Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
ITGB4 [plasma membrane]
Stable Identifier
R-HSA-215947
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Integrin beta-4
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Type I hemidesmosome assembly (Homo sapiens)
BP180 interacts extracellularly with Laminin 332 (Homo sapiens)
Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
Integrin alpha6:beta4:Plectin:BP180 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
BP180 interacts intracellularly with plectin and integrin beta4 (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
Integrin alpha6:beta4:Plectin:BP180 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
BP230 interacts with keretin K5/K14 (Homo sapiens)
CD151:BP230:BP180:Plectin:Integrin alpha 6 beta 4: Laminin [plasma membrane] (Homo sapiens)
BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
Type II hemidesmosome [plasma membrane] (Homo sapiens)
CD151:BP230:BP180:Plectin:Integrin alpha 6 beta 4: Laminin [plasma membrane] (Homo sapiens)
BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
BP230 is recruited to the hemidesmosome (Homo sapiens)
BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
CD151 interacts with BP180 and the integrin alpha 6 subunit (Homo sapiens)
BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
CD151:BP230:BP180:Plectin:Integrin alpha 6 beta 4: Laminin [plasma membrane] (Homo sapiens)
BP230:BP180:Plectin:integrin alpha 6 beta 4:Laminin 332 [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin:BP180:Laminin-322 complex [plasma membrane] (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
Interaction of Plectin with Integrin beta 4 (Homo sapiens)
Integrin alpha 6:beta 4:Plectin complex [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Collagen formation (Homo sapiens)
Assembly of collagen fibrils and other multimeric structures (Homo sapiens)
Hemidesmosome formation (Homo sapiens)
Collagen type XVII fibril:Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
Type I hemidesmosome complex [extracellular region] (Homo sapiens)
Collagen type XVII fibril:Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
Laminin interactions (Homo sapiens)
Integrins alpha3beta1, alpha6beta4 bind laminin-332, 511, 521, (211, 221) (Homo sapiens)
Integrin alpha3beta1, alpha6beta4 [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
Integrin alpha3beta1, alpha6beta4:Laminins-332, 511, 521, (211, 221) [plasma membrane] (Homo sapiens)
Integrin alpha3beta1, alpha6beta4 [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
Syndecan interactions (Homo sapiens)
Syndecan-1 binds Integrins alpha2beta1, (alpha6beta4) (Homo sapiens)
Integrin alpha2beta1, (alpha6beta4) [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
Syndecan-1:Integrin alpha2beta1 (alpha6beta4) [plasma membrane] (Homo sapiens)
Integrin alpha2beta1, (alpha6beta4) [plasma membrane] (Homo sapiens)
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
ITGB4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16144 ITGB4
Gene Names
ITGB4
Chain
signal peptide:1-27, chain:28-1822
Reference Genes
BioGPS Gene:3691 ITGB4
COSMIC (genes):ITGB4 ITGB4
CTD Gene:3691 ITGB4
dbSNP Gene:3691 ITGB4
ENSEMBL:ENSG00000132470.14 ITGB4
HGNC:6158 ITGB4
KEGG Gene (Homo sapiens):3691 ITGB4
Monarch:3691 ITGB4
NCBI Gene:3691 ITGB4
OMIM:147557 ITGB4
UCSC:P16144 ITGB4
Reference Transcript
RefSeq:NM_001005731.2 ITGB4
RefSeq:NM_001321123.1 ITGB4
RefSeq:NM_000213.4 ITGB4
RefSeq:NM_001005619.1 ITGB4
Other Identifiers
0000840408
11724977_a_at
11724978_a_at
11726793_a_at
11726794_x_at
11726795_a_at
11733098_a_at
11733099_a_at
11752304_a_at
16837938
204989_PM_s_at
204989_s_at
204990_PM_s_at
204990_s_at
211905_PM_s_at
211905_s_at
214292_PM_at
214292_at
3691
3735152
3735153
3735154
3735155
3735157
3735158
3735159
3735160
3735161
3735162
3735164
3735165
3735166
3735167
3735168
3735169
3735170
3735172
3735174
3735176
3735177
3735180
3735182
3735183
3735185
3735187
3735189
3735190
3735192
3735196
3735197
3735198
3735199
3735201
3735202
3735204
3735206
3735207
3735208
3735210
3735212
3735213
3735214
3735215
3735217
3735218
3735219
38746_at
406_at
73285_i_at
73288_f_at
8009951
A_23_P66355
A_33_P3377364
GE59769
GE59785
GO:0001664
GO:0005178
GO:0005515
GO:0005576
GO:0005604
GO:0005615
GO:0005622
GO:0005634
GO:0005635
GO:0005730
GO:0005886
GO:0005925
GO:0006914
GO:0007154
GO:0007155
GO:0007160
GO:0007229
GO:0008305
GO:0009611
GO:0009925
GO:0009986
GO:0016020
GO:0016021
GO:0016477
GO:0022011
GO:0022414
GO:0023052
GO:0030054
GO:0030056
GO:0030154
GO:0030312
GO:0031012
GO:0031252
GO:0031581
GO:0031965
GO:0031994
GO:0032290
GO:0032991
GO:0033627
GO:0034330
GO:0035878
GO:0038132
GO:0043226
GO:0043235
GO:0043589
GO:0046847
GO:0048333
GO:0048856
GO:0048870
GO:0061450
GO:0070062
GO:0070161
HMNXSV003037319
Hs.85266.0.S1_3p_a_at
Hs.85266.3.S1_3p_at
Hs.85266.3.S1_3p_x_at
ILMN_1653965
ILMN_1666451
ILMN_2253707
ILMN_2317543
ILMN_2334210
PH_hs_0004820
PH_hs_0040485
TC17000861.hg
X53587_at
g2293520_3p_a_at
g4504768_3p_a_at
Participates
as a component of
Integrin alpha6beta4 [plasma membrane] (Homo sapiens)
Inferred To
pat-3 [plasma membrane]
(Caenorhabditis elegans)
ITGB4 [plasma membrane]
(Bos taurus)
ITGB4 [plasma membrane]
(Canis familiaris)
ITGB4 [plasma membrane]
(Danio rerio)
ITGB4 [plasma membrane]
(Sus scrofa)
Itgb4 [plasma membrane]
(Mus musculus)
Itgb4 [plasma membrane]
(Rattus norvegicus)
Homologues of ITGB4 [plasma membrane]
(Drosophila melanogaster)
mys [plasma membrane]
(Drosophila melanogaster)
Itgbn [plasma membrane]
(Drosophila melanogaster)
itgb4 [plasma membrane]
(Xenopus tropicalis)
Cross References
RefSeq
NP_000204.3
,
NP_001308052.1
,
NP_001005619.1
,
NP_001005731.1
Guide to Pharmacology - Targets
2458
OpenTargets
ENSG00000132470
GeneCards
P16144
HPA
ENSG00000132470-ITGB4
Ensembl
ENSP00000400217
,
ENST00000450894
,
ENST00000579662
,
ENST00000200181
,
ENSP00000463651
,
ENSP00000200181
,
ENSP00000405536
,
ENST00000449880
,
ENSG00000132470
PRO
P16144
Pharos - Targets
P16144
Orphanet
16275
PDB
4WTW
,
3F7P
,
2YRZ
,
3FSO
,
1QG3
,
6GVL
,
4Q58
,
3FQ4
,
3H6A
,
3F7R
,
6GVK
,
4WTX
,
3F7Q
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q15149 PLEC
3
PLEC(2396-4684) [cytosol]
(R-HSA-350618)
PLEC(1-2395) [cytosol]
(R-HSA-350638)
PLEC [cytosol]
(R-HSA-201575)
0.558
7
UniProt:Q05397 PTK2
11
p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-HSA-8874613)
p-Y194,Y397-PTK2 [cytosol]
(R-HSA-8874600)
pY-PTK2 [cytosol]
(R-HSA-9632393)
p-5Y-PTK2 [cytosol]
(R-HSA-5218711)
p-5Y,S732-PTK2 [cytosol]
(R-HSA-5229006)
p-6Y,S732-PTK2 [cytosol]
(R-HSA-5218694)
PTK2(773-1052) [cytosol]
(R-HSA-202829)
PTK2(1-772) [cytosol]
(R-HSA-202827)
PTK2 [cytosol]
(R-HSA-201621)
p-Y397-PTK2 [cytosol]
(R-HSA-354068)
p-6Y-PTK2 [cytosol]
(R-HSA-354128)
0.524
7
UniProt:Q99500 S1PR3
1
S1PR3 [plasma membrane]
(R-HSA-419396)
0.471
3
UniProt:P48509 CD151
2
CD151 [cytosol]
(R-HSA-446072)
CD151 [plasma membrane]
(R-HSA-913947)
0.463
2
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text