Reactome | EIF3I [cytosol]

EIF3I [cytosol]

Stable Identifier

R-HSA-72536

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

eIF3-beta, eIF-3 beta, eIF3i, eIF3 p36, eukaryotic translation initiation factor 3 subunit 2, TRIP-1, TGF-beta receptor interacting protein 1, Eukaryotic translation initiation factor 3 subunit 2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13347 EIF3I

Gene Names

EIF3I, EIF3S2, TRIP1

Chain

chain:1-325

Reference Genes

BioGPS Gene:8668 EIF3I

COSMIC (genes):EIF3I EIF3I

CTD Gene:8668 EIF3I

dbSNP Gene:8668 EIF3I

ENSEMBL:ENSG00000084623 EIF3I

HGNC:3272 EIF3I

KEGG:hsa:8668 EIF3I

Monarch:8668 EIF3I

NCBI Gene:8668 EIF3I

OMIM:603911 EIF3I

UCSC:Q13347 EIF3I

Reference Transcript

RefSeq:NM_003757.3 EIF3I

Other Identifiers

11747337_x_at

1644_at

16662031

208756_3p_at

208756_PM_at

208756_at

2328801

2328802

2328804

2328806

2328809

2328810

2328811

2328812

2328813

2328814

2328815

2328816

2328817

2328818

2328819

2328820

2328821

2328822

2328823

2328824

2328825

2328826

2328834

3067803

32230_at

58907_at

7899737

8668

A_14_P114436

A_14_P129585

A_14_P200014

A_23_P85560

GE567023

GO:0001732

GO:0002183

GO:0003723

GO:0003743

GO:0005515

GO:0005737

GO:0005829

GO:0005852

GO:0006412

GO:0006413

GO:0016282

GO:0033290

GO:0043226

GO:0045182

GO:0045202

GO:0065003

GO:0070062

GO:0071541

HMNXSV003016467

HMNXSV003058292

ILMN_1671291

PH_hs_0011309

TC01000424.hg

U36764_at

g1036804_3p_x_at

Participates

as a component of

eIF3 subunits complex [cytosol] (Homo sapiens)

Inferred To

eIF3i [cytosol] (Drosophila melanogaster)

eif3I [cytosol] (Dictyostelium discoideum)

eif-3.I [cytosol] (Caenorhabditis elegans)

sum1 [cytosol] (Schizosaccharomyces pombe)

eif3i [cytosol] (Danio rerio)

eif3i [cytosol] (Xenopus tropicalis)

EIF3I [cytosol] (Bos taurus)

EIF3I [cytosol] (Canis familiaris)

EIF3I [cytosol] (Gallus gallus)

EIF3I [cytosol] (Plasmodium falciparum)

EIF3I [cytosol] (Sus scrofa)

Eif3i [cytosol] (Mus musculus)

Eif3i [cytosol] (Rattus norvegicus)

TIF34 [cytosol] (Saccharomyces cerevisiae)

Cross References

OpenTargets

ENSG00000084623

ENSEMBL

ENSP00000504034, ENST00000677202, ENSP00000502867, ENST00000677711, ENSP00000504061, ENSP00000503539, ENSG00000084623, ENST00000676801, ENST00000677760, ENST00000677701, ENSP00000503348

HPA

ENSG00000084623-EIF3I

GeneCards

EIF3I

PRO

Q13347

Pharos - Targets

Q13347

GlyGen

Q13347

PDB

7A09, 8OZ0, 8PJ1, 9BLN, 8PJ5, 8PJ3, 6ZMW, 8PJ2, 8PJ4, 6ZON, 8PJ6, 8XXN, 6ZVJ, 6YBT, 6ZP4

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	13
UniProt:P55212 CASP6	5	CASP6(194-293) [cytosol] (R-HSA-266128) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	8