Reactome | PSMC4 [nucleoplasm]

PSMC4 [nucleoplasm]

Stable Identifier

R-HSA-174315

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

26S protease regulatory subunit 6B, MIP224, MB67 interacting protein, TAT-binding protein-7, TBP-7

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P43686 PSMC4

Gene Names

PSMC4, MIP224, TBP7

Chain

chain:1-418

Reference Genes

BioGPS Gene:5704 PSMC4

COSMIC (genes):PSMC4 PSMC4

CTD Gene:5704 PSMC4

dbSNP Gene:5704 PSMC4

ENSEMBL:ENSG00000013275 PSMC4

ENSEMBL:ENSG00000281221 PSMC4

HGNC:9551 PSMC4

KEGG Gene (Homo sapiens):5704 PSMC4

Monarch:5704 PSMC4

NCBI Gene:5704 PSMC4

OMIM:602707 PSMC4

UCSC:P43686 PSMC4

Reference Transcript

Other Identifiers

0002350132

0006400204

11718881_a_at

11718882_x_at

16862145

201252_at

32848_at

3833292

3833293

3833294

3833295

3833296

3833297

3833298

3833300

3833301

3833304

3833306

3833308

3833310

3833311

3833312

5704

8028756

A_14_P113810

A_24_P91310

GE80314

GO:0000165

GO:0000166

GO:0000209

GO:0000278

GO:0000502

GO:0002223

GO:0002376

GO:0002479

GO:0003674

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006464

GO:0006508

GO:0006520

GO:0006521

GO:0006810

GO:0006950

GO:0007049

GO:0007165

GO:0007267

GO:0008150

GO:0008540

GO:0009056

GO:0009058

GO:0010972

GO:0016020

GO:0016234

GO:0016579

GO:0016787

GO:0016887

GO:0022607

GO:0022624

GO:0030154

GO:0030163

GO:0031145

GO:0031146

GO:0031597

GO:0032991

GO:0033209

GO:0034641

GO:0034655

GO:0036402

GO:0038061

GO:0038095

GO:0043161

GO:0043167

GO:0043226

GO:0043488

GO:0043687

GO:0044281

GO:0045202

GO:0045899

GO:0048856

GO:0050852

GO:0055085

GO:0060071

GO:0061418

GO:0065003

GO:0070498

GO:0090090

GO:0090263

GO:1901800

GO:1901990

GO:1902036

HMNXSV003008946

HMNXSV003013766

ILMN_1687887

ILMN_2287888

ILMN_2395389

PH_hs_0012274

TC19000557.hg

g5729990_3p_s_at

Participates

as a component of

26S proteasome [nucleoplasm] (Homo sapiens)

Other forms of this molecule

PSMC4 [cytosol]

Inferred To

Rpt3 [nucleoplasm] (Drosophila melanogaster)

Psmc4 [nucleoplasm] (Mus musculus)

Psmc4 [nucleoplasm] (Rattus norvegicus)

psmC4 [nucleoplasm] (Dictyostelium discoideum)

rpt-3 [nucleoplasm] (Caenorhabditis elegans)

PSMC4 [nucleoplasm] (Canis familiaris)

PSMC4 [nucleoplasm] (Sus scrofa)

psmc4 [nucleoplasm] (Danio rerio)

Cross References

RefSeq

NP_006494.1, NP_694546.1

OpenTargets

ENSG00000013275

HPA

ENSG00000013275-PSMC4

GeneCards

P43686

Ensembl

ENSP00000413869, ENSG00000281221, ENSG00000013275, ENSP00000485851, ENST00000455878, ENST00000630857, ENSP00000487367, ENST00000157812, ENSP00000157812, ENST00000629691

PRO

P43686

PDB

5GJQ, 5VFQ, 5LN3, 6MSB, 5VHI, 5VHH, 6WJD, 5VHP, 5M32, 6MSJ, 5VHF, 5T0I, 5VHO, 6MSH, 5VFU, 5T0J, 5VFP, 5VFT, 6MSG, 5VGZ, 5VHN, 6MSE, 5VHM, 5T0H, 5L4G, 5VHS, 6WJN, 5VHR, 5T0C, 5GJR, 5VFR, 2DVW, 5T0G, 5VHQ, 6MSK, 5VFS, 5VHJ, 6MSD

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [nucleoplasm] (R-HSA-5689584) UCHL5 [cytosol] (R-HSA-1629778)	0.669	4
UniProt:P27797 CALR	6	CALR [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448)	0.556	3