Reactome | EIF3E [cytosol]

EIF3E [cytosol]

Stable Identifier

R-HSA-72552

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

eIF3e, eIF-3 p48, Mammary tumor-associated protein INT-6, Viral integration site protein INT-6, eukaryotic translation initiation factor 3 subunit 6, Eukaryotic translation initiation factor 3 subunit 6

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P60228 EIF3E

Gene Names

EIF3E, EIF3S6, INT6

Chain

initiator methionine:1, chain:2-445

Reference Genes

BioGPS Gene:3646 EIF3E

COSMIC (genes):EIF3E EIF3E

CTD Gene:3646 EIF3E

dbSNP Gene:3646 EIF3E

ENSEMBL:ENSG00000104408 EIF3E

ENSEMBL:ENSG00000104408.11 EIF3E

HGNC:3277 EIF3E

KEGG Gene (Homo sapiens):3646 EIF3E

Monarch:3646 EIF3E

NCBI Gene:3646 EIF3E

OMIM:602210 EIF3E

UCSC:P60228 EIF3E

Reference Transcript

RefSeq:NM_001568.2 EIF3E

Other Identifiers

11727794_s_at

11727795_x_at

17080116

208697_PM_s_at

208697_s_at

2513325

2584751

2913496

3148605

3148606

3148607

3148610

3148613

3148618

3148619

3148620

3148628

3148630

3148634

3148635

3148638

3148639

3148640

3148644

3646

38681_at

8152323

GE79095

GO:0000184

GO:0000785

GO:0001732

GO:0002181

GO:0002183

GO:0003723

GO:0003743

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0005852

GO:0006412

GO:0006413

GO:0006446

GO:0014069

GO:0016020

GO:0016071

GO:0016282

GO:0016605

GO:0032991

GO:0033290

GO:0043226

GO:0045182

GO:0045296

GO:0045727

GO:0045947

GO:0065003

GO:0070062

GO:0071540

GO:1902416

PH_hs_0030043

U62962_at

g12653884_3p_s_at

Participates

as a component of

eIF3 subunits complex [cytosol] (Homo sapiens)

Inferred To

eIF3e [cytosol] (Drosophila melanogaster)

EIF3E [cytosol] (Bos taurus)

EIF3E [cytosol] (Canis familiaris)

EIF3E [cytosol] (Gallus gallus)

EIF3E [cytosol] (Plasmodium falciparum)

EIF3E [cytosol] (Sus scrofa)

Eif3e [cytosol] (Mus musculus)

Eif3e [cytosol] (Rattus norvegicus)

Ghost homologue of EIF3E [cytosol] (Saccharomyces cerevisiae)

eif3e [cytosol] (Xenopus tropicalis)

eif3ea [cytosol] (Danio rerio)

eif3E [cytosol] (Dictyostelium discoideum)

int6 [cytosol] (Schizosaccharomyces pombe)

eif-3.E [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001559.1

OpenTargets

ENSG00000104408

GeneCards

P60228

HPA

ENSG00000104408-EIF3E

Ensembl

ENSG00000104408, ENSP00000220849, ENST00000220849

PRO

P60228

Pharos - Targets

P60228

PDB

3J8B, 7A09, 6ZON, 6ZVJ, 3J8C, 6YBD, 7QP6, 6ZP4, 6FEC, 7QP7, 6ZMW

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99814 EPAS1	5	HN-EPAS1 [cytosol] (R-HSA-1234112) 2xHP-EPAS1 [cytosol] (R-HSA-1234149) 2xHP-EPAS1 [nucleoplasm] (R-HSA-1234151) EPAS1 [nucleoplasm] (R-HSA-452560) EPAS1 [cytosol] (R-HSA-1234119)	0.602	10
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.602	7
UniProt:P17252 PRKCA	8	PRKCA [cytosol] (R-HSA-58196) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) PRKCA [plasma membrane] (R-HSA-156469) p-T497-PRKCA [cytosol] (R-HSA-5218731) p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [nucleoplasm] (R-HSA-450530)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.547	2
UniProt:P04233 CD74	13	CD74(81-104) [lysosomal lumen] (R-HSA-2213220) CD74(81-104) [lysosomal membrane] (R-HSA-2130446) CD74(1-117) [lysosomal membrane] (R-HSA-2130632) CD74 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-1181241) CD74 [ER to Golgi transport vesicle membrane] (R-HSA-2130456) CD74 [Golgi membrane] (R-HSA-2214388) CD74 [trans-Golgi network membrane] (R-HSA-2130493) CD74 [transport vesicle membrane] (R-HSA-2130624) CD74 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130522) CD74 [endocytic vesicle membrane] (R-HSA-2130460) CD74(1-176) [lysosomal membrane] (R-HSA-2130602) CD74 [lysosomal membrane] (R-HSA-2130320) CD74 [plasma membrane] (R-HSA-2130666)	0.499	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	6

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