Reactome | Polyglutamyl-TUBB3 [cytosol]

Polyglutamyl-TUBB3 [cytosol]

Stable Identifier

R-HSA-8867464

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TUBB3, beta tubulin 4

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Carboxyterminal post-translational modifications of tubulin (Homo sapiens)
    - CCPs deglutamylate tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin:GDP [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBB3 [cytosol] (Homo sapiens)
    - Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin:GDP [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBB3 [cytosol] (Homo sapiens)
    - TTLLs polyglutamylate tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin:GDP [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBB3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13509 TUBB3

Gene Names

TUBB3, TUBB4

Chain

chain:1-450

Reference Genes

BioGPS Gene:10381 TUBB3

COSMIC (genes):TUBB3 TUBB3

CTD Gene:10381 TUBB3

dbSNP Gene:10381 TUBB3

ENSEMBL:ENSG00000258947 TUBB3

ENSEMBL:ENSG00000258947.8 TUBB3

HGNC:20772 TUBB3

KEGG Gene (Homo sapiens):10381 TUBB3

Monarch:10381 TUBB3

NCBI Gene:10381 TUBB3

OMIM:602661 TUBB3

UCSC:Q13509 TUBB3

Reference Transcript

Other Identifiers

10381

11754593_x_at

202154_PM_x_at

202154_x_at

213476_3p_x_at

213476_PM_x_at

213476_x_at

2916784

33678_i_at

3674512

3674513

3674515

3674516

3674518

3674521

3674527

3674528

3674529

3674530

4050505

471_f_at

57034_at

7998063

A_14_P128910

A_23_P77493

A_24_P258633

GO:0000166

GO:0000226

GO:0000278

GO:0003824

GO:0003924

GO:0005198

GO:0005200

GO:0005515

GO:0005525

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005856

GO:0005874

GO:0007010

GO:0007017

GO:0007411

GO:0015630

GO:0016787

GO:0023052

GO:0030027

GO:0030154

GO:0030175

GO:0030182

GO:0030424

GO:0030425

GO:0030426

GO:0038007

GO:0042277

GO:0042995

GO:0043025

GO:0043226

GO:0045171

GO:0046872

GO:0048856

GO:0070062

GO:0071944

GO:0072686

GO:1990791

GO:1990890

HMNXSV003003269

HMNXSV003007557

Hs.159154.1.A1_3p_x_at

ILMN_1791726

PH_hs_0030611

TC16001720.hg

U47634_at

g5174736_3p_a_at

Participates

as a candidate of

Polyglutamyl beta tubulin [cytosol] (Homo sapiens)

Other forms of this molecule

TUBB3 folding intermediate [cytosol]

TUBB3 unfolded [cytosol]

Polyglycyl-TUBB3 [cytosol]

TUBB3 [axonemal microtubule]

TUBB3 [cytosol]

Inferred To

Polyglutamyl-TUBB3 [cytosol] (Bos taurus)

Polyglutamyl-TUBB3 [cytosol] (Dictyostelium discoideum)

Polyglutamyl-TUBB3 [cytosol] (Gallus gallus)

Polyglutamyl-TUBB3 [cytosol] (Mus musculus)

Polyglutamyl-TUBB3 [cytosol] (Plasmodium falciparum)

Polyglutamyl-TUBB3 [cytosol] (Rattus norvegicus)

Polyglutamyl-TUBB3 [cytosol] (Saccharomyces cerevisiae)

Polyglutamyl-TUBB3 [cytosol] (Schizosaccharomyces pombe)

tubb3 [cytosol] (Xenopus tropicalis)

TUBB3 [cytosol] (Sus scrofa)

Modified Residues

Name

L-isoglutamyl-polyglutamic acid at unknown position

PsiMod Name

L-isoglutamyl-polyglutamic acid

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl-polyglutamic acid, forming an isopeptide bond with a polyglutamic acid.

Cross References

RefSeq

NP_001184110.1, NP_006077.2

ZINC - World Drugs

TBB3_HUMAN

Guide to Pharmacology - Targets

2752

OpenTargets

ENSG00000258947

ZINC - FDA approved

TBB3_HUMAN

ZINC - Substances

TBB3_HUMAN

ZINC target

Q13509

ZINC - Biogenic

TBB3_HUMAN

PRO

Q13509

PDB

7PJF, 7SJ8, 7M18, 7LXB, 7SJ7, 5IJ0, 7M20, 7SJA, 6WSL, 6E7B, 5JCO, 6S8L, 7Z6S, 7SJ9, 5IJ9

HPA

ENSG00000258947-TUBB3

GeneCards

Q13509

Ensembl

ENSP00000451617, ENSP00000320295, ENSG00000258947, ENST00000315491, ENST00000554444

Pharos - Targets

Q13509

Orphanet

19021

ZINC - Predictions - Purchasable

TBB3_HUMAN

HMDB Protein

HMDBP02218

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.482	2