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ACTN4 [cytosol]
Stable Identifier
R-HSA-390558
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Alpha-actinin-4, ACTN4_HUMAN
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Nephrin family interactions (Homo sapiens)
Interaction of nephrin with adherens junction-associated proteins (Homo sapiens)
Nephrin dimer:adherins junction-associated proteins [plasma membrane] (Homo sapiens)
adherens junction-associated proteins [cytosol] (Homo sapiens)
Alpha-actinin [cytosol] (Homo sapiens)
ACTN4 [cytosol] (Homo sapiens)
adherens junction-associated proteins [cytosol] (Homo sapiens)
Alpha-actinin [cytosol] (Homo sapiens)
ACTN4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43707 ACTN4
Gene Names
ACTN4
Chain
chain:1-911
Reference Genes
BioGPS Gene:81 ACTN4
COSMIC (genes):ACTN4 ACTN4
CTD Gene:81 ACTN4
dbSNP Gene:81 ACTN4
ENSEMBL:ENSG00000130402 ACTN4
ENSEMBL:ENSG00000282844 ACTN4
ENSEMBL_homo_sapiens_GENE:ENSG00000130402.14 ACTN4
ENSEMBL_homo_sapiens_GENE:ENSG00000282844.2 ACTN4
HGNC:166 ACTN4
KEGG Gene (Homo sapiens):81 ACTN4
Monarch:81 ACTN4
NCBI Gene:81 ACTN4
OMIM:604638 ACTN4
UCSC:O43707 ACTN4
Reference Transcript
RefSeq:NM_004924.5 ACTN4
Other Identifiers
11715861_a_at
11747073_a_at
11747074_x_at
11747454_a_at
11753902_a_at
16861852
200601_PM_at
200601_at
2740728
2740731
2740759
2740761
3832644
3832645
3832646
3832683
3832684
3832685
3832686
3832688
3832689
3832690
3832693
3832694
3832695
3832697
3832699
3832702
3832703
3832706
3832707
3832708
3832711
3832714
3832719
3832720
3832721
3832722
3832723
3832725
41753_at
55075_at
57962_at
8028524
81
A_23_P101655
A_23_P315241
GE80030
GE865997
GO:0000977
GO:0001725
GO:0001882
GO:0003677
GO:0003713
GO:0003723
GO:0003779
GO:0005178
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005856
GO:0005886
GO:0005925
GO:0006351
GO:0006355
GO:0007010
GO:0007155
GO:0008092
GO:0012501
GO:0015031
GO:0015629
GO:0016922
GO:0023052
GO:0030018
GO:0030036
GO:0030050
GO:0030054
GO:0030154
GO:0030335
GO:0030374
GO:0030864
GO:0031093
GO:0031143
GO:0031410
GO:0031490
GO:0032417
GO:0032991
GO:0033209
GO:0035357
GO:0042803
GO:0042974
GO:0042981
GO:0042995
GO:0043226
GO:0044325
GO:0045944
GO:0046872
GO:0048384
GO:0048471
GO:0048856
GO:0048870
GO:0051015
GO:0055001
GO:0055085
GO:0070062
GO:0070161
GO:0140110
GO:1900025
GO:1901224
GO:1990904
HMNXSV003011844
ILMN_1725534
PH_hs_0025909
TC19000532.hg
g3157975_3p_at
Participates
as a member of
Alpha-actinin [cytosol] (Homo sapiens)
Other forms of this molecule
ACTN4 [platelet alpha granule lumen]
ACTN4 [extracellular region]
Cross References
RefSeq
NP_004915.2
OpenTargets
ENSG00000130402
GeneCards
O43707
HPA
ENSG00000130402-ACTN4
Ensembl
ENST00000252699
,
ENSP00000489220
,
ENST00000634692
,
ENSP00000252699
,
ENSG00000282844
,
ENST00000390009
,
ENST00000634960
,
ENSP00000439497
,
ENSP00000488962
,
ENSG00000130402
PRO
O43707
Pharos - Targets
O43707
Orphanet
15077
PDB
2R0O
,
6OA6
,
6O31
,
1WLX
,
1YDI
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.68
7
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
19
UniProt:P46940 IQGAP1
3
IQGAP1 [cytosol]
(R-HSA-5626371)
IQGAP1 [secretory granule membrane]
(R-HSA-6804803)
IQGAP1 [plasma membrane]
(R-HSA-381681)
0.602
4
UniProt:Q07157 TJP1
5
TJP1 [cell junction]
(R-HSA-8936023)
TJP1 (?-?) [plasma membrane]
(R-HSA-3209844)
TJP1 [plasma membrane]
(R-HSA-3209845)
TJP1 [Golgi-associated vesicle membrane]
(R-HSA-3209843)
TJP1 [cytosol]
(R-HSA-532659)
0.599
4
UniProt:O60294 LCMT2
1
LCMT2 [cytoplasm]
(R-HSA-6782869)
0.556
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P12830 CDH1
8
CDH1(732-882) [plasma membrane]
(R-HSA-3827997)
CDH1(155-700) [plasma membrane]
(R-HSA-2534244)
CDH1(701-882) [extracellular region]
(R-HSA-2534158)
Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8877002)
p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8876938)
CDH1(155-750) [plasma membrane]
(R-HSA-202940)
CDH1(751-882) [plasma membrane]
(R-HSA-202929)
CDH1(155-882) [plasma membrane]
(R-HSA-198003)
0.499
2
UniProt:P0DTC6 6
4
6 [nuclear envelope]
(R-COV-9727279)
6 [cytosol]
(R-COV-9708916)
6 [endoplasmic reticulum membrane]
(R-COV-9727295)
6 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9705293)
0.482
2
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