Reactome | PGK1 [cytosol]

PGK1 [cytosol]

Stable Identifier

R-HSA-70483

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphoglycerate kinase 1 , Primer recognition protein 2, PRP 2

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P00558 PGK1

Gene Names

PGK1, PGKA, MIG10, OK/SW-cl.110

Chain

initiator methionine:1, chain:2-417

Reference Genes

BioGPS Gene:5230 PGK1

COSMIC (genes):PGK1 PGK1

CTD Gene:5230 PGK1

dbSNP Gene:5230 PGK1

ENSEMBL:ENSG00000102144 PGK1

HGNC:8896 PGK1

KEGG Gene (Homo sapiens):5230 PGK1

Monarch:5230 PGK1

NCBI Gene:5230 PGK1

OMIM:311800 PGK1

Reference Transcript

RefSeq:NM_000291.3 PGK1

Other Identifiers

0007000184

0101980377

11733871_a_at

11733872_x_at

11733873_a_at

11746818_s_at

11752939_x_at

11753085_a_at

11753086_x_at

11756213_x_at

11756297_x_at

1558365_at

17105047

200737_at

200738_s_at

217356_s_at

227068_at

228483_s_at

31488_s_at

37677_at

3821775

3821782

3982386

3982387

3982388

3982389

3982424

3982469

3982470

3982471

3982472

3982473

3982475

3982476

3982477

3982481

3982483

3982484

3982486

3982488

3982489

3982490

3982491

3982492

4011291

4056085

4056095

4056097

4056098

4056099

4056100

4056101

4056102

4056104

4056105

4056106

4056107

4056108

4056109

4056111

4056113

4056145

5230

8168500

91445_at

A_23_P125829

A_24_P254532

A_32_P14212

A_32_P627

GE59614

GE86530

GO:0000166

GO:0003674

GO:0004618

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005829

GO:0005975

GO:0006091

GO:0006094

GO:0006096

GO:0006950

GO:0008150

GO:0009056

GO:0009058

GO:0016020

GO:0016301

GO:0016310

GO:0016491

GO:0016525

GO:0016740

GO:0030154

GO:0030855

GO:0031639

GO:0034641

GO:0043167

GO:0043226

GO:0043531

GO:0044003

GO:0044281

GO:0044403

GO:0045121

GO:0047134

GO:0048646

GO:0048856

GO:0051604

GO:0061621

GO:0070062

GO:0071456

HMNXSV003027961

Hs.169313.0.S1_3p_s_at

Hs.171723.1.A1_3p_at

Hs.78771.1.S1_3p_at

Hs2.288933.1.S1_3p_at

ILMN_1755749

ILMN_2216852

PH_hs_0004542

TC0X000425.hg

V00572_at

g4505762_3p_a_at

Participates

as a component of

as an input of

esxA binds PGK1 (Homo sapiens)

Inferred To

Pgk [cytosol] (Drosophila melanogaster)

pgk1 [cytosol] (Danio rerio)

pgk1 [cytosol] (Schizosaccharomyces pombe)

pgk1 [cytosol] (Xenopus tropicalis)

PGK1 [cytosol] (Canis familiaris)

PGK1 [cytosol] (Saccharomyces cerevisiae)

PGK1 [cytosol] (Sus scrofa)

pgk-1 [cytosol] (Caenorhabditis elegans)

pgkA [cytosol] (Dictyostelium discoideum)

PGK [cytosol] (Plasmodium falciparum)

PGK2 [cytosol] (Gallus gallus)

Pgk1 [cytosol] (Mus musculus)

Pgk1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_000282.1

OpenTargets

ENSG00000102144

IntEnz

2.7.2.3

HPA

ENSG00000102144-PGK1

GeneCards

P00558

Ensembl

ENSG00000102144, ENST00000373316, ENSP00000362413, ENSP00000496140, ENST00000644362

PRO

P00558

Pharos - Targets

P00558

Orphanet

16650

GlyGen

P00558

HMDB Protein

HMDBP01528

PDB

2Y3I, 5O7D, 2WZC, 2WZB, 5MXM, 5M3U, 3C3C, 3ZOZ, 2XE7, 2X14, 2X13, 2XE6, 2ZGV, 2WZD, 2X15, 5M6Z, 2YBE, 2XE8, 3C39, 4AXX, 5NP8, 3C3B, 5M1R, 4O33, 3C3A

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P12004 PCNA	5	K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) SUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) PCNA [nucleoplasm] (R-HSA-68439)	0.573	2
UniProt:Q9NRI5 DISC1			0.553	2
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.544	2
UniProt:O15379 HDAC3	2	Unfolded HDAC3 [cytosol] (R-HSA-6813777) HDAC3 [nucleoplasm] (R-HSA-442464)	0.524	2