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Polyglutamyl-TUBB3 [cytosol]
Stable Identifier
R-HSA-8867464
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
TUBB3, beta tubulin 4
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Carboxyterminal post-translational modifications of tubulin (Homo sapiens)
CCPs deglutamylate tubulin (Homo sapiens)
Polyglutamylated microtubule [cytosol] (Homo sapiens)
Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
Polyglutamyl beta tubulin:GDP [cytosol] (Homo sapiens)
Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
Polyglutamyl-TUBB3 [cytosol] (Homo sapiens)
Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)
Polyglutamylated microtubule [cytosol] (Homo sapiens)
Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
Polyglutamyl beta tubulin:GDP [cytosol] (Homo sapiens)
Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
Polyglutamyl-TUBB3 [cytosol] (Homo sapiens)
TTLLs polyglutamylate tubulin (Homo sapiens)
Polyglutamylated microtubule [cytosol] (Homo sapiens)
Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
Polyglutamyl beta tubulin:GDP [cytosol] (Homo sapiens)
Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
Polyglutamyl-TUBB3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13509 TUBB3
Gene Names
TUBB3, TUBB4
Chain
chain:1-450
Reference Genes
BioGPS Gene:10381 TUBB3
COSMIC (genes):TUBB3 TUBB3
CTD Gene:10381 TUBB3
dbSNP Gene:10381 TUBB3
ENSEMBL:ENSG00000258947 TUBB3
ENSEMBL:ENSG00000258947.8 TUBB3
HGNC:20772 TUBB3
KEGG Gene (Homo sapiens):10381 TUBB3
Monarch:10381 TUBB3
NCBI Gene:10381 TUBB3
OMIM:602661 TUBB3
UCSC:Q13509 TUBB3
Reference Transcript
RefSeq:NM_006086.3 TUBB3
RefSeq:NM_001197181.1 TUBB3
Other Identifiers
10381
11754593_x_at
202154_PM_x_at
202154_x_at
213476_3p_x_at
213476_PM_x_at
213476_x_at
2916784
33678_i_at
3674512
3674513
3674515
3674516
3674518
3674521
3674527
3674528
3674529
3674530
4050505
471_f_at
57034_at
7998063
A_14_P128910
A_23_P77493
A_24_P258633
GO:0000166
GO:0000226
GO:0000278
GO:0003824
GO:0003924
GO:0005198
GO:0005200
GO:0005515
GO:0005525
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005856
GO:0005874
GO:0007010
GO:0007017
GO:0007411
GO:0015630
GO:0016787
GO:0023052
GO:0030027
GO:0030154
GO:0030175
GO:0030182
GO:0030424
GO:0030425
GO:0030426
GO:0038007
GO:0042277
GO:0042995
GO:0043025
GO:0043226
GO:0045171
GO:0046872
GO:0048856
GO:0070062
GO:0071944
GO:0072686
GO:1990791
GO:1990890
HMNXSV003003269
HMNXSV003007557
Hs.159154.1.A1_3p_x_at
ILMN_1791726
PH_hs_0030611
TC16001720.hg
U47634_at
g5174736_3p_a_at
Participates
as a candidate of
Polyglutamyl beta tubulin [cytosol] (Homo sapiens)
Other forms of this molecule
TUBB3 folding intermediate [cytosol]
TUBB3 unfolded [cytosol]
Polyglycyl-TUBB3 [cytosol]
TUBB3 [axonemal microtubule]
TUBB3 [cytosol]
Inferred To
Polyglutamyl-TUBB3 [cytosol]
(Bos taurus)
Polyglutamyl-TUBB3 [cytosol]
(Dictyostelium discoideum)
Polyglutamyl-TUBB3 [cytosol]
(Gallus gallus)
Polyglutamyl-TUBB3 [cytosol]
(Mus musculus)
Polyglutamyl-TUBB3 [cytosol]
(Plasmodium falciparum)
Polyglutamyl-TUBB3 [cytosol]
(Rattus norvegicus)
Polyglutamyl-TUBB3 [cytosol]
(Saccharomyces cerevisiae)
Polyglutamyl-TUBB3 [cytosol]
(Schizosaccharomyces pombe)
tubb3 [cytosol]
(Xenopus tropicalis)
TUBB3 [cytosol]
(Sus scrofa)
Modified Residues
Name
L-isoglutamyl-polyglutamic acid at unknown position
PsiMod Name
L-isoglutamyl-polyglutamic acid
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl-polyglutamic acid, forming an isopeptide bond with a polyglutamic acid.
Cross References
RefSeq
NP_001184110.1
,
NP_006077.2
ZINC - World Drugs
TBB3_HUMAN
Guide to Pharmacology - Targets
2752
OpenTargets
ENSG00000258947
ZINC - FDA approved
TBB3_HUMAN
ZINC - Substances
TBB3_HUMAN
ZINC target
Q13509
ZINC - Biogenic
TBB3_HUMAN
PRO
Q13509
PDB
7PJF
,
7SJ8
,
7M18
,
7LXB
,
7SJ7
,
5IJ0
,
7M20
,
7SJA
,
6WSL
,
6E7B
,
5JCO
,
6S8L
,
7Z6S
,
7SJ9
,
5IJ9
HPA
ENSG00000258947-TUBB3
GeneCards
Q13509
Ensembl
ENSP00000451617
,
ENSP00000320295
,
ENSG00000258947
,
ENST00000315491
,
ENST00000554444
Pharos - Targets
Q13509
Orphanet
19021
ZINC - Predictions - Purchasable
TBB3_HUMAN
HMDB Protein
HMDBP02218
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.482
2
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