Reactome | RPL28 [cytosol]

RPL28 [cytosol]

Stable Identifier

R-HSA-72444

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

60S ribosomal protein L28, P46779

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL28 [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL28 [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL28 [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL28 [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL28 [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL28 [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL28 [cytosol] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Influenza Infection (Homo sapiens)
      - Influenza Viral RNA Transcription and Replication (Homo sapiens)
        
        Viral mRNA Translation (Homo sapiens)
        
        Synthesis of PB1-F2 (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL28 [cytosol] (Homo sapiens)
        
        Viral Protein Synthesis (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL28 [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL28 [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL28 [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL28 [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL28 [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL28 [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL28 [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL28 [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL28 [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL28 [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL28 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P46779 RPL28

Gene Names

RPL28

Chain

initiator methionine:1, chain:2-137

Reference Genes

BioGPS Gene:6158 RPL28

COSMIC (genes):RPL28 RPL28

CTD Gene:6158 RPL28

dbSNP Gene:6158 RPL28

ENSEMBL:ENSG00000108107 RPL28

HGNC:10330 RPL28

KEGG:hsa:6158 RPL28

Monarch:6158 RPL28

NCBI Gene:6158 RPL28

OMIM:603638 RPL28

UCSC:P46779 RPL28

Reference Transcript

Other Identifiers

11716332_a_at

11716333_x_at

11739656_at

11740014_a_at

11740015_x_at

11741405_a_at

11753727_x_at

11758409_s_at

16653017

16865675

18671243

18671244

18671245

18671246

18671247

18671248

18671249

18671250

18671251

18671252

18671253

18678261

200003_PM_s_at

200003_s_at

213223_PM_at

213223_at

229938_PM_at

229938_at

2873582

31385_at

3842140

3842142

3842143

3842144

3842145

3842146

3842147

3842148

3842149

3842150

3842151

3842152

3842153

3842154

3842155

3842156

3842157

3842158

3842160

3842161

6158

7892688

7892906

7893486

7894057

7895137

7895510

7895677

7896292

8031483

80697_at

A_14_P117270

A_23_P208358

A_33_P3299309

A_33_P3299314

A_33_P3299319

GE80376

GE86035

GE88508

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0016020

GO:0022625

GO:0022626

GO:0030425

GO:0036464

GO:0043226

GO:0044297

GO:0045202

GO:0070062

GO:1990904

HMNXSV003041011

HMNXSV003042148

HMNXSV003050012

Hs.330570.0.S1_3p_at

ILMN_1673509

PH_hs_0017279

RNA95941|RNS_1023_93

TC19000896.hg

U14969_at

g4506626_3p_s_at

Participates

as a component of

Inferred To

Ghost homologue of RPL28 [cytosol] (Gallus gallus)

Ghost homologue of RPL28 [cytosol] (Saccharomyces cerevisiae)

Rpl28 [cytosol] (Mus musculus)

Rpl28 [cytosol] (Rattus norvegicus)

rpl28 [cytosol] (Danio rerio)

rpl28 [cytosol] (Dictyostelium discoideum)

rpl28 [cytosol] (Xenopus tropicalis)

RpL28 [cytosol] (Drosophila melanogaster)

rpl-28 [cytosol] (Caenorhabditis elegans)

rpl44 [cytosol] (Schizosaccharomyces pombe)

RPL28 [cytosol] (Bos taurus)

RPL28 [cytosol] (Canis familiaris)

RPL28 [cytosol] (Plasmodium falciparum)

RPL28 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_001129607.1, NP_001129606.1, NP_001129609.1, NP_001129608.1, NP_000982.2

OpenTargets

ENSG00000108107

ENSEMBL

ENSP00000342787, ENST00000560583, ENST00000559463, ENST00000558815, ENSP00000391665, ENST00000344063, ENSG00000108107, ENSP00000400596, ENSP00000452909, ENST00000431533, ENSP00000453319, ENSP00000453029, ENST00000428193

HPA

ENSG00000108107-RPL28

GeneCards

RPL28

PRO

P46779

Pharos - Targets

P46779

GlyGen

P46779

PDB

8FKW, 8G6J, 8XSX, 6Z6M, 6QZP, 8OJ5, 8IR3, 8FLA, 8QOI, 8IPD, 6W6L, 6ZME, 8JDM, 6OLG, 8FL2, 6XA1, 6LU8, 8FLF, 4V6X, 7BHP, 8QFD, 9G8M, 8FL9, 8IR1, 8FKX, 7XNY, 8IFE, 5LKS, 6IP5, 8INF, 8OJ8, 6Z6N, 7F5S, 8FLD, 8INE, 8FL7, 9GMO, 8FKS, 6ZMI, 9C3H, 8K2C, 6Y2L, 6LQM, 8FL4, 8JDL, 8Y0X, 6OLE, 8G61, 9FQ0, 8IPX, 6Y0G, 8IDT, 8YOP, 4UG0, 8IE3, 8FKU, 6IP6, 8IFD, 8XSZ, 8OHD, 8FLE, 8FKY, 6LSS, 6Z6L, 6ZMO, 6OM0, 8RL2, 8JDK, 8G60, 6ZM7, 8FLC, 6OLF, 5AJ0, 8UKB, 8A3D, 6Y57, 6OLZ, 8IDY, 8QYX, 8FL0, 6OM7, 8FL6, 7XNX, 8XSY, 8FKZ, 8FLB, 6LSR, 5T2C, 8FKQ, 7OW7, 8OJ0, 6OLI, 8G5Z, 6Y6X, 8FL3, 8INK, 8JDJ, 8G5Y, 8Y0W, 8IPY, 8GLP, 7QVP, 9FPZ, 8YOO, 6IP8

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.706	22
UniProt:P63244 RACK1	1	RACK1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:Q9NW13 RBM28	1	RBM28 [nucleoplasm] (R-HSA-6791192)	0.527	2
UniProt:Q8IY81 FTSJ3	1	FTSJ3 [nucleoplasm] (R-HSA-6791507)	0.527	3
UniProt:Q9Y3T9 NOC2L	1	NOC2L [nucleoplasm] (R-HSA-3222129)	0.527	2
UniProt:O43159 RRP8	1	RRP8 [nucleoplasm] (R-HSA-427524)	0.527	2
UniProt:O60832 DKC1	1	DKC1 [nucleoplasm] (R-HSA-163102)	0.527	2
UniProt:P61247 RPS3A	2	RPS3A [cytosol] (R-HSA-72373) RPS3A [nucleoplasm] (R-HSA-6791182)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.527	7
UniProt:Q15262 PTPRK	1	PTPRK [plasma membrane] (R-HSA-6785699)	0.527	2
UniProt:O96028 NSD2	2	WHSC1 [nucleoplasm] (R-HSA-1183215) p-S102-WHSC1 [nucleoplasm] (R-HSA-5682984)	0.527	2
UniProt:P05388 RPLP0	1	RPLP0 [cytosol] (R-HSA-72396)	0.527	3
UniProt:Q07020 RPL18	1	RPL18 [cytosol] (R-HSA-72420)	0.527	2
UniProt:P10636 MAPT	3	MAPT [cytosol] (R-HSA-201574) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT(422-758) [cytosol] (R-HSA-350642)	0.499	4
UniProt:P43146 DCC	4	p-Y1420-DCC [plasma membrane] (R-HSA-374552) DCC(1291-1447) [cytosol] (R-HSA-373629) DCC [plasma membrane] (R-HSA-197560) DCC(26-1290) [plasma membrane] (R-HSA-373627)	0.462	3

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