Reactome | ALDH1B1 [mitochondrial matrix]

ALDH1B1 [mitochondrial matrix]

Stable Identifier

R-HSA-5696097

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Aldehyde dehydrogenase X, mitochondrial ecNumber1.2.1.3/ecNumber, AL1B1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P30837 ALDH1B1

Gene Names

ALDH1B1, ALDH5, ALDHX

Chain

transit peptide:1-17, chain:18-517

Reference Genes

BioGPS Gene:219 ALDH1B1

COSMIC (genes):ALDH1B1 ALDH1B1

CTD Gene:219 ALDH1B1

dbSNP Gene:219 ALDH1B1

ENSEMBL:ENSG00000137124 ALDH1B1

HGNC:407 ALDH1B1

KEGG:hsa:219 ALDH1B1

Monarch:219 ALDH1B1

NCBI Gene:219 ALDH1B1

OMIM:100670 ALDH1B1

UCSC:P30837 ALDH1B1

Reference Transcript

Other Identifiers

11736073_a_at

11746588_a_at

17085082

209645_PM_s_at

209645_s_at

209646_3p_x_at

209646_PM_x_at

209646_x_at

219

3169332

3169333

3169334

3169335

3169336

3169337

3169338

3169339

3169340

3169341

3169342

38503_at

78124_at

8155327

A_14_P134247

A_14_P200254

A_23_P135294

A_24_P64233

GE58031

GO:0003824

GO:0004029

GO:0005654

GO:0005739

GO:0005759

GO:0005829

GO:0005975

GO:0006068

GO:0016491

GO:0016620

GO:0043226

GO:0043878

GO:0051287

HMNXSV003030820

Hs.169517.0.S1_3p_a_at

ILMN_1675398

ILMN_2150894

M63967_at

PH_hs_0025486

TC09000222.hg

Participates

as a member of

as a component of

ALDH1B1 tetramer [mitochondrial matrix] (Homo sapiens)

Inferred To

Aldh [mitochondrial matrix] (Drosophila melanogaster)

Homologues of ALDH1B1 [mitochondrial matrix] (Caenorhabditis elegans)

Homologues of ALDH1B1 [mitochondrial matrix] (Danio rerio)

Homologues of ALDH1B1 [mitochondrial matrix] (Drosophila melanogaster)

ALDH2 [mitochondrial matrix] (Dictyostelium discoideum)

ALDH2 [mitochondrial matrix] (Saccharomyces cerevisiae)

ALDH2 [mitochondrial matrix] (Schizosaccharomyces pombe)

aldh2.2 [mitochondrial matrix] (Danio rerio)

aldh2.1 [mitochondrial matrix] (Danio rerio)

Homologues of ALDH2 [mitochondrial matrix] (Dictyostelium discoideum)

Homologues of ALDH2 [mitochondrial matrix] (Saccharomyces cerevisiae)

hydA [mitochondrial matrix] (Dictyostelium discoideum)

ALDH1B1 [mitochondrial matrix] (Bos taurus)

ALDH1B1 [mitochondrial matrix] (Canis familiaris)

ALDH1B1 [mitochondrial matrix] (Mus musculus)

ALDH1B1 [mitochondrial matrix] (Rattus norvegicus)

ALDH1B1 [mitochondrial matrix] (Sus scrofa)

CT19744 [mitochondrial matrix] (Drosophila melanogaster)

alh-2 [mitochondrial matrix] (Caenorhabditis elegans)

aldh1b1 [mitochondrial matrix] (Xenopus tropicalis)

alh-1 [mitochondrial matrix] (Caenorhabditis elegans)

Cross References

ENSEMBL

ENST00000377698, ENSG00000137124, ENSP00000366927

OpenTargets

ENSG00000137124

GeneCards

ALDH1B1

HPA

ENSG00000137124-ALDH1B1

ZINC - Substances

AL1B1_HUMAN

ZINC target

P30837

PRO

P30837

Pharos - Targets

P30837

GlyGen

P30837

HMDB Protein

HMDBP00297

PDB

7MJD, 7MJC, 7RAD

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UMX1 SUFU	3	SUFU [ciliary base] (R-HSA-5610424) SUFU [cytosol] (R-HSA-445455) SUFU [ciliary tip] (R-HSA-5610426)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	8

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