Reactome | CDKAL1 [endoplasmic reticulum membrane]

CDKAL1 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-6786612

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Threonylcarbamoyladenosine tRNA methylthiotransferase ecNumber2.8.4.5/ecNumber, CDKAL_HUMAN

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External Reference Information

External Reference

UniProt:Q5VV42 CDKAL1

Gene Names

CDKAL1

Chain

chain:1-579

Reference Genes

BioGPS Gene:54901 CDKAL1

COSMIC (genes):CDKAL1 CDKAL1

CTD Gene:54901 CDKAL1

dbSNP Gene:54901 CDKAL1

ENSEMBL:ENSG00000145996 CDKAL1

HGNC:21050 CDKAL1

KEGG:hsa:54901 CDKAL1

Monarch:54901 CDKAL1

NCBI Gene:54901 CDKAL1

OMIM:611259 CDKAL1

UCSC:Q5VV42 CDKAL1

Reference Transcript

RefSeq:NM_017774.3 CDKAL1

Other Identifiers

11736202_a_at

11761247_at

17005253

214877_3p_at

214877_PM_at

214877_at

220039_PM_s_at

220039_s_at

2897639

2897640

2897641

2897642

2897643

2897648

2897661

2897675

2897676

2897678

2897681

2897688

2897703

2897716

2897717

2897731

2897750

2897756

2897757

2897769

2897770

2897771

2897772

2897773

2897774

2897775

2897776

54901

55579_at

8117140

A_14_P100219

A_23_P44781

A_23_P73058

A_32_P128310

GE82223

GO:0003824

GO:0005515

GO:0005783

GO:0005789

GO:0005791

GO:0006399

GO:0006400

GO:0008033

GO:0008150

GO:0016020

GO:0016740

GO:0035596

GO:0035598

GO:0035600

GO:0043226

GO:0046872

GO:0051536

GO:0051539

GO:0061712

GO:0140098

GO:1990145

HMNXSV003036438

HMNXSV003049141

Hs.306668.0.S1_3p_x_at

ILMN_1788022

PH_hs_0014420

TC06000132.hg

g8923317_3p_x_at

Participates

as a component of

CDKAL1:4Fe-4S [endoplasmic reticulum membrane] (Homo sapiens)

Cross References

ENSEMBL

ENSP00000481755, ENSP00000274695, ENST00000274695, ENST00000378610, ENSP00000367873, ENST00000613575, ENSG00000145996

OpenTargets

ENSG00000145996

IntEnz

2.8.4.5

GeneCards

CDKAL1

HPA

ENSG00000145996-CDKAL1

PRO

Q5VV42

Pharos - Targets

Q5VV42

GlyGen

Q5VV42

HMDB Protein

HMDBP09010

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54252 ATXN3	2	ATXN3 [nucleoplasm] (R-HSA-6783285) ATXN3 [cytosol] (R-HSA-5625607)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P06239 LCK	4	LCK [cytosol] (R-HSA-167609) p-Y394-LCK [cytosol] (R-HSA-202308) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [plasma membrane] (R-HSA-8857940)	0.556	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	9

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