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CCT2 [azurophil granule lumen]
Stable Identifier
R-HSA-6799356
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
azurophil granule lumen
Synonyms
T-complex protein 1 subunit beta (TCP-1-beta)
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of azurophil granule lumen proteins (Homo sapiens)
Azurophil granule lumen proteins [azurophil granule lumen] (Homo sapiens)
CCT2 [azurophil granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P78371 CCT2
Gene Names
CCT2, 99D8.1, CCTB
Chain
initiator methionine:, chain:2-535
Reference Genes
BioGPS Gene:10576 CCT2
COSMIC (genes):CCT2 CCT2
CTD Gene:10576 CCT2
dbSNP Gene:10576 CCT2
ENSEMBL:ENSG00000166226 CCT2
ENSEMBL_homo_sapiens_GENE:ENSG00000166226.13 CCT2
HGNC:1615 CCT2
KEGG Gene (Homo sapiens):10576 CCT2
Monarch:10576 CCT2
NCBI Gene:10576 CCT2
OMIM:605139 CCT2
UCSC:P78371 CCT2
Reference Transcript
RefSeq:NM_001198842.1 CCT2
RefSeq:NM_006431.2 CCT2
Other Identifiers
10576
11715420_a_at
11715421_a_at
16753964
201946_PM_s_at
201946_s_at
201947_PM_s_at
201947_s_at
3421631
3421632
3421633
3421634
3421635
3421636
3421637
3421638
3421640
3421643
3421644
3421645
3421650
3421652
3421653
3421654
3421655
3421656
3421657
3421658
3421661
3421666
3421667
3421668
3421669
35759_at
7957052
A_23_P105392
GE61414
GO:0000166
GO:0002199
GO:0003824
GO:0005515
GO:0005524
GO:0005576
GO:0005615
GO:0005737
GO:0005764
GO:0005773
GO:0005829
GO:0005832
GO:0005856
GO:0005874
GO:0006457
GO:0007339
GO:0016787
GO:0016887
GO:0022414
GO:0031410
GO:0031625
GO:0032200
GO:0032212
GO:0035578
GO:0043226
GO:0044183
GO:0044297
GO:0050821
GO:0051082
GO:0051086
GO:0051131
GO:0051973
GO:0061077
GO:0065003
GO:0070062
GO:0090666
GO:0140657
GO:0140662
GO:1904851
GO:1904871
GO:1904874
HMNXSV003028752
Hs.6456.0.S1_3p_a_at
ILMN_1679382
PH_hs_0022906
PH_hs_0040227
TC12000616.hg
U91327_at
g5453602_3p_a_at
g5453602_3p_x_at
Participates
as a member of
Azurophil granule lumen proteins [azurophil granule lumen] (Homo sapiens)
Other forms of this molecule
CCT2 [extracellular region]
CCT2 [cytosol]
Inferred To
cct-2 [azurophil granule lumen]
(Caenorhabditis elegans)
cct2 [azurophil granule lumen]
(Dictyostelium discoideum)
cct2 [azurophil granule lumen]
(Schizosaccharomyces pombe)
cct2 [azurophil granule lumen]
(Xenopus tropicalis)
CCT2 [azurophil granule lumen]
(Bos taurus)
CCT2 [azurophil granule lumen]
(Canis familiaris)
CCT2 [azurophil granule lumen]
(Drosophila melanogaster)
CCT2 [azurophil granule lumen]
(Gallus gallus)
CCT2 [azurophil granule lumen]
(Plasmodium falciparum)
CCT2 [azurophil granule lumen]
(Saccharomyces cerevisiae)
CCT2 [azurophil granule lumen]
(Sus scrofa)
Cct2 [azurophil granule lumen]
(Mus musculus)
Cct2 [azurophil granule lumen]
(Rattus norvegicus)
Cross References
RefSeq
NP_006422.1
,
NP_001185771.1
OpenTargets
ENSG00000166226
GeneCards
P78371
HPA
ENSG00000166226-CCT2
Ensembl
ENSG00000166226
,
ENSP00000299300
,
ENST00000299300
,
ENST00000543146
,
ENSP00000445471
PRO
P78371
Pharos - Targets
P78371
PDB
6NRB
,
8SHN
,
7NVL
,
8SH9
,
8SG8
,
7TTN
,
7X7Y
,
6NRA
,
7TTT
,
8SHL
,
8SGQ
,
7TRG
,
8SGC
,
8SHG
,
8SFE
,
7LUP
,
8HKI
,
8SGL
,
7WZ3
,
8SHF
,
6NRD
,
8SHA
,
8I9U
,
8SHD
,
7X3J
,
6QB8
,
7NVO
,
7LUM
,
7X0S
,
8SHP
,
7X0V
,
6NRC
,
7WU7
,
8SHO
,
7X6Q
,
6NR9
,
8SFF
,
8SHE
,
6NR8
,
7X0A
,
7X3U
,
7NVM
,
8SHQ
,
7TUB
,
8SG9
,
8I1U
,
8IB8
,
8SHT
,
7NVN
Interactors (27)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.813
7
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.788
8
UniProt:P67775 PPP2CA
4
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
PPP2CA [nucleoplasm]
(R-HSA-165978)
PPP2CA [cytosol]
(R-HSA-165971)
0.758
5
UniProt:Q9BUR4 WRAP53
2
WRAP53 [nucleoplasm]
(R-HSA-418386)
Unfolded WRAP53 [cytosol]
(R-HSA-6813830)
0.69
6
UniProt:Q92466 DDB2
3
PolyUb-DDB2 [nucleoplasm]
(R-HSA-6783035)
DDB2 [nucleoplasm]
(R-HSA-53491)
PAR-DDB2 [nucleoplasm]
(R-HSA-5696654)
0.643
5
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.643
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
17
UniProt:Q8IWZ6 BBS7
1
BBS7 [cytosol]
(R-HSA-5617632)
0.597
3
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.569
10
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:Q8N0U8 VKORC1L1
1
VKORC1L1 [endoplasmic reticulum membrane]
(R-HSA-2980944)
0.556
3
UniProt:O14744 PRMT5
3
p-Y297,304,307-PRMT5 [nucleoplasm]
(R-HSA-5211300)
PRMT5 [nucleoplasm]
(R-HSA-5205609)
PRMT5 [cytosol]
(R-HSA-191876)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
6
UniProt:O15379 HDAC3
2
HDAC3 [nucleoplasm]
(R-HSA-442464)
Unfolded HDAC3 [cytosol]
(R-HSA-6813777)
0.527
4
UniProt:O43815 STRN
5
STRN [cytosol]
(R-HSA-9037081)
STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673902)
p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673908)
STRN(1-137)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9700485)
STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9700467)
0.527
2
UniProt:Q13371 PDCL
2
p-S18,S19,S20,S25-PDCL [cytosol]
(R-HSA-6814228)
PDCL [cytosol]
(R-HSA-6813727)
0.527
4
UniProt:P07437 TUBB
3
TUBB [cytosol]
(R-HSA-9020816)
TUBB [azurophil granule lumen]
(R-HSA-6799370)
TUBB [extracellular region]
(R-HSA-380317)
0.527
2
UniProt:Q00535 CDK5
4
CDK5 [nucleoplasm]
(R-HSA-8863586)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
CDK5 [cytosol]
(R-HSA-180064)
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
0.527
2
UniProt:Q676U5 ATG16L1
1
ATG16L1 [cytosol]
(R-HSA-5671734)
0.527
3
UniProt:O94953 KDM4B
2
K48PolyUb-KDM4B [nucleoplasm]
(R-HSA-5683074)
KDM4B [nucleoplasm]
(R-HSA-3214396)
0.527
3
UniProt:O43684 BUB3
1
BUB3 [cytosol]
(R-HSA-141416)
0.527
3
UniProt:O00628 PEX7
2
PEX7 [peroxisomal membrane]
(R-HSA-9033493)
PEX7 [cytosol]
(R-HSA-9033107)
0.527
3
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.527
6
UniProt:Q9BQA1 WDR77
3
WDR77 [nucleoplasm]
(R-HSA-5205610)
pT5-WDR77 [nucleoplasm]
(R-HSA-5205602)
WDR77 [cytosol]
(R-HSA-191823)
0.527
3
UniProt:Q7Z6Z6 PNPLA5
1
PNPLA5 [cytosol]
(R-HSA-8848346)
0.527
3
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.527
2
UniProt:Q9GZV5 WWTR1
3
p-S89-WWTR1 [cytosol]
(R-HSA-2028665)
WWTR1 [cytosol]
(R-HSA-1629773)
WWTR1 [nucleoplasm]
(R-HSA-1629775)
0.499
2
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