Reactome | HNRNPH2 [nucleoplasm]

HNRNPH2 [nucleoplasm]

Stable Identifier

R-HSA-71943

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

hnRNP H', ROH2_HUMAN, Heterogeneous nuclear ribonucleoprotein H', FTP-3

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Homo sapiens)

- Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
  - Formation of pre-mRNPs (Homo sapiens)
    - Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
      - shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH2 [nucleoplasm] (Homo sapiens)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
      - Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH2 [nucleoplasm] (Homo sapiens)
  - mRNA Splicing (Homo sapiens)
    - mRNA Splicing - Major Pathway (Homo sapiens)
      - Formation of the Spliceosomal A complex (Homo sapiens)
        
        Spliceosomal A complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH2 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal E complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH2 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal B complex (Homo sapiens)
        
        Spliceosomal B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH2 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH2 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal B* complex (Homo sapiens)
        
        Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH2 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH2 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal Bact complex (Homo sapiens)
        
        Spliceosomal B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH2 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH2 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal C complex containing intron lariat (Homo sapiens)
        
        Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH2 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal C complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH2 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal C* complex (Homo sapiens)
        
        Spliceosomal C complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH2 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH2 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal E complex (Homo sapiens)
        
        Spliceosomal E complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH2 [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH2 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
        
        Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH2 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal P complex [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH2 [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal Pre-B complex (Homo sapiens)
        
        Spliceosomal A complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH2 [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH2 [nucleoplasm] (Homo sapiens)
      - Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
        
        Spliceosomal P complex [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH2 [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPH2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P55795 HNRNPH2

Gene Names

HNRNPH2, FTP3, HNRPH2

Chain

chain:1-449, initiator methionine:, chain:2-449

Reference Genes

BioGPS Gene:3188 HNRNPH2

COSMIC (genes):HNRNPH2 HNRNPH2

CTD Gene:3188 HNRNPH2

dbSNP Gene:3188 HNRNPH2

ENSEMBL:ENSG00000126945 HNRNPH2

HGNC:5042 HNRNPH2

KEGG:hsa:3188 HNRNPH2

Monarch:3188 HNRNPH2

NCBI Gene:3188 HNRNPH2

OMIM:300610 HNRNPH2

UCSC:P55795 HNRNPH2

Reference Transcript

Other Identifiers

11715779_a_at

11715780_x_at

11749449_s_at

201132_PM_at

201132_at

3188

3984780

3984781

3984784

3984785

3984786

41131_f_at

41132_r_at

8168852

A_14_P200617

A_23_P11286

A_33_P3255647

GE61294

GO:0003676

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005829

GO:0014069

GO:0016020

GO:0043226

GO:0043484

GO:1990904

HMNXSV003044173

ILMN_1781764

ILMN_2362245

PH_hs_0014308

TC0X002316.hg

U01923_at

g9624997_3p_at

Participates

as a component of

hnRNP proteins [nucleoplasm] (Homo sapiens)

as a member of

shuttling HNRNPs [nucleoplasm] (Homo sapiens)

Inferred To

HNRNPH1 [nucleoplasm] (Gallus gallus)

Homologues of HNRNPH1 [nucleoplasm] (Caenorhabditis elegans)

Homologues of HNRNPH1 [nucleoplasm] (Danio rerio)

hnrnph1l [nucleoplasm] (Danio rerio)

glo [nucleoplasm] (Drosophila melanogaster)

Hnrnph2 [nucleoplasm] (Mus musculus)

Hnrnph2 [nucleoplasm] (Rattus norvegicus)

hrpf-2 [nucleoplasm] (Caenorhabditis elegans)

HNRNPH2 [nucleoplasm] (Bos taurus)

HNRNPH2 [nucleoplasm] (Canis familiaris)

HNRNPH2 [nucleoplasm] (Sus scrofa)

hnrnph1 [nucleoplasm] (Danio rerio)

hnrnph1 [nucleoplasm] (Xenopus tropicalis)

hrpf-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001027565.1, NP_062543.1

ENSEMBL

ENSP00000361927, ENST00000316594

OpenTargets

ENSG00000126945

HPA

ENSG00000126945-HNRNPH2

PRO

P55795

Pharos - Targets

P55795

GlyGen

P55795

Orphanet

HNRNPH2

PDB

8SGH, 1WEZ, 6DG1, 1WG5

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43347 MSI1	1	MSI1 [cytosol] (R-HSA-9011403)	0.556	5
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	5
UniProt:P52597 HNRNPF	2	HNRNPF [nucleoplasm] (R-HSA-71937) HNRNPF [plasma membrane] (R-HSA-8950714)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	6
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.483	2