Reactome | EIF3M [cytosol]

EIF3M [cytosol]

Stable Identifier

R-HSA-377448

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

eIF3m

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q7L2H7 EIF3M

Gene Names

EIF3M, HFLB5, PCID1, GA17, PNAS-125

Chain

initiator methionine:, chain:2-374

Reference Genes

BioGPS Gene:10480 EIF3M

COSMIC (genes):EIF3M EIF3M

CTD Gene:10480 EIF3M

dbSNP Gene:10480 EIF3M

ENSEMBL:ENSG00000149100 EIF3M

ENSEMBL_homo_sapiens_GENE:ENSG00000149100.13 EIF3M

HGNC:24460 EIF3M

KEGG Gene (Homo sapiens):10480 EIF3M

Monarch:10480 EIF3M

NCBI Gene:10480 EIF3M

OMIM:609641 EIF3M

UCSC:Q7L2H7 EIF3M

Reference Transcript

Other Identifiers

10480

11729152_a_at

11752911_a_at

11752912_x_at

16723294

202231_PM_at

202231_at

202232_PM_s_at

202232_s_at

239848_PM_at

239848_at

3325681

3325682

3325690

3325691

3325693

3325695

3325697

3325701

3325704

3325707

3325710

3325714

3325720

3325721

3325723

3325724

3325725

35814_at

3982929

66366_at

73112_at

7939137

A_23_P150446

A_24_P138361

A_32_P68076

GE54591

GE549804

GE790701

GE86341

GO:0001732

GO:0002181

GO:0002183

GO:0003743

GO:0005515

GO:0005737

GO:0005829

GO:0005852

GO:0006412

GO:0006413

GO:0016282

GO:0031369

GO:0032991

GO:0033290

GO:0045182

GO:0065003

GO:0071541

HMNXSV003029910

Hs.120054.0.A1_3p_at

ILMN_2192693

ILMN_2192694

PH_hs_0022126

PH_hs_0036714

TC11000309.hg

TC11002622.hg

g5453653_3p_at

Participates

as a component of

eIF3 subunits complex [cytosol] (Homo sapiens)

Inferred To

Eif3m [cytosol] (Mus musculus)

Eif3m [cytosol] (Rattus norvegicus)

Ghost homologue of EIF3M [cytosol] (Saccharomyces cerevisiae)

eIF3m [cytosol] (Drosophila melanogaster)

eif3m [cytosol] (Danio rerio)

eif3m [cytosol] (Dictyostelium discoideum)

eif3m [cytosol] (Schizosaccharomyces pombe)

eif3m [cytosol] (Xenopus tropicalis)

Homologues of EIF3M [cytosol] (Bos taurus)

EIF3M [cytosol] (Bos taurus)

EIF3M [cytosol] (Canis familiaris)

EIF3M [cytosol] (Gallus gallus)

EIF3M [cytosol] (Plasmodium falciparum)

EIF3M [cytosol] (Sus scrofa)

cif-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_006351.2, NP_001294858.1

OpenTargets

ENSG00000149100

GeneCards

Q7L2H7

HPA

ENSG00000149100-EIF3M

Ensembl

ENSP00000436049, ENST00000531120, ENSP00000436787, ENSG00000149100, ENST00000524896

PRO

Q7L2H7

Pharos - Targets

Q7L2H7

PDB

3J8B, 7QP6, 3J8C, 6ZP4, 8OZ0, 6FEC, 6ZMW, 7A09, 6YBD, 6ZON, 8PPL, 7QP7, 6ZVJ

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00232 PSMD12	5	PSMD12 [secretory granule lumen] (R-HSA-6800934) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [cytosol] (R-HSA-68792)	0.643	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	4