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GFPT1 [cytosol]
Stable Identifier
R-HSA-532216
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Glucosamine--fructose-6-phosphate aminotransferase (isomerizing) 1
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
IRE1alpha activates chaperones (Homo sapiens)
XBP1(S) activates chaperone genes (Homo sapiens)
Expression of GFPT1 (Homo sapiens)
GFPT1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein (Homo sapiens)
Synthesis of substrates in N-glycan biosythesis (Homo sapiens)
Synthesis of UDP-N-acetyl-glucosamine (Homo sapiens)
GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P (Homo sapiens)
GFPT1,2 [cytosol] (Homo sapiens)
GFPT1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q06210 GFPT1
Gene Names
GFPT1, GFAT, GFPT
Chain
initiator methionine:, chain:2-699
Reference Genes
BioGPS Gene:2673 GFPT1
COSMIC (genes):GFPT1 GFPT1
CTD Gene:2673 GFPT1
dbSNP Gene:2673 GFPT1
ENSEMBL:ENSG00000198380 GFPT1
ENSEMBL_homo_sapiens_GENE:ENSG00000198380.13 GFPT1
HGNC:4241 GFPT1
KEGG Gene (Homo sapiens):2673 GFPT1
Monarch:2673 GFPT1
NCBI Gene:2673 GFPT1
OMIM:138292 GFPT1
UCSC:Q06210 GFPT1
Reference Transcript
RefSeq:NM_001244710.1 GFPT1
RefSeq:NM_002056.3 GFPT1
Other Identifiers
11720221_at
11720222_at
11720223_at
11757975_s_at
11758456_s_at
16898578
202721_PM_s_at
202721_s_at
202722_PM_s_at
202722_s_at
226886_PM_at
226886_at
227027_PM_at
227027_at
2558063
2558064
2558065
2558066
2558067
2558068
2558069
2558070
2558071
2558072
2558073
2558074
2558075
2558077
2558078
2558082
2558085
2558086
2558087
2558088
2558089
2558092
2558094
2558095
2558097
2558099
2558102
2558109
2558110
2673
32626_at
3284171
61346_at
8052762
90240_at
A_23_P345887
A_23_P44083
A_33_P3243153
GE54887
GE58132
GO:0003824
GO:0004360
GO:0005576
GO:0005615
GO:0005829
GO:0006002
GO:0006047
GO:0006048
GO:0006091
GO:0006112
GO:0006486
GO:0006487
GO:0006520
GO:0006541
GO:0008483
GO:0016740
GO:0032922
GO:0036211
GO:0043226
GO:0048511
GO:0055086
GO:0070062
GO:0097367
GO:1901135
GO:1901137
HMNXSV003038583
Hs.13396.0.A1_3p_at
Hs.1674.0.S1_3p_a_at
Hs.24723.0.A1_3p_at
ILMN_2220184
ILMN_2220187
M90516_at
PH_hs_0000227
PH_hs_0039878
TC02001948.hg
g4503980_3p_a_at
Participates
as an output of
Expression of GFPT1 (Homo sapiens)
as a member of
GFPT1,2 [cytosol] (Homo sapiens)
Other forms of this molecule
GFPT1 T15A [cytosol]
GFPT1 T147Qfs*61 [cytosol]
GFPT1 R111C [cytosol]
GFPT1 D348Y [cytosol]
GFPT1 W240* [cytosol]
Inferred To
GFPT1 [cytosol]
(Bos taurus)
GFPT1 [cytosol]
(Canis familiaris)
GFPT1 [cytosol]
(Dictyostelium discoideum)
GFPT1 [cytosol]
(Gallus gallus)
GFPT1 [cytosol]
(Mus musculus)
GFPT1 [cytosol]
(Plasmodium falciparum)
GFPT1 [cytosol]
(Rattus norvegicus)
GFPT1 [cytosol]
(Schizosaccharomyces pombe)
GFPT1 [cytosol]
(Sus scrofa)
GFA1 [cytosol]
(Saccharomyces cerevisiae)
Gfat2 [cytosol]
(Drosophila melanogaster)
gfpt1 [cytosol]
(Danio rerio)
gfpt1 [cytosol]
(Xenopus tropicalis)
gfat-1 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001231639.1
,
NP_002047.2
OpenTargets
ENSG00000198380
ZINC - Substances
GFPT1_HUMAN
ZINC - Biogenic
GFPT1_HUMAN
ZINC target
Q06210
PRO
Q06210
PDB
6R4F
,
6SVO
,
2ZJ4
,
7NDL
,
6ZMK
,
6SVM
,
6R4E
,
2V4M
,
6SVQ
,
6R4H
,
6R4G
,
6SVP
,
6R4I
,
6ZMJ
,
6R4J
,
2ZJ3
ZINC - Metabolites
GFPT1_HUMAN
IntEnz
2.6.1.16
HPA
ENSG00000198380-GFPT1
GeneCards
Q06210
Ensembl
ENST00000357308
,
ENST00000361060
,
ENSP00000349860
,
ENSG00000198380
,
ENSP00000354347
Pharos - Targets
Q06210
ZINC - Predictions - Purchasable
GFPT1_HUMAN
Orphanet
19829
HMDB Protein
HMDBP00216
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O94808 GFPT2
1
GFPT2 [cytosol]
(R-HSA-532208)
0.499
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
11
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