Reactome | PSMC4 [nucleoplasm]

PSMC4 [nucleoplasm]

Stable Identifier

R-HSA-174315

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

26S protease regulatory subunit 6B, MIP224, MB67 interacting protein, TAT-binding protein-7, TBP-7

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
        
        26S proteasome [nucleoplasm] (Homo sapiens)
        
        PSMC4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P43686 PSMC4

Gene Names

PSMC4, MIP224, TBP7

Chain

chain:1-418

Reference Genes

BioGPS Gene:5704 PSMC4

COSMIC (genes):PSMC4 PSMC4

CTD Gene:5704 PSMC4

dbSNP Gene:5704 PSMC4

ENSEMBL:ENSG00000013275 PSMC4

ENSEMBL_homo_sapiens_GENE:ENSG00000013275.8 PSMC4

ENSEMBL_homo_sapiens_GENE:ENSG00000281221.3 PSMC4

HGNC:9551 PSMC4

KEGG Gene (Homo sapiens):5704 PSMC4

Monarch:5704 PSMC4

NCBI Gene:5704 PSMC4

OMIM:602707 PSMC4

UCSC:P43686 PSMC4

Reference Transcript

Other Identifiers

11718881_a_at

11718882_x_at

16862145

201252_PM_at

201252_at

32848_at

3833292

3833293

3833294

3833295

3833296

3833297

3833298

3833300

3833301

3833304

3833306

3833308

3833310

3833311

3833312

5704

8028756

A_14_P113810

A_24_P91310

GE80314

GO:0000166

GO:0000502

GO:0001824

GO:0003824

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006508

GO:0008540

GO:0016020

GO:0016787

GO:0016887

GO:0022624

GO:0030163

GO:0036402

GO:0043161

GO:0043226

GO:0048856

GO:0140657

GO:1901800

HMNXSV003008946

HMNXSV003013766

ILMN_1687887

ILMN_2287888

ILMN_2395389

PH_hs_0012274

TC19000557.hg

g5729990_3p_s_at

Participates

as a component of

26S proteasome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMC4 [cytosol]

Inferred To

Rpt3 [nucleoplasm] (Drosophila melanogaster)

PSMC4 [nucleoplasm] (Bos taurus)

PSMC4 [nucleoplasm] (Caenorhabditis elegans)

PSMC4 [nucleoplasm] (Canis familiaris)

PSMC4 [nucleoplasm] (Dictyostelium discoideum)

PSMC4 [nucleoplasm] (Mus musculus)

PSMC4 [nucleoplasm] (Rattus norvegicus)

PSMC4 [nucleoplasm] (Sus scrofa)

psmc4 [nucleoplasm] (Danio rerio)

Ghost homologue of PSMC4 [nucleoplasm] (Gallus gallus)

Cross References

RefSeq

NP_006494.1, NP_694546.1

OpenTargets

ENSG00000013275

GeneCards

P43686

HPA

ENSG00000013275-PSMC4

Ensembl

ENSP00000157812, ENST00000157812, ENST00000630857, ENSP00000485851, ENSP00000413869, ENSG00000013275, ENSP00000487367, ENST00000629691, ENST00000455878, ENSG00000281221

PRO

P43686

Pharos - Targets

P43686

PDB

5VGZ, 5VFQ, 2DVW, 5VFP, 7W3I, 5GJQ, 7QXX, 7QY7, 5T0H, 7W3H, 5VHH, 5LN3, 5VHF, 5M32, 5T0C, 6MSE, 5VFT, 6MSD, 5VFS, 6MSB, 7QYB, 5VHN, 7QYA, 7W3K, 7W3A, 5VHM, 5GJR, 5T0J, 5VFR, 7W3J, 7W39, 5T0I, 6MSK, 5VHJ, 7W38, 6WJN, 5VHI, 6WJD, 5T0G, 7W37, 6MSJ, 6MSH, 7QXW, 7W3F, 7W3G, 5VHR, 5VHS, 6MSG, 7QXU, 8CVT, 5VFU, 5L4G, 7W3B, 5VHP, 7W3C, 5VHO, 7QXN, 5VHQ, 7QXP, 7W3M

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62333 PSMC6	2	PSMC6 [nucleoplasm] (R-HSA-174319) PSMC6 [cytosol] (R-HSA-68783)	0.825	9
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.802	7
UniProt:P36957 DLST	5	Lipo-K110-DLST [mitochondrial matrix] (R-HSA-69993) SuccinyllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853502) LipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9853485) DLST [mitochondrial matrix] (R-HSA-6792574) GlutaryllipoH2-K110-DLST [mitochondrial matrix] (R-HSA-9858581)	0.666	5
UniProt:O00487 PSMD14	5	PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [cytosol] (R-HSA-68722)	0.643	3
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.643	5
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	21
UniProt:P54578 USP14	1	USP14 [cytosol] (R-HSA-5689541)	0.564	2
UniProt:P27797 CALR	6	CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879)	0.556	3
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	4

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