Reactome | PGK1 [cytosol]

PGK1 [cytosol]

Stable Identifier

R-HSA-70483

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphoglycerate kinase 1 , Primer recognition protein 2, PRP 2

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Bacterial Infection Pathways (Homo sapiens)
    - Infection with Mycobacterium tuberculosis (Homo sapiens)
      - Response of Mtb to phagocytosis (Homo sapiens)
        
        Manipulation of host energy metabolism (Homo sapiens)
        
        EsxA binds PGK1 (Homo sapiens)
        
        EsxA:PGK1 [cytosol] (Homo sapiens)
        
        PGK1 [cytosol] (Homo sapiens)
        
        PGK1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P00558 PGK1

Gene Names

PGK1, PGKA, MIG10, OK/SW-cl.110

Chain

initiator methionine:1, chain:2-417

Reference Genes

BioGPS Gene:5230 PGK1

COSMIC - genes:PGK1 PGK1

CTD Gene:5230 PGK1

dbSNP Gene:5230 PGK1

ENSEMBL:ENSG00000102144 PGK1

HGNC:8896 PGK1

KEGG:hsa:5230 PGK1

Monarch:5230 PGK1

NCBI Gene:5230 PGK1

OMIM:311800 PGK1

UCSC:P00558 PGK1

Reference Transcript

RefSeq:NM_000291.4 PGK1

Participates

as a component of

as an input of

EsxA binds PGK1 (Homo sapiens)

as a member of

PGK monomers [cytosol] (Homo sapiens)

Inferred To

PGK1 [cytosol] (Bos taurus)

PGK1 [cytosol] (Caenorhabditis elegans)

PGK1 [cytosol] (Canis familiaris)

PGK1 [cytosol] (Danio rerio)

PGK1 [cytosol] (Dictyostelium discoideum)

PGK1 [cytosol] (Drosophila melanogaster)

PGK1 [cytosol] (Gallus gallus)

PGK1 [cytosol] (Mus musculus)

PGK1 [cytosol] (Plasmodium falciparum)

PGK1 [cytosol] (Rattus norvegicus)

PGK1 [cytosol] (Saccharomyces cerevisiae)

PGK1 [cytosol] (Schizosaccharomyces pombe)

PGK1 [cytosol] (Sus scrofa)

PGK1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_000282.1

OpenTargets

ENSG00000102144

ENSEMBL

ENST00000644362, ENSG00000102144, ENSP00000496140, ENST00000373316, ENSP00000362413

HPA

ENSG00000102144-PGK1

GeneCards

PGK1

PRO

P00558

Pharos - Targets

P00558

Orphanet

PGK1

GlyGen

P00558

HMDB Protein

HMDBP01528

PDB

3C3B, 2WZC, 2WZB, 4AXX, 2X15, 3C3A, 2ZGV, 5M6Z, 2Y3I, 3C39, 2WZD, 2XE8, 9FDN, 5M3U, 2XE7, 3ZOZ, 5O7D, 2X14, 2X13, 5MXM, 9FDH, 2XE6, 5M1R, 4O33, 3C3C, 5NP8, 8YHP, 2YBE

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07205 PGK2	1	PGK2 [cytosol] (R-HSA-6807622)	0.688	4
UniProt:P12004 PCNA	5	PCNA [nucleoplasm] (R-HSA-68439) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861)	0.573	2
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.544	2
UniProt:P15336 ATF2	2	p-T69,T71-ATF2 [nucleoplasm] (R-HSA-450243) ATF2 [nucleoplasm] (R-HSA-450336)	0.527	3
UniProt:O15379 HDAC3	2	HDAC3 [nucleoplasm] (R-HSA-442464) Unfolded HDAC3 [cytosol] (R-HSA-6813777)	0.524	2
UniProt:Q8TDX7 NEK7	2	NEK7 [cytosol] (R-HSA-2530599) p-S195-NEK7 [cytosol] (R-HSA-2984246)	0.499	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.483	7

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