Reactome | ITGB4 [plasma membrane]

ITGB4 [plasma membrane]

Stable Identifier

R-HSA-215947

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Integrin beta-4

Locations in the PathwayBrowser

Expand all

Cell-Cell communication (Homo sapiens)

- Cell junction organization (Homo sapiens)
  - Type I hemidesmosome assembly (Homo sapiens)
    - BP180 interacts extracellularly with Laminin 332 (Homo sapiens)
      - Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
        
        Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
        
        Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
        
        ITGB4 [plasma membrane] (Homo sapiens)
      - Integrin alpha6:beta4:Plectin:BP180 complex [plasma membrane] (Homo sapiens)
        
        Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
        
        Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
        
        ITGB4 [plasma membrane] (Homo sapiens)
    - BP180 interacts intracellularly with plectin and integrin beta4 (Homo sapiens)
      - Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
        
        Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
        
        ITGB4 [plasma membrane] (Homo sapiens)
      - Integrin alpha6:beta4:Plectin:BP180 complex [plasma membrane] (Homo sapiens)
        
        Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
        
        Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
        
        ITGB4 [plasma membrane] (Homo sapiens)
    - BP230 interacts with keretin K5/K14 (Homo sapiens)
      - CD151:BP230:BP180:Plectin:Integrin alpha 6 beta 4: Laminin [plasma membrane] (Homo sapiens)
        
        BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
        
        Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
        
        Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
        
        Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
        
        ITGB4 [plasma membrane] (Homo sapiens)
      - Type II hemidesmosome [plasma membrane] (Homo sapiens)
        
        CD151:BP230:BP180:Plectin:Integrin alpha 6 beta 4: Laminin [plasma membrane] (Homo sapiens)
        
        BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
        
        Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
        
        Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
        
        Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
        
        ITGB4 [plasma membrane] (Homo sapiens)
    - BP230 is recruited to the hemidesmosome (Homo sapiens)
      - BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
        
        Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
        
        Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
        
        Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
        
        ITGB4 [plasma membrane] (Homo sapiens)
      - Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
        
        Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
        
        Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
        
        ITGB4 [plasma membrane] (Homo sapiens)
    - CD151 interacts with BP180 and the integrin alpha 6 subunit (Homo sapiens)
      - BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
        
        Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
        
        Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
        
        Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
        
        ITGB4 [plasma membrane] (Homo sapiens)
      - CD151:BP230:BP180:Plectin:Integrin alpha 6 beta 4: Laminin [plasma membrane] (Homo sapiens)
        
        BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
        
        Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
        
        Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
        
        Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
        
        ITGB4 [plasma membrane] (Homo sapiens)
    - Interaction of Plectin with Integrin beta 4 (Homo sapiens)
      - Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
        
        Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
        
        ITGB4 [plasma membrane] (Homo sapiens)
      - Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
        
        ITGB4 [plasma membrane] (Homo sapiens)

Extracellular matrix organization (Homo sapiens)

- Collagen formation (Homo sapiens)
  - Assembly of collagen fibrils and other multimeric structures (Homo sapiens)
    - Hemidesmosome formation (Homo sapiens)
      - Collagen type XVII fibril:Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
        
        Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
        
        ITGB4 [plasma membrane] (Homo sapiens)
      - Type I hemidesmosome complex [extracellular region] (Homo sapiens)
        
        Collagen type XVII fibril:Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
        
        Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
        
        ITGB4 [plasma membrane] (Homo sapiens)
- Laminin interactions (Homo sapiens)
  - Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Homo sapiens)
    - Integrin alpha3beta1, alpha6beta4 [plasma membrane] (Homo sapiens)
      - Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
        
        ITGB4 [plasma membrane] (Homo sapiens)
    - Integrin alpha3beta1, alpha6beta4:Laminins-332, 511, 521, (211, 221) [plasma membrane] (Homo sapiens)
      - Integrin alpha3beta1, alpha6beta4 [plasma membrane] (Homo sapiens)
        
        Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
        
        ITGB4 [plasma membrane] (Homo sapiens)
- Non-integrin membrane-ECM interactions (Homo sapiens)
  - Syndecan interactions (Homo sapiens)
    - Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Homo sapiens)
      - Integrin alpha2beta1, (alpha6beta4) [plasma membrane] (Homo sapiens)
        
        Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
        
        ITGB4 [plasma membrane] (Homo sapiens)
      - Syndecan-1:Integrin alpha2beta1 (alpha6beta4) [plasma membrane] (Homo sapiens)
        
        Integrin alpha2beta1, (alpha6beta4) [plasma membrane] (Homo sapiens)
        
        Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
        
        ITGB4 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P16144 ITGB4

Gene Names

ITGB4

Chain

signal peptide:1-27, chain:28-1822

Reference Genes

BioGPS Gene:3691 ITGB4

COSMIC (genes):ITGB4 ITGB4

CTD Gene:3691 ITGB4

dbSNP Gene:3691 ITGB4

ENSEMBL:ENSG00000132470 ITGB4

HGNC:6158 ITGB4

KEGG Gene (Homo sapiens):3691 ITGB4

Monarch:3691 ITGB4

NCBI Gene:3691 ITGB4

OMIM:147557 ITGB4

UCSC:P16144 ITGB4

Reference Transcript

Other Identifiers

0000840408

11724977_a_at

11724978_a_at

11726793_a_at

11726794_x_at

11726795_a_at

11733098_a_at

11733099_a_at

11752304_a_at

16837938

204989_s_at

204990_s_at

211905_s_at

214292_at

3691

3735152

3735153

3735154

3735155

3735157

3735158

3735159

3735160

3735161

3735162

3735164

3735165

3735166

3735167

3735168

3735169

3735170

3735172

3735174

3735176

3735177

3735180

3735182

3735183

3735185

3735187

3735189

3735190

3735192

3735196

3735197

3735198

3735199

3735201

3735202

3735204

3735206

3735207

3735208

3735210

3735212

3735213

3735214

3735215

3735217

3735218

3735219

38746_at

406_at

73285_i_at

73288_f_at

8009951

A_23_P66355

A_33_P3377364

GE59769

GE59785

GO:0000003

GO:0001664

GO:0003674

GO:0005178

GO:0005515

GO:0005575

GO:0005576

GO:0005604

GO:0005615

GO:0005622

GO:0005634

GO:0005635

GO:0005730

GO:0005886

GO:0005925

GO:0006914

GO:0006950

GO:0007154

GO:0007155

GO:0007160

GO:0007165

GO:0007229

GO:0008150

GO:0008305

GO:0009056

GO:0009611

GO:0009790

GO:0009925

GO:0009986

GO:0016020

GO:0016021

GO:0016477

GO:0022011

GO:0022607

GO:0030054

GO:0030056

GO:0030154

GO:0030198

GO:0030199

GO:0031012

GO:0031252

GO:0031581

GO:0031965

GO:0031994

GO:0032290

GO:0032991

GO:0033627

GO:0034330

GO:0035878

GO:0038132

GO:0040011

GO:0043226

GO:0043235

GO:0043589

GO:0046847

GO:0048333

GO:0048646

GO:0048856

GO:0048870

GO:0061450

GO:0070062

HMNXSV003037319

Hs.85266.0.S1_3p_a_at

Hs.85266.3.S1_3p_at

Hs.85266.3.S1_3p_x_at

ILMN_1653965

ILMN_1666451

ILMN_2253707

ILMN_2317543

ILMN_2334210

PH_hs_0004820

PH_hs_0040485

TC17000861.hg

X53587_at

g2293520_3p_a_at

g4504768_3p_a_at

Participates

as a component of

Integrin alpha6beta4 [plasma membrane] (Homo sapiens)

Inferred To

pat-3 [plasma membrane] (Caenorhabditis elegans)

ITGB4 [plasma membrane] (Bos taurus)

ITGB4 [plasma membrane] (Canis familiaris)

ITGB4 [plasma membrane] (Sus scrofa)

ITGB4 [plasma membrane] (Xenopus tropicalis)

Itgb4 [plasma membrane] (Mus musculus)

Itgb4 [plasma membrane] (Rattus norvegicus)

Homologues of ITGB4 [plasma membrane] (Drosophila melanogaster)

mys [plasma membrane] (Drosophila melanogaster)

Itgbn [plasma membrane] (Drosophila melanogaster)

itgb4 [plasma membrane] (Danio rerio)

Cross References

RefSeq

NP_001005619.1, NP_000204.3, NP_001005731.1, NP_001308052.1

Guide to Pharmacology - Targets

2458

OpenTargets

ENSG00000132470

GeneCards

P16144

HPA

ENSG00000132470-ITGB4

Ensembl

ENST00000200181, ENSG00000132470, ENSP00000400217, ENSP00000463651, ENSP00000200181, ENSP00000405536, ENST00000449880, ENST00000450894, ENST00000579662

PRO

P16144

Pharos - Targets

P16144

Orphanet

16275

GlyGen

P16144

PDB

4WTW, 3F7R, 3F7Q, 1QG3, 4WTX, 3FSO, 6GVL, 2YRZ, 4Q58, 3F7P, 3H6A, 6GVK, 3FQ4

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15149 PLEC	3	PLEC(1-2395) [cytosol] (R-HSA-350638) PLEC [cytosol] (R-HSA-201575) PLEC(2396-4684) [cytosol] (R-HSA-350618)	0.558	7
UniProt:Q05397 PTK2	11	pY-PTK2 [cytosol] (R-HSA-9632393) PTK2(773-1052) [cytosol] (R-HSA-202829) p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-6Y-PTK2 [cytosol] (R-HSA-354128) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2(1-772) [cytosol] (R-HSA-202827) PTK2 [cytosol] (R-HSA-201621) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006)	0.524	7
UniProt:Q99500 S1PR3	1	S1PR3 [plasma membrane] (R-HSA-419396)	0.471	3
UniProt:P48509 CD151	2	CD151 [plasma membrane] (R-HSA-913947) CD151 [cytosol] (R-HSA-446072)	0.463	2
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [ChEBI:16618]	6	PI(3,4,5)P3 [endocytic vesicle membrane] (R-ALL-917725) PI(3,4,5)P3 [endosome membrane] (R-ALL-917716) PI(3,4,5)P3 [plasma membrane] (R-ALL-179838) PIP3 [plasma membrane] (R-ALL-38117) PI(3,4,5)P3 [early endosome membrane] (R-ALL-8849955) PI(3,4,5)P3 [cytoplasmic vesicle membrane] (R-ALL-8874468)	0.462	2

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