Reactome | PSMD1 [azurophil granule lumen]

PSMD1 [azurophil granule lumen]

Stable Identifier

R-HSA-6798741

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

azurophil granule lumen

Synonyms

26S proteasome non-ATPase regulatory subunit 1, 26S proteasome regulatory subunit S1, 26S proteasome subunit p112, RPN2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q99460 PSMD1

Gene Names

PSMD1

Chain

chain:1-953

Reference Genes

BioGPS Gene:5707 PSMD1

COSMIC (genes):PSMD1 PSMD1

CTD Gene:5707 PSMD1

dbSNP Gene:5707 PSMD1

ENSEMBL:ENSG00000173692 PSMD1

HGNC:9554 PSMD1

KEGG:hsa:5707 PSMD1

Monarch:5707 PSMD1

NCBI Gene:5707 PSMD1

OMIM:617842 PSMD1

UCSC:Q99460 PSMD1

Reference Transcript

Participates

as a member of

Azurophil granule lumen proteins [azurophil granule lumen] (Homo sapiens)

Other forms of this molecule

PSMD1 [cytosol]

PSMD1 [nucleoplasm]

PSMD1 [extracellular region]

Inferred To

PSMD1 [azurophil granule lumen] (Bos taurus)

PSMD1 [azurophil granule lumen] (Canis familiaris)

PSMD1 [azurophil granule lumen] (Gallus gallus)

PSMD1 [azurophil granule lumen] (Plasmodium falciparum)

PSMD1 [azurophil granule lumen] (Sus scrofa)

Psmd1 [azurophil granule lumen] (Mus musculus)

Psmd1 [azurophil granule lumen] (Rattus norvegicus)

RPN2 [azurophil granule lumen] (Saccharomyces cerevisiae)

Rpn2 [azurophil granule lumen] (Drosophila melanogaster)

rpn-2 [azurophil granule lumen] (Caenorhabditis elegans)

rpn2 [azurophil granule lumen] (Schizosaccharomyces pombe)

psmD1 [azurophil granule lumen] (Dictyostelium discoideum)

psmd1 [azurophil granule lumen] (Danio rerio)

psmd1 [azurophil granule lumen] (Xenopus tropicalis)

Cross References

RefSeq

NP_001177966.1, NP_002798.2

OpenTargets

ENSG00000173692

ENSEMBL

ENSP00000503068, ENSP00000309474, ENSG00000173692, ENSP00000362738, ENST00000308696, ENST00000373635, ENST00000677230

HPA

ENSG00000173692-PSMD1

GeneCards

PSMD1

PRO

Q99460

Pharos - Targets

Q99460

GlyGen

Q99460

PDB

7W37, 5M32, 6WJN, 6MSG, 5T0G, 7QXW, 7W3M, 7W3K, 7QXN, 7QXP, 5T0J, 6MSE, 8CVT, 5GJQ, 5VHI, 7QYB, 5VHH, 5V1Z, 6OI4, 6WJD, 5L4K, 5VFS, 5VFP, 5VFQ, 6MSK, 7W3G, 7QXU, 5LN3, 6UYI, 6MSH, 7W3I, 7W38, 5GJR, 7W39, 5VGZ, 5T0H, 7W3F, 5T0I, 5VHS, 6MSD, 7W3C, 7QXX, 7QY7, 5T0C, 5V1Y, 7QYA, 6CO4, 5VFU, 5VFT, 6UYJ, 5VHF, 5VFR, 7W3H, 7W3J, 7W3B, 6MSJ, 7W3A, 6MSB

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.758	12
UniProt:Q16186 ADRM1	2	ADRM1 [cytosol] (R-HSA-5665939) ADRM1 [nucleoplasm] (R-HSA-9918361)	0.75	7
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.744	4
UniProt:O75832 PSMD10	1	PSMD10 [cytosol] (R-HSA-68788)	0.744	5
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.725	5
UniProt:P43686 PSMC4	2	PSMC4 [cytosol] (R-HSA-68777) PSMC4 [nucleoplasm] (R-HSA-174315)	0.669	4
UniProt:Q9UNM6 PSMD13	5	PSMD13 [cytosol] (R-HSA-68794) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413) PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [secretory granule lumen] (R-HSA-6800983)	0.669	4
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.669	4
UniProt:Q15008 PSMD6	5	PSMD6 [cytosol] (R-HSA-68804) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [secretory granule lumen] (R-HSA-6801036)	0.564	2
UniProt:Q9BRP4 PAAF1	1	PAAF1 [cytosol] (R-HSA-9907973)	0.564	2
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.553	2
UniProt:O00231 PSMD11	5	PSMD11 [cytosol] (R-HSA-68790) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [secretory granule lumen] (R-HSA-6800943)	0.528	2
UniProt:O00487 PSMD14	5	PSMD14 [cytosol] (R-HSA-68722) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [secretory granule lumen] (R-HSA-6800926)	0.527	2
UniProt:Q16401 PSMD5	1	PSMD5 [cytosol] (R-HSA-68802)	0.527	3
UniProt:O43242 PSMD3	5	PSMD3 [cytosol] (R-HSA-68798) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [secretory granule lumen] (R-HSA-6800873)	0.527	2
UniProt:Q13200 PSMD2	5	PSMD2 [cytosol] (R-HSA-68796) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [secretory granule lumen] (R-HSA-6800919)	0.527	2
UniProt:P25787 PSMA2	5	PSMA2 [cytosol] (R-HSA-68726) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [secretory granule lumen] (R-HSA-6803329)	0.527	2
UniProt:P51665 PSMD7	5	PSMD7 [cytosol] (R-HSA-68806) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [secretory granule lumen] (R-HSA-6801008)	0.527	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	4
UniProt:P35998 PSMC2	5	PSMC2 [cytosol] (R-HSA-68771) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [secretory granule lumen] (R-HSA-6800994)	0.527	2
UniProt:Q92731 ESR2	5	ESR2 [cytosol] (R-HSA-9020970) ESR2 [nucleoplasm] (R-HSA-446165) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) PalmS-ESR2 [cytosol] (R-HSA-9020979)	0.527	2
UniProt:O00232 PSMD12	5	PSMD12 [cytosol] (R-HSA-68792) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [secretory granule lumen] (R-HSA-6800934)	0.527	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	12