospho-L-tyrosine at 485
Coordinate
485
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 672
Coordinate
672
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 721
Coordinate
721
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 753
Coordinate
753
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 779
Coordinate
779
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 862
Coordinate
862
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name Identifier Synonyms
non-small cell lung carcinoma DOID:3908 Non-small cell lung cancer (disorder), NSCLC, NSCLC
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
Cross References
RefSeq
OpenTargets
ENSEMBL
Mondo
HPA
GeneCards
PRO
Pharos - Targets
Orphanet
GlyGen
PDB
Interactors (7)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q15691 MAPRE1  1 0.751 4
 UniProt:P68366 TUBA4A  9 0.618 3
 UniProt:Q14203 DCTN1  7 0.595 3
 UniProt:Q04864-2 REL      0.556 3
 UniProt:P0DTC6 6  4 0.547 2
 UniProt:Q9BQQ3 GORASP1  4 0.527 4
 UniProt:P13569 CFTR  17 0.483 4
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