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PSMC4 [nucleoplasm]
Stable Identifier
R-HSA-174315
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
26S protease regulatory subunit 6B, MIP224, MB67 interacting protein, TAT-binding protein-7, TBP-7
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1 phase and G1/S transition (Homo sapiens)
G1/S Transition (Homo sapiens)
Cyclin E associated events during G1/S transition (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC4 [nucleoplasm] (Homo sapiens)
Regulation of mitotic cell cycle (Homo sapiens)
APC/C-mediated degradation of cell cycle proteins (Homo sapiens)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Homo sapiens)
APC/C:Cdh1-mediated degradation of Skp2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC4 [nucleoplasm] (Homo sapiens)
Autodegradation of Cdh1 by Cdh1:APC/C (Homo sapiens)
Degradation of multiubiquitinated Cdh1 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC4 [nucleoplasm] (Homo sapiens)
S Phase (Homo sapiens)
Cyclin A:Cdk2-associated events at S phase entry (Homo sapiens)
SCF(Skp2)-mediated degradation of p27/p21 (Homo sapiens)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC4 [nucleoplasm] (Homo sapiens)
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
Nuclear events mediated by NFE2L2 (Homo sapiens)
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Homo sapiens)
Ub,pS335,S338,T NFE2L2 is degraded (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC4 [nucleoplasm] (Homo sapiens)
DNA Replication (Homo sapiens)
DNA Replication Pre-Initiation (Homo sapiens)
Assembly of the pre-replicative complex (Homo sapiens)
Ubiquitinated geminin is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC4 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
26S proteasome degrades PolyUb-RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC4 [nucleoplasm] (Homo sapiens)
Proteasome degrades polyubiquitinated RUNX2 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC4 [nucleoplasm] (Homo sapiens)
Transcriptional regulation by RUNX3 (Homo sapiens)
Regulation of RUNX3 expression and activity (Homo sapiens)
Polyubiquitinated RUNX3 is degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC4 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
GLI2,3 are degraded by the proteasome (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC4 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
Negative regulation of NOTCH4 signaling (Homo sapiens)
Proteasome degrades ubiquitinated NICD4 (Homo sapiens)
26S proteasome [nucleoplasm] (Homo sapiens)
PSMC4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P43686 PSMC4
Gene Names
PSMC4, MIP224, TBP7
Chain
chain:1-418
Reference Genes
BioGPS Gene:5704 PSMC4
COSMIC (genes):PSMC4 PSMC4
CTD Gene:5704 PSMC4
dbSNP Gene:5704 PSMC4
ENSEMBL:ENSG00000013275 PSMC4
ENSEMBL:ENSG00000281221 PSMC4
HGNC:9551 PSMC4
KEGG Gene (Homo sapiens):5704 PSMC4
Monarch:5704 PSMC4
NCBI Gene:5704 PSMC4
OMIM:602707 PSMC4
UCSC:P43686 PSMC4
Reference Transcript
RefSeq:NM_006503.3 PSMC4
RefSeq:NM_153001.2 PSMC4
Other Identifiers
0002350132
0006400204
11718881_a_at
11718882_x_at
16862145
201252_at
32848_at
3833292
3833293
3833294
3833295
3833296
3833297
3833298
3833300
3833301
3833304
3833306
3833308
3833310
3833311
3833312
5704
8028756
A_14_P113810
A_24_P91310
GE80314
GO:0000165
GO:0000166
GO:0000209
GO:0000278
GO:0000502
GO:0001824
GO:0002223
GO:0002376
GO:0002479
GO:0003674
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006508
GO:0006520
GO:0006521
GO:0006810
GO:0006950
GO:0007049
GO:0007165
GO:0007267
GO:0008150
GO:0008540
GO:0009056
GO:0009058
GO:0009790
GO:0010972
GO:0016020
GO:0016234
GO:0016579
GO:0016787
GO:0016887
GO:0022607
GO:0022624
GO:0030154
GO:0030163
GO:0031145
GO:0031146
GO:0031597
GO:0032991
GO:0033209
GO:0034641
GO:0034655
GO:0036388
GO:0036402
GO:0038061
GO:0038095
GO:0043161
GO:0043167
GO:0043226
GO:0043488
GO:0043687
GO:0044281
GO:0045202
GO:0045899
GO:0048856
GO:0050852
GO:0055085
GO:0060071
GO:0061418
GO:0065003
GO:0070498
GO:0090090
GO:0090263
GO:1901800
GO:1901990
GO:1902036
HMNXSV003008946
HMNXSV003013766
ILMN_1687887
ILMN_2287888
ILMN_2395389
PH_hs_0012274
TC19000557.hg
g5729990_3p_s_at
Participates
as a component of
26S proteasome [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PSMC4 [cytosol]
Inferred To
Rpt3 [nucleoplasm]
(Drosophila melanogaster)
Psmc4 [nucleoplasm]
(Mus musculus)
Psmc4 [nucleoplasm]
(Rattus norvegicus)
psmC4 [nucleoplasm]
(Dictyostelium discoideum)
rpt-3 [nucleoplasm]
(Caenorhabditis elegans)
PSMC4 [nucleoplasm]
(Canis familiaris)
PSMC4 [nucleoplasm]
(Sus scrofa)
psmc4 [nucleoplasm]
(Danio rerio)
rpt3 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_694546.1
,
NP_006494.1
OpenTargets
ENSG00000013275
HPA
ENSG00000013275-PSMC4
GeneCards
P43686
Ensembl
ENSP00000413869
,
ENST00000455878
,
ENST00000157812
,
ENSP00000485851
,
ENSP00000487367
,
ENSG00000281221
,
ENSG00000013275
,
ENSP00000157812
,
ENST00000630857
,
ENST00000629691
PRO
P43686
Pharos - Targets
P43686
GlyGen
P43686
PDB
5VHH
,
5T0C
,
6WJD
,
5VHS
,
6MSJ
,
5VHI
,
5VHF
,
6MSG
,
5VHR
,
5VFU
,
5M32
,
6MSH
,
5LN3
,
5GJQ
,
6WJN
,
5T0H
,
5VHM
,
5GJR
,
6MSK
,
5T0G
,
5VHJ
,
5VFQ
,
5T0J
,
6MSB
,
5VHO
,
5VGZ
,
5VFP
,
5T0I
,
2DVW
,
5VHN
,
5VHQ
,
6MSE
,
5L4G
,
5VFT
,
5VFR
,
6MSD
,
5VHP
,
5VFS
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [cytosol]
(R-HSA-1629778)
UCHL5 [nucleoplasm]
(R-HSA-5689584)
0.669
4
UniProt:P27797 CALR
6
CALR [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-985502)
CALR [endoplasmic reticulum lumen]
(R-HSA-195905)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863866)
CALR [phagocytic vesicle membrane]
(R-HSA-1236879)
CALR [extracellular region]
(R-HSA-2197641)
CALR [endocytic vesicle lumen]
(R-HSA-2239448)
0.556
3
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