Reactome | DDOST [endoplasmic reticulum membrane]

DDOST [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-264963

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

Ost48, AGER1

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        Late SARS-CoV-2 Infection Events (Homo sapiens)
        
        Translation of Structural Proteins (Homo sapiens)
        
        Maturation of spike protein (Homo sapiens)
        
        Spike protein gets N-glycosylated (Homo sapiens)
        
        OST complex [endoplasmic reticulum membrane] (Homo sapiens)
        
        DDOST [endoplasmic reticulum membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P39656 DDOST

Gene Names

DDOST, KIAA0115, OST48, OK/SW-cl.45

Chain

signal peptide:1-42, chain:43-456

Reference Genes

BioGPS Gene:1650 DDOST

COSMIC (genes):DDOST DDOST

CTD Gene:1650 DDOST

dbSNP Gene:1650 DDOST

ENSEMBL:ENSG00000244038 DDOST

ENSEMBL_homo_sapiens_GENE:ENSG00000244038.11 DDOST

HGNC:2728 DDOST

KEGG Gene (Homo sapiens):1650 DDOST

Monarch:1650 DDOST

NCBI Gene:1650 DDOST

OMIM:602202 DDOST

UCSC:P39656 DDOST

Reference Transcript

RefSeq:NM_005216.4 DDOST

Other Identifiers

11744057_x_at

11744058_a_at

11749195_x_at

1650

16682842

208674_3p_x_at

208674_PM_x_at

208674_x_at

208675_PM_s_at

208675_s_at

2400221

2400222

2400223

2400224

2400225

2400228

2400230

2400231

2400232

2400234

2400236

2400237

2400242

2400244

2400245

2400246

38791_at

49030_s_at

7913256

A_23_P149099

D29643_at

GE81479

GO:0002376

GO:0005515

GO:0005764

GO:0005773

GO:0005783

GO:0005789

GO:0005886

GO:0006486

GO:0006487

GO:0008047

GO:0008250

GO:0016020

GO:0018279

GO:0031410

GO:0031647

GO:0034097

GO:0035577

GO:0036211

GO:0042110

GO:0043226

GO:0043231

GO:0098772

GO:1901135

HMNXSV003010875

HMNXSV003045713

ILMN_1734231

PH_hs_0023611

PH_hs_0035771

TC01002316.hg

g473936_3p_a_at

Participates

as a component of

Other forms of this molecule

DDOST [azurophil granule membrane]

DDOST [plasma membrane]

Cross References

RefSeq

NP_005207.2

OpenTargets

ENSG00000244038

ZINC - Substances

OST48_HUMAN

ZINC target

P39656

PRO

P39656

PDB

8B6L, 6S7T, 6S7O

HPA

ENSG00000244038-DDOST

GeneCards

P39656

Ensembl

ENSG00000244038, ENST00000415136, ENSP00000399457

Pharos - Targets

P39656

Orphanet

21182

ZINC - Predictions - Purchasable

OST48_HUMAN

HMDB Protein

HMDBP01591

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.569	5
UniProt:Q14165 MLEC	3	MLEC [plasma membrane] (R-HSA-6806292) MLEC [specific granule membrane] (R-HSA-6799618) MLEC [endoplasmic reticulum membrane] (R-HSA-901082)	0.564	2
UniProt:Q86WV6 STING1	5	TMEM173 [plasma membrane] (R-HSA-6804815) TMEM173 [secretory granule membrane] (R-HSA-6804798) K63polyUb-STING [endoplasmic reticulum membrane] (R-HSA-3134805) K63polyUb-STING [cytoplasmic vesicle membrane] (R-HSA-3248021) STING [endoplasmic reticulum membrane] (R-HSA-1834940)	0.499	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	10