Reactome | ARFGAP1 [cytosol]

ARFGAP1 [cytosol]

Stable Identifier

R-HSA-200464

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

GAP

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Unfolded Protein Response (UPR) (Homo sapiens)
    - IRE1alpha activates chaperones (Homo sapiens)
      - XBP1(S) activates chaperone genes (Homo sapiens)
        
        Expression of ARFGAP1 (GAP) (Homo sapiens)
        
        ARFGAP1 [cytosol] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPI-mediated anterograde transport (Homo sapiens)
        
        ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
        
        ARFGAP1,2,3 [cytosol] (Homo sapiens)
        
        ARFGAP1 [cytosol] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        ARFGAP1,2,3 [cytosol] (Homo sapiens)
        
        ARFGAP1 [cytosol] (Homo sapiens)
        
        ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
        
        ARFGAP1,2,3 [cytosol] (Homo sapiens)
        
        ARFGAP1 [cytosol] (Homo sapiens)
        
        RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        ARFGAP1,2,3 [cytosol] (Homo sapiens)
        
        ARFGAP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8N6T3 ARFGAP1

Gene Names

ARFGAP1, ARF1GAP

Chain

chain:1-406

Reference Genes

BioGPS Gene:55738 ARFGAP1

COSMIC (genes):ARFGAP1 ARFGAP1

CTD Gene:55738 ARFGAP1

dbSNP Gene:55738 ARFGAP1

ENSEMBL:ENSG00000101199 ARFGAP1

ENSEMBL:ENSG00000101199.13 ARFGAP1

HGNC:15852 ARFGAP1

KEGG Gene (Homo sapiens):55738 ARFGAP1

Monarch:55738 ARFGAP1

NCBI Gene:55738 ARFGAP1

OMIM:608377 ARFGAP1

UCSC:Q8N6T3 ARFGAP1

Reference Transcript

Other Identifiers

11745151_a_at

11745152_x_at

11747817_x_at

11751152_x_at

11754997_a_at

16915881

217888_PM_s_at

217888_s_at

234001_PM_s_at

234001_s_at

3893288

3893291

3893292

3893293

3893294

3893297

3893299

3893301

3893303

3893308

3893315

3893319

3893322

3893324

3893326

3893327

3893328

3893329

3893330

3893331

3893332

3893333

3893334

3893335

3893336

3893337

55738

57162_at

64332_at

8064042

A_23_P210379

A_24_P271296

GE61972

GO:0000139

GO:0005096

GO:0005515

GO:0005737

GO:0005794

GO:0005829

GO:0015031

GO:0016192

GO:0023052

GO:0030100

GO:0032012

GO:0043226

GO:0045202

GO:0046872

GO:0098772

HMNXSV003007937

Hs.25584.1.S1_3p_a_at

ILMN_1675709

ILMN_2406873

PH_hs_0002253

g8922651_3p_a_at

Participates

as a component of

ARFGAP1:ARF6:GTP [cytosol] (Homo sapiens)

as an output of

Expression of ARFGAP1 (GAP) (Homo sapiens)

as a member of

ARFGAP1,2,3 [cytosol] (Homo sapiens)

Inferred To

arfgap1 [cytosol] (Xenopus tropicalis)

Arfgap1 [cytosol] (Mus musculus)

Arfgap1 [cytosol] (Rattus norvegicus)

SPS18 [cytosol] (Saccharomyces cerevisiae)

ArfGAP1 [cytosol] (Drosophila melanogaster)

ARFGAP1 [cytosol] (Bos taurus)

ARFGAP1 [cytosol] (Caenorhabditis elegans)

ARFGAP1 [cytosol] (Canis familiaris)

ARFGAP1 [cytosol] (Danio rerio)

ARFGAP1 [cytosol] (Gallus gallus)

ARFGAP1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001268412.1, NP_060679.1, NP_783202.1, NP_001268411.1, NP_001268413.1

OpenTargets

ENSG00000101199

GeneCards

Q8N6T3

HPA

ENSG00000101199-ARFGAP1

Ensembl

ENSG00000101199, ENSP00000430500, ENSP00000314615, ENST00000370283, ENST00000519273, ENSP00000359298, ENST00000370275, ENST00000519604, ENSP00000443716, ENSP00000359306, ENST00000353546

PRO

Q8N6T3

Pharos - Targets

Q8N6T3

HMDB Protein

HMDBP08305

PDB

3DWD, 3O47

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:Q9BYR7 KRTAP3-2	1	KRTAP3-2 [cytosol] (R-HSA-6809857)	0.556	3
UniProt:Q6FG41 Q6FG41			0.556	3
UniProt:P36406 TRI23			0.556	3
UniProt:Q9BYQ4 KRTAP9-2	1	KRTAP9-2 [cytosol] (R-HSA-6809965)	0.556	3
UniProt:P60411 KRTAP10-9	1	KRTAP10-9 [cytosol] (R-HSA-6810277)	0.556	3
UniProt:P60520 GABARAPL2	3	GABARAPL2 [autophagosome membrane] (R-HSA-5683633) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [cytosol] (R-HSA-5671758)	0.556	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.554	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	7