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ARFGAP1 [cytosol]
Stable Identifier
R-HSA-200464
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
GAP
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
IRE1alpha activates chaperones (Homo sapiens)
XBP1(S) activates chaperone genes (Homo sapiens)
Expression of ARFGAP1 (GAP) (Homo sapiens)
ARFGAP1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
ARFGAP1,2,3 [cytosol] (Homo sapiens)
ARFGAP1 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARFGAP1,2,3 [cytosol] (Homo sapiens)
ARFGAP1 [cytosol] (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
ARFGAP1,2,3 [cytosol] (Homo sapiens)
ARFGAP1 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARFGAP1,2,3 [cytosol] (Homo sapiens)
ARFGAP1 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Clathrin-mediated endocytosis (Homo sapiens)
Recruitment of AP-2 complex and clathrin (Homo sapiens)
ARFGAP1:ARF6:GTP [cytosol] (Homo sapiens)
ARFGAP1 [cytosol] (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
ARFGAP1,2,3 [cytosol] (Homo sapiens)
ARFGAP1 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARFGAP1,2,3 [cytosol] (Homo sapiens)
ARFGAP1 [cytosol] (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
ARFGAP1,2,3 [cytosol] (Homo sapiens)
ARFGAP1 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
ARFGAP1,2,3 [cytosol] (Homo sapiens)
ARFGAP1 [cytosol] (Homo sapiens)
Intra-Golgi and retrograde Golgi-to-ER traffic (Homo sapiens)
Golgi-to-ER retrograde transport (Homo sapiens)
COPI-dependent Golgi-to-ER retrograde traffic (Homo sapiens)
ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi (Homo sapiens)
ARFGAP1,2,3 [cytosol] (Homo sapiens)
ARFGAP1 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
ARFGAP1,2,3 [cytosol] (Homo sapiens)
ARFGAP1 [cytosol] (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity at the Golgi membrane (Homo sapiens)
ARFGAP1,2,3 [cytosol] (Homo sapiens)
ARFGAP1 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:ARF:GTP:coatomer:p24 dimers:ARFGAPs:SEC22B:cargo [Golgi membrane] (Homo sapiens)
ARFGAP1,2,3 [cytosol] (Homo sapiens)
ARFGAP1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8N6T3 ARFGAP1
Gene Names
ARFGAP1, ARF1GAP
Chain
chain:1-406
Reference Genes
BioGPS Gene:55738 ARFGAP1
COSMIC (genes):ARFGAP1 ARFGAP3
CTD Gene:55738 ARFGAP1
dbSNP Gene:55738 ARFGAP1
ENSEMBL:ENSG00000101199 ARFGAP1
HGNC:15852 ARFGAP1
KEGG:hsa:55738 ARFGAP1
Monarch:55738 ARFGAP1
NCBI Gene:55738 ARFGAP1
OMIM:608377 ARFGAP1
UCSC:Q8N6T3 ARFGAP1
Reference Transcript
RefSeq:NM_001281483.1 ARFGAP1
RefSeq:NM_001281484.1 ARFGAP1
RefSeq:NM_001281482.1 ARFGAP1
RefSeq:NM_175609.2 ARFGAP1
RefSeq:NM_018209.3 ARFGAP1
Participates
as a component of
ARFGAP1:ARF6:GTP [cytosol] (Homo sapiens)
as an output of
Expression of ARFGAP1 (GAP) (Homo sapiens)
as a member of
ARFGAP1,2,3 [cytosol] (Homo sapiens)
Inferred To
arfgap1 [cytosol]
(Danio rerio)
arfgap1 [cytosol]
(Xenopus tropicalis)
Arfgap1 [cytosol]
(Mus musculus)
Arfgap1 [cytosol]
(Rattus norvegicus)
SPS18 [cytosol]
(Saccharomyces cerevisiae)
ArfGAP1 [cytosol]
(Drosophila melanogaster)
ARFGAP1 [cytosol]
(Bos taurus)
ARFGAP1 [cytosol]
(Caenorhabditis elegans)
ARFGAP1 [cytosol]
(Canis familiaris)
ARFGAP1 [cytosol]
(Gallus gallus)
ARFGAP1 [cytosol]
(Sus scrofa)
Cross References
ENSEMBL
ENST00000353546
,
ENST00000370283
,
ENSP00000359298
,
ENSG00000101199
,
ENSP00000443716
,
ENSP00000314615
,
ENSP00000430500
,
ENST00000519273
,
ENST00000370275
,
ENST00000519604
,
ENSP00000359306
OpenTargets
ENSG00000101199
GeneCards
ARFGAP1
HPA
ENSG00000101199-ARFGAP1
PRO
Q8N6T3
Pharos - Targets
Q8N6T3
GlyGen
Q8N6T3
HMDB Protein
HMDBP08305
PDB
3O47
,
3DWD
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.556
3
UniProt:Q9BYR7 KRTAP3-2
1
KRTAP3-2 [cytosol]
(R-HSA-6809857)
0.556
3
UniProt:P60520 GABARAPL2
3
GABARAPL2 [cytosol]
(R-HSA-5671758)
GABARAPL2(1-117) [cytosol]
(R-HSA-5682641)
GABARAPL2 [autophagosome membrane]
(R-HSA-5683633)
0.556
3
UniProt:P60411 KRTAP10-9
1
KRTAP10-9 [cytosol]
(R-HSA-6810277)
0.556
3
UniProt:Q9BYQ4 KRTAP9-2
1
KRTAP9-2 [cytosol]
(R-HSA-6809965)
0.556
3
UniProt:P36406 TRI23
0.556
3
UniProt:Q6FG41 Q6FG41
0.556
3
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.554
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
7
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