Reactome | Polyglutamyl-TUBB3 [cytosol]

Polyglutamyl-TUBB3 [cytosol]

Stable Identifier

R-HSA-8867464

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TUBB3, beta tubulin 4

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Carboxyterminal post-translational modifications of tubulin (Homo sapiens)
    - CCPs deglutamylate tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin:GDP [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBB3 [cytosol] (Homo sapiens)
    - Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin:GDP [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBB3 [cytosol] (Homo sapiens)
    - TTLLs polyglutamylate tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin:GDP [cytosol] (Homo sapiens)
        
        Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBB3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13509 TUBB3

Gene Names

TUBB3, TUBB4

Chain

chain:1-450

Reference Genes

BioGPS Gene:10381 TUBB3

COSMIC (genes):TUBB3 TUBB3

CTD Gene:10381 TUBB3

dbSNP Gene:10381 TUBB3

ENSEMBL:ENSG00000258947 TUBB3

HGNC:20772 TUBB3

KEGG:hsa:10381 TUBB3

Monarch:10381 TUBB3

NCBI Gene:10381 TUBB3

OMIM:602661 TUBB3

UCSC:Q13509 TUBB3

Reference Transcript

Other Identifiers

10381

11754593_x_at

16822161

202154_PM_x_at

202154_x_at

213476_3p_x_at

213476_PM_x_at

213476_x_at

2916784

33678_i_at

3674512

3674513

3674515

3674516

3674517

3674518

3674519

3674520

3674521

3674522

3674523

3674524

3674525

3674526

3674527

3674528

3674529

3674530

3674553

3674556

4050505

471_f_at

57034_at

7998063

A_14_P128910

A_14_P200447

A_23_P77493

A_24_P258633

GE59191

GO:0000226

GO:0000278

GO:0003824

GO:0003924

GO:0005198

GO:0005200

GO:0005515

GO:0005525

GO:0005634

GO:0005737

GO:0005819

GO:0005856

GO:0005874

GO:0007010

GO:0007017

GO:0007411

GO:0015630

GO:0016787

GO:0030027

GO:0030154

GO:0030175

GO:0030182

GO:0030424

GO:0030425

GO:0030426

GO:0038007

GO:0042277

GO:0042995

GO:0043025

GO:0043226

GO:0045171

GO:0046872

GO:0048856

GO:0070062

GO:0071944

GO:0072686

GO:1990791

GO:1990890

HMNXSV003003269

HMNXSV003007557

Hs.159154.1.A1_3p_x_at

ILMN_1791726

PH_hs_0030611

PH_hs_0040396

TC16001720.hg

U47634_at

g5174736_3p_a_at

Participates

as a candidate of

Polyglutamyl beta tubulin [cytosol] (Homo sapiens)

Other forms of this molecule

TUBB3 [cytosol]

TUBB3 [axonemal microtubule]

Polyglycyl-TUBB3 [cytosol]

TUBB3 unfolded [cytosol]

TUBB3 folding intermediate [cytosol]

Inferred To

Polyglutamyl-TUBB3 [cytosol] (Bos taurus)

Polyglutamyl-TUBB3 [cytosol] (Dictyostelium discoideum)

Polyglutamyl-TUBB3 [cytosol] (Mus musculus)

Polyglutamyl-TUBB3 [cytosol] (Plasmodium falciparum)

Polyglutamyl-TUBB3 [cytosol] (Rattus norvegicus)

tubb3 [cytosol] (Xenopus tropicalis)

TUBB3 [cytosol] (Canis familiaris)

TUBB3 [cytosol] (Sus scrofa)

Modified Residues

Name

L-isoglutamyl-polyglutamic acid at unknown position

PsiMod Name

L-isoglutamyl-polyglutamic acid

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl-polyglutamic acid, forming an isopeptide bond with a polyglutamic acid.

Cross References

RefSeq

NP_006077.2, NP_001184110.1

Guide to Pharmacology - Targets

2752

OpenTargets

ENSG00000258947

ENSEMBL

ENSP00000320295, ENSG00000258947, ENSP00000451617, ENST00000554444, ENST00000315491

ZINC - FDA approved

TBB3_HUMAN

ZINC - Substances

TBB3_HUMAN

ZINC - Biogenic

TBB3_HUMAN

ZINC target

Q13509

PRO

Q13509

GlyGen

Q13509

PDB

6S8L, 7SJA, 6E7B, 5IJ0, 7SJ8, 7SJ7, 7SJ9, 7Z6S, 5JCO, 8VT7, 5IJ9, 7M18, 7LXB, 6WSL, 7M20, 8VRJ, 7PJF, 8VRK

HPA

ENSG00000258947-TUBB3

GeneCards

TUBB3

Pharos - Targets

Q13509

Orphanet

TUBB3

ZINC - Predictions - Purchasable

TBB3_HUMAN

HMDB Protein

HMDBP02218

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9HC77 CENPJ	2	CENPJ [cytosol] (R-HSA-380291) p-S589,S595-CENPJ [cytosol] (R-HSA-6801670)	0.527	2
UniProt:P07437 TUBB	3	TUBB [extracellular region] (R-HSA-380317) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [cytosol] (R-HSA-9020816)	0.527	3
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.527	2
UniProt:Q6UWV6 ENPP7	1	ENPP7 [plasma membrane] (R-HSA-1631583)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	5
UniProt:P08173 CHRM4	1	CHRM4 [plasma membrane] (R-HSA-390693)	0.527	2
UniProt:Q03405 PLAUR	7	GPI-PLAUR [specific granule membrane] (R-HSA-6806143) PLAUR [plasma membrane] (R-HSA-6806165) GPI-PLAUR [plasma membrane] (R-HSA-158946) PLAUR(23-335) [endoplasmic reticulum membrane] (R-HSA-162866) PLAUR(306-335) [endoplasmic reticulum lumen] (R-HSA-162707) GPI-PLAUR [endoplasmic reticulum membrane] (R-HSA-162687) PLAUR [endoplasmic reticulum membrane] (R-HSA-162703)	0.527	2
UniProt:Q8N0Z6 TTC5	3	p-S203,S221-TTC5 [nucleoplasm] (R-HSA-6804259) p-S203-TTC5 [nucleoplasm] (R-HSA-6804261) TTC5 [nucleoplasm] (R-HSA-6804264)	0.527	2
UniProt:Q15398 DLGAP5	1	DLGAP5 [cytosol] (R-HSA-264452)	0.527	3
UniProt:Q07954 LRP1	2	LRP1 [plasma membrane] (R-HSA-1454844) LRP1 [endocytic vesicle membrane] (R-HSA-2230981)	0.527	2
UniProt:P01222 TSHB	1	TSHB [extracellular region] (R-HSA-378957)	0.527	2
UniProt:Q9HC35 EML4	12	EML4 [cytosol] (R-HSA-9647741) p-S,T-EML4 [cytosol] (R-HSA-9648096) EML4(1-496)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699812) EML4(1-223)-ALK(1059-1620) fusion [cytosol] (R-HSA-9699862) EML4(1-223)insKMSTREKNSQV-ALK(1059-1620) fusion [cytosol] (R-HSA-9699813) EML4(1-780)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9716113) EML4(1-569)-p-7Y-ALK(1078-1620) fusion [cytosol] (R-HSA-9716116) EML4(1-223)-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9699903) EML4(1-223)insKMSTREKNSQV-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9699885) EML4(1-486)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699918) EML4(1-569)-ALK(1078-1620) fusion [cytosol] (R-HSA-9716112) EML4(1-780)-ALK(1058-1620) fusion [cytosol] (R-HSA-9716119)	0.527	2
UniProt:Q8N307 MUC20	19	MUC20 [plasma membrane] (R-HSA-8851833) GalNAc-MUC20 [plasma membrane] (R-HSA-8858516) Core 2 (MUC20) [Golgi lumen] (R-HSA-1462330) Core 2a (MUC20) [Golgi lumen] (R-HSA-6784267) GalNAc-MUC20 [Golgi lumen] (R-HSA-1463443) Sialyl Tn antigen (MUC20) [Golgi lumen] (R-HSA-1463558) T-antigen (MUC20) [Golgi lumen] (R-HSA-1462188) Sialyl-2,3 T-antigen (MUC20) [Golgi lumen] (R-HSA-1463479) Sialyl T-antigen (MUC20) [Golgi lumen] (R-HSA-1463469) Disialyl T-antigen (MUC20) [Golgi lumen] (R-HSA-1463482) MUC20 [Golgi lumen] (R-HSA-913634) Core 6 (MUC20) [Golgi lumen] (R-HSA-1462247) extended Core 6 (MUC20) [Golgi lumen] (R-HSA-1967016) Core 7 (MUC20) [Golgi lumen] (R-HSA-1462236) Core 3 (MUC20) [Golgi lumen] (R-HSA-1462344) Core 4 (MUC20) [Golgi lumen] (R-HSA-1462266) Core 5 (MUC20) [Golgi lumen] (R-HSA-1462128) Core 2S (MUC20) [Golgi lumen] (R-HSA-6786382) Core 8 (MUC20) [Golgi lumen] (R-HSA-1462329)	0.527	2
UniProt:Q9Y337 KLK5	4	KLK5 [extracellular region] (R-HSA-8849629) proKLK5 [extracellular region] (R-HSA-8849836) KLK5 propeptide [extracellular region] (R-HSA-8849839) KLK5 [cytosol] (R-HSA-8934778)	0.527	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	9
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.482	2

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