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SPAR [cytosol]
Stable Identifier
R-HSA-6794278
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SIPA1L1, Signal-induced proliferation-associated 1-like protein 1, SI1L1_HUMAN, Spine-Associated RapGAP (SPAR)
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Protein-protein interactions at synapses (Homo sapiens)
Neurexins and neuroligins (Homo sapiens)
NMDA receptor complex:DLG2,DLG3,DLG4 binds SPAR (Homo sapiens)
NMDA receptor complex:DLG2,DLG3,DLG4:SPAR [plasma membrane] (Homo sapiens)
SPAR [cytosol] (Homo sapiens)
SPAR [cytosol] (Homo sapiens)
NMDA receptor complex:DLG2,DLG3,DLG4:SPAR binds PDLIM5 (Homo sapiens)
NMDA receptor complex:DLG2,DLG3,DLG4:SPAR [plasma membrane] (Homo sapiens)
SPAR [cytosol] (Homo sapiens)
NMDA receptor complex:DLG2,DLG3,DLG4:SPAR:PDLIM5 [plasma membrane] (Homo sapiens)
NMDA receptor complex:DLG2,DLG3,DLG4:SPAR [plasma membrane] (Homo sapiens)
SPAR [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43166 SIPA1L1
Gene Names
SIPA1L1, E6TP1, KIAA0440
Chain
chain:1-1804
Reference Genes
BioGPS Gene:26037 SIPA1L1
COSMIC (genes):SIPA1L1 SIPA1L1
CTD Gene:26037 SIPA1L1
dbSNP Gene:26037 SIPA1L1
ENSEMBL:ENSG00000197555 SIPA1L1
HGNC:20284 SIPA1L1
KEGG:hsa:26037 SIPA1L1
Monarch:26037 SIPA1L1
NCBI Gene:26037 SIPA1L1
OMIM:617504 SIPA1L1
UCSC:O43166 SIPA1L1
Reference Transcript
RefSeq:XM_017021173.1 SIPA1L1
RefSeq:XM_017021161.1 SIPA1L1
RefSeq:XM_017021160.1 SIPA1L1
RefSeq:XM_017021180.1 SIPA1L1
RefSeq:XM_017021189.1 SIPA1L1
RefSeq:XM_017021188.1 SIPA1L1
RefSeq:XM_017021162.1 SIPA1L1
RefSeq:NM_001284245.1 SIPA1L1
RefSeq:XM_017021167.1 SIPA1L1
RefSeq:XM_017021169.1 SIPA1L1
RefSeq:XM_005267516.4 SIPA1L1
RefSeq:XM_017021186.1 SIPA1L1
RefSeq:NM_001284246.1 SIPA1L1
RefSeq:XM_017021168.1 SIPA1L1
RefSeq:NM_015556.2 SIPA1L1
RefSeq:XM_017021166.1 SIPA1L1
RefSeq:XM_017021165.1 SIPA1L1
RefSeq:XM_011536630.1 SIPA1L1
RefSeq:XM_017021164.1 SIPA1L1
RefSeq:XM_017021174.1 SIPA1L1
RefSeq:XM_017021175.1 SIPA1L1
RefSeq:XM_017021179.1 SIPA1L1
RefSeq:XM_017021176.1 SIPA1L1
RefSeq:XM_011536631.1 SIPA1L1
RefSeq:XM_017021171.1 SIPA1L1
RefSeq:XM_017021192.1 SIPA1L1
RefSeq:XM_017021190.1 SIPA1L1
RefSeq:XM_011536632.1 SIPA1L1
RefSeq:XM_017021187.1 SIPA1L1
RefSeq:XM_017021159.1 SIPA1L1
RefSeq:XM_017021193.1 SIPA1L1
RefSeq:XM_017021178.1 SIPA1L1
RefSeq:XM_017021177.1 SIPA1L1
RefSeq:XM_011536635.2 SIPA1L1
RefSeq:XM_017021172.1 SIPA1L1
RefSeq:XM_017021163.1 SIPA1L1
RefSeq:XM_017021191.1 SIPA1L1
RefSeq:XM_017021170.1 SIPA1L1
Other Identifiers
11754219_a_at
11763274_a_at
16786010
202254_PM_at
202254_at
202255_PM_s_at
202255_s_at
237032_3p_x_at
237032_PM_x_at
237032_x_at
26037
3542846
3542848
3542849
3542856
3542859
3542862
3542863
3542864
3542875
3542885
3542886
3542887
3542896
3542897
3542898
3542899
3542900
3542902
3542903
3542904
3542905
3542906
3542908
3542914
3542915
3542918
3542927
3542928
3542929
3542931
3542936
3542937
3542938
3542947
3542948
3542953
3542956
3542957
3542958
3542959
3542960
3542961
3542964
3542965
3542966
3542967
3542968
3542971
3542972
3542973
3542975
3542977
3542978
3542979
3542980
3542981
40805_at
54624_at
7975459
A_14_P102825
A_14_P106604
A_14_P131288
A_14_P131769
A_14_P139388
A_23_P76969
A_24_P219094
A_24_P344053
GE53187
GE782859
GE82015
GO:0003674
GO:0005096
GO:0005515
GO:0005737
GO:0005856
GO:0005886
GO:0007010
GO:0008150
GO:0014069
GO:0015629
GO:0030036
GO:0043005
GO:0043087
GO:0043197
GO:0043226
GO:0045202
GO:0046875
GO:0048013
GO:0048167
GO:0050770
GO:0051056
GO:0061001
GO:0090630
GO:0098772
HMNXSV003029248
HMNXSV003038821
Hs.150864.0.A1_3p_at
Hs.150864.0.A1_3p_x_at
Hs.172180.0.S2_3p_at
ILMN_2128162
PH_hs_0010312
PH_hs_0018191
PH_hs_0031993
TC14000433.hg
TC14001760.hg
g7662125_3p_a_at
p25913
Participates
as a component of
NMDA receptor complex:DLG2,DLG3,DLG4:SPAR [plasma membrane] (Homo sapiens)
as an input of
NMDA receptor complex:DLG2,DLG3,DLG4 binds SPAR (Homo sapiens)
Cross References
OpenTargets
ENSG00000197555
ENSEMBL
ENST00000555818
,
ENSP00000351352
,
ENSP00000370630
,
ENSP00000450832
,
ENST00000381232
,
ENST00000358550
HPA
ENSG00000197555-SIPA1L1
PRO
O43166
Pharos - Targets
O43166
GlyGen
O43166
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.756
6
UniProt:P03126 VE6
0.621
3
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.615
3
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.615
3
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.615
4
UniProt:P27348 YWHAQ
1
YWHAQ [cytosol]
(R-HSA-1445116)
0.615
3
UniProt:P78352 DLG4
3
DLG4 [plasma membrane]
(R-HSA-202135)
DLG4 [endocytic vesicle membrane]
(R-HSA-416847)
DLG4 [cytosol]
(R-HSA-6794267)
0.592
2
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.536
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
4
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