Reactome | GLO1 [cytosol]

GLO1 [cytosol]

Stable Identifier

R-HSA-5694127

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Lactoylglutathione lyase ecNumber4.4.1.5/ecNumber, LGUL_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q04760 GLO1

Gene Names

GLO1

Chain

initiator methionine:, chain:2-184

Reference Genes

BioGPS Gene:2739 GLO1

COSMIC (genes):GLO1 GLO1

CTD Gene:2739 GLO1

dbSNP Gene:2739 GLO1

ENSEMBL:ENSG00000124767 GLO1

ENSEMBL_homo_sapiens_GENE:ENSG00000124767.7 GLO1

HGNC:4323 GLO1

KEGG Gene (Homo sapiens):2739 GLO1

Monarch:2739 GLO1

NCBI Gene:2739 GLO1

OMIM:138750 GLO1

Reference Transcript

RefSeq:NM_006708.2 GLO1

Other Identifiers

11716284_s_at

11746439_a_at

11746440_s_at

11755293_a_at

17018812

200681_PM_at

200681_at

2739

2952678

2952680

2952681

2952682

2952683

2952684

2952685

2952686

2952688

2952689

2952699

2952700

36201_at

8126135

A_23_P214411

D13315_at

GE57057

GO:0003824

GO:0004462

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0005975

GO:0006351

GO:0006355

GO:0006357

GO:0006575

GO:0006749

GO:0006790

GO:0008270

GO:0009438

GO:0012501

GO:0016829

GO:0030154

GO:0030316

GO:0043066

GO:0043226

GO:0046872

GO:0048856

GO:0070062

HMNXSV003009356

ILMN_1702177

PH_hs_0023325

TC06001692.hg

g5729841_3p_at

Participates

as a component of

GLO1 dimer:2xZn2+ [cytosol] (Homo sapiens)

Inferred To

Ghost homologue of GLO1 [cytosol] (Xenopus tropicalis)

GLO1 [cytosol] (Bos taurus)

GLO1 [cytosol] (Canis familiaris)

GLO1 [cytosol] (Danio rerio)

GLO1 [cytosol] (Drosophila melanogaster)

GLO1 [cytosol] (Gallus gallus)

GLO1 [cytosol] (Mus musculus)

GLO1 [cytosol] (Plasmodium falciparum)

GLO1 [cytosol] (Rattus norvegicus)

GLO1 [cytosol] (Saccharomyces cerevisiae)

GLO1 [cytosol] (Schizosaccharomyces pombe)

GLO1 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_006699.2

ZINC - World Drugs

LGUL_HUMAN

OpenTargets

ENSG00000124767

ZINC - Substances

LGUL_HUMAN

ZINC - Biogenic

LGUL_HUMAN

ZINC target

Q04760

PRO

Q04760

PDB

1QIP, 7WT0, 3W0U, 1BH5, 1FRO, 7WT1, 7WSZ, 1QIN, 7WT2, 3W0T, 3VW9

ZINC - Metabolites

LGUL_HUMAN

HPA

ENSG00000124767-GLO1

GeneCards

Q04760

Ensembl

ENSP00000362463, ENSG00000124767, ENST00000373365

Pharos - Targets

Q04760

ZINC - Predictions - Purchasable

LGUL_HUMAN

HMDB Protein

HMDBP00392

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	16

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