Reactome | p-T19,S20-MYL9 [cytosol]

p-T19,S20-MYL9 [cytosol]

Stable Identifier

R-HSA-390752

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-S20,T19-MYL9, Phosphorylated Myosin regulatory light polypeptide 9, p-MYL9

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - EPH-Ephrin signaling (Homo sapiens)
      - EPHA-mediated growth cone collapse (Homo sapiens)
        
        Activated ROCK phosphorylates MRLCs (Homo sapiens)
        
        p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Phosphorylated smooth muscle/non-muscle myosin 2 regulatory light chains [cytosol] (Homo sapiens)
        
        p-T19,S20-MYL9 [cytosol] (Homo sapiens)
    - Semaphorin interactions (Homo sapiens)
      - Sema4D in semaphorin signaling (Homo sapiens)
        
        Sema4D induced cell migration and growth-cone collapse (Homo sapiens)
        
        Myosin regulatory light chain phosphorylation by ROCK (Homo sapiens)
        
        p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Phosphorylated smooth muscle/non-muscle myosin 2 regulatory light chains [cytosol] (Homo sapiens)
        
        p-T19,S20-MYL9 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P24844 MYL9

Gene Names

MYL9, MLC2, MRLC1, MYRL2

Chain

initiator methionine:, chain:2-172

Reference Genes

BioGPS Gene:10398 MYL9

COSMIC (genes):MYL9 MYL9

CTD Gene:10398 MYL9

dbSNP Gene:10398 MYL9

ENSEMBL:ENSG00000101335 MYL9

HGNC:15754 MYL9

KEGG:hsa:10398 MYL9

Monarch:10398 MYL9

NCBI Gene:10398 MYL9

OMIM:609905 MYL9

UCSC:P24844 MYL9

Reference Transcript

Participates

as a member of

Phosphorylated smooth muscle/non-muscle myosin 2 regulatory light chains [cytosol] (Homo sapiens)

Other forms of this molecule

p-S20-MYL9 [cytosol]

p-T19-MYL9 [cytosol]

MYL9 [cytosol]

Modified Residues

Name

O-phospho-L-serine at 20

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 19

Coordinate

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

ENSEMBL

ENST00000346786, ENST00000279022, ENSG00000101335, ENSP00000217313, ENSP00000279022

OpenTargets

ENSG00000101335

GeneCards

MYL9

HPA

ENSG00000101335-MYL9

PRO

P24844

Pharos - Targets

P24844

HMDB Protein

HMDBP07826

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.547	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.527	16
UniProt:E9Q8Q6 CC141			0.463	2