Reactome | UCHL1 [cytosol]

UCHL1 [cytosol]

Stable Identifier

R-HSA-5660679

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Ubiquitin carboxyl-terminal hydrolase isozyme L1, UCHL1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P09936 UCHL1

Gene Names

UCHL1

Chain

chain:1-220, propeptide:221-223

Reference Genes

BioGPS Gene:7345 UCHL1

COSMIC (genes):UCHL1 UCHL1

CTD Gene:7345 UCHL1

dbSNP Gene:7345 UCHL1

ENSEMBL:ENSG00000154277 UCHL1

ENSEMBL_homo_sapiens_GENE:ENSG00000154277.13 UCHL1

HGNC:12513 UCHL1

KEGG Gene (Homo sapiens):7345 UCHL1

Monarch:7345 UCHL1

NCBI Gene:7345 UCHL1

OMIM:191342 UCHL1

Reference Transcript

RefSeq:NM_004181.4 UCHL1

Other Identifiers

11754803_s_at

11757915_s_at

11758672_s_at

11758680_s_at

16966285

201387_PM_s_at

201387_s_at

2725032

2725033

2725034

2725035

2725038

2725041

2725042

2725043

2725044

2725047

2725048

2725052

2725053

2725054

2725055

2725056

36990_at

7345

8094778

A_23_P132956

GE81358

GO:0002176

GO:0002931

GO:0003824

GO:0004197

GO:0004843

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005789

GO:0005829

GO:0005886

GO:0006508

GO:0006511

GO:0006914

GO:0007018

GO:0007409

GO:0007412

GO:0007628

GO:0008233

GO:0008234

GO:0008242

GO:0016020

GO:0016241

GO:0016579

GO:0016787

GO:0019896

GO:0022414

GO:0023052

GO:0030154

GO:0030163

GO:0030424

GO:0031625

GO:0031694

GO:0036211

GO:0042755

GO:0043025

GO:0043130

GO:0043161

GO:0043226

GO:0043407

GO:0044306

GO:0048856

GO:0050877

GO:0050905

GO:0055001

GO:0071466

GO:0140096

GO:1904115

HMNXSV003019625

ILMN_1757387

PH_hs_0004392

TC04000253.hg

X04741_at

g4759283_3p_s_at

Participates

as a member of

UCHL1,UCHL3 [cytosol] (Homo sapiens)

Inferred To

UCH-L1 [cytosol] (Gallus gallus)

UCHL3 [cytosol] (Plasmodium falciparum)

ubh-2 [cytosol] (Caenorhabditis elegans)

uchl1 [cytosol] (Danio rerio)

uchl1 [cytosol] (Xenopus tropicalis)

ubh-3 [cytosol] (Caenorhabditis elegans)

Uchl1 [cytosol] (Mus musculus)

Uchl1 [cytosol] (Rattus norvegicus)

uch1 [cytosol] (Dictyostelium discoideum)

uch1 [cytosol] (Schizosaccharomyces pombe)

UCHL1 [cytosol] (Bos taurus)

UCHL1 [cytosol] (Canis familiaris)

UCHL1 [cytosol] (Sus scrofa)

Homologues of UCHL1 [cytosol] (Caenorhabditis elegans)

Uch [cytosol] (Drosophila melanogaster)

YUH1 [cytosol] (Saccharomyces cerevisiae)

ubh-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_004172.2

Guide to Pharmacology - Targets

2426

OpenTargets

ENSG00000154277

ZINC - Substances

UCHL1_HUMAN

ZINC target

P09936

PRO

P09936

PDB

3KW5, 3IFW, 8DY8, 2ETL, 4DM9, 3IRT, 4JKJ, 7ZM0, 3KVF, 8PW1, 8XI7, 2LEN, 8EDE

GeneCards

P09936

HPA

ENSG00000154277-UCHL1

Ensembl

ENSG00000154277, ENSP00000422542, ENST00000503431, ENSP00000284440, ENST00000284440

Pharos - Targets

P09936

ZINC - Predictions - Purchasable

UCHL1_HUMAN

Orphanet

15682

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.703	5
UniProt:Q14164 IKBKE	5	monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535) IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) K63polyUb-K30,K401-IKBKE [cytosol] (R-HSA-9730436) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521)	0.675	4
UniProt:Q9H1Y0 ATG5	3	ATG5 [phagocytic vesicle membrane] (R-HSA-5205636) GlyK130-ATG5 [cytosol] (R-HSA-5683582) ATG5 [cytosol] (R-HSA-936010)	0.675	4
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.675	4
UniProt:P83916 CBX1	1	CBX1 [nucleoplasm] (R-HSA-9653629)	0.666	4
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739) NEDD8(77-81) [cytosol] (R-HSA-6782654) NEDD8(1-81) [cytosol] (R-HSA-5690794) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8 [cytosol] (R-HSA-416969) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895)	0.666	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.635	3
UniProt:P11802 CDK4	3	CDK4 [cytosol] (R-HSA-68330) CDK4 [nucleoplasm] (R-HSA-113843) p-T172-CDK4 [nucleoplasm] (R-HSA-113830)	0.591	4
UniProt:P19474 TRIM21	1	TRIM21 [cytosol] (R-HSA-976051)	0.556	3
UniProt:O15392 BIRC5	3	ub-BIRC5 [cytosol] (R-HSA-8955933) BIRC5 [nucleoplasm] (R-HSA-4655344) BIRC5 [cytosol] (R-HSA-50851)	0.556	3
UniProt:P18847 ATF3	1	ATF3 [nucleoplasm] (R-HSA-535543)	0.556	3
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.556	3
UniProt:Q9BYZ2 LDHAL6B	1	LDHAL6B [mitochondrial matrix] (R-HSA-6807613)	0.556	3
UniProt:Q00535 CDK5	4	CDK5 [nucleoplasm] (R-HSA-8863586) p-Y15,S159-CDK5 [nucleoplasm] (R-HSA-6805249) CDK5 [cytosol] (R-HSA-180064) p-Y15-CDK5 [cytosol] (R-HSA-399809)	0.499	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	11
UniProt:P46527 CDKN1B	8	p-S10 CDKN1B [cytosol] (R-HSA-9632829) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-T157-CDKN1B [cytosol] (R-HSA-198629) CDKN1B [cytosol] (R-HSA-198622) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) CDKN1B [nucleoplasm] (R-HSA-182563)	0.463	2

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