Reactome | USP26 [nucleoplasm]

USP26 [nucleoplasm]

Stable Identifier

R-HSA-5696887

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Ubiquitin carboxyl-terminal hydrolase 26 ecNumber3.4.19.12/ecNumber, UBP26_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP12, USP26 deubiquitinate AR (Homo sapiens)
        
        USP12:WDR48:WDR20,USP26 [nucleoplasm] (Homo sapiens)
        
        USP26 [nucleoplasm] (Homo sapiens)
        
        USP12:WDR48:WDR20,USP26:AR [nucleoplasm] (Homo sapiens)
        
        USP12:WDR48:WDR20,USP26 [nucleoplasm] (Homo sapiens)
        
        USP26 [nucleoplasm] (Homo sapiens)
        
        USP12:WDR48:WDR20,USP26:PolyUb-AR [nucleoplasm] (Homo sapiens)
        
        USP12:WDR48:WDR20,USP26 [nucleoplasm] (Homo sapiens)
        
        USP26 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BXU7 USP26

Gene Names

USP26

Chain

chain:1-913

Reference Genes

BioGPS Gene:83844 USP26

COSMIC (genes):USP26 USP26

CTD Gene:83844 USP26

dbSNP Gene:83844 USP26

ENSEMBL:ENSG00000134588 USP26

ENSEMBL:ENSG00000134588.13 USP26

HGNC:13485 USP26

KEGG Gene (Homo sapiens):83844 USP26

Monarch:83844 USP26

NCBI Gene:83844 USP26

OMIM:300309 USP26

UCSC:Q9BXU7 USP26

Reference Transcript

Other Identifiers

11732981_at

17114256

224532_PM_at

224532_at

4022265

4022267

4022268

4022333

4022334

8175206

83844

ADDON002857.hg

A_23_P158118

GE517385

GO:0000082

GO:0000278

GO:0003824

GO:0004197

GO:0004843

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0006508

GO:0006511

GO:0008233

GO:0008234

GO:0016579

GO:0016787

GO:0030163

GO:0036211

GO:0043226

GO:0140096

HMNXSV003048079

ILMN_1744794

PH_hs_0016304

TC0X001373.hg

g13603868_3p_at

Participates

as a member of

USP12:WDR48:WDR20,USP26 [nucleoplasm] (Homo sapiens)

Inferred To

Homologues of USP26 [nucleoplasm] (Mus musculus)

Homologues of USP26 [nucleoplasm] (Rattus norvegicus)

usp12 [nucleoplasm] (Dictyostelium discoideum)

Usp29 [nucleoplasm] (Mus musculus)

Usp29 [nucleoplasm] (Rattus norvegicus)

USP26 [nucleoplasm] (Bos taurus)

USP26 [nucleoplasm] (Canis familiaris)

USP26 [nucleoplasm] (Gallus gallus)

USP26 [nucleoplasm] (Sus scrofa)

usp37 [nucleoplasm] (Danio rerio)

usp37 [nucleoplasm] (Xenopus tropicalis)

ubp9 [nucleoplasm] (Schizosaccharomyces pombe)

Usp26 [nucleoplasm] (Mus musculus)

Usp26 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_114113.1, XP_016885381.1

OpenTargets

ENSG00000134588

GeneCards

Q9BXU7

HPA

ENSG00000134588-USP26

Ensembl

ENSP00000423390, ENST00000511190, ENST00000370832, ENSP00000359869, ENSG00000134588

PRO

Q9BXU7

Pharos - Targets

Q9BXU7

HMDB Protein

HMDBP10128

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.508	4

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