Reactome | SRRM2 [nucleoplasm]

SRRM2 [nucleoplasm]

Stable Identifier

R-HSA-8865888

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Serine/arginine repetitive matrix protein 2, SRRM2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UQ35 SRRM2

Gene Names

SRRM2, KIAA0324, SRL300, SRM300, HSPC075

Chain

chain:1-2752

Reference Genes

BioGPS Gene:23524 SRRM2

COSMIC (genes):SRRM2 SRRM2

CTD Gene:23524 SRRM2

dbSNP Gene:23524 SRRM2

ENSEMBL:ENSG00000167978 SRRM2

HGNC:16639 SRRM2

KEGG:hsa:23524 SRRM2

Monarch:23524 SRRM2

NCBI Gene:23524 SRRM2

OMIM:606032 SRRM2

UCSC:Q9UQ35 SRRM2

Reference Transcript

RefSeq:NM_016333.3 SRRM2

Other Identifiers

11716511_x_at

11716512_a_at

11753062_a_at

11758214_s_at

11761450_x_at

1554671_PM_a_at

1554671_a_at

16815208

207435_PM_s_at

207435_s_at

208610_PM_s_at

208610_s_at

216629_3p_at

216629_PM_at

216629_at

23524

32761_at

3645254

3645255

3645256

3645257

3645258

3645259

3645260

3645261

3645262

3645263

3645264

3645265

3645266

3645267

3645268

3645269

3645270

3645271

3645272

3645273

3645274

3645275

3645276

3645277

3645278

3645279

3645280

3645281

3645282

3645283

3645284

3645285

3645286

3645287

3645288

3645289

3645290

3645291

3645292

3645293

3645294

3645295

3645296

3645297

3645298

3645299

3645300

3645301

3645302

3645303

3645304

3645305

3645306

3645307

3645308

3645309

3645310

3645311

3645312

3645313

3645314

3645315

65441_at

78525_at

78527_g_at

7992692

A_14_P107512

A_14_P109151

A_14_P122994

A_23_P323166

A_24_P50988

A_33_P3353343

GE82107

GO:0000398

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0006397

GO:0008380

GO:0015030

GO:0016071

GO:0016607

GO:0043226

GO:0070742

GO:0071005

GO:0071007

GO:0071013

HMNXSV003002336

HMNXSV003014284

HMNXSV003039584

Hs.197114.1.S1_3p_s_at

Hs.197114.2.S1_3p_a_at

Hs.197114.2.S1_3p_at

Hs2.197114.3.S1_3p_s_at

ILMN_1734602

PH_hs_0025277

TC16000084.hg

TC16001389.hg

g7706718_3p_a_at

Participates

as an input of

Formation of the Spliceosomal E complex (Homo sapiens)

as a component of

as an output of

Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)

Inferred To

Ghost homologue of SRRM2 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of SRRM2 [nucleoplasm] (Danio rerio)

Ghost homologue of SRRM2 [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of SRRM2 [nucleoplasm] (Drosophila melanogaster)

Ghost homologue of SRRM2 [nucleoplasm] (Gallus gallus)

Ghost homologue of SRRM2 [nucleoplasm] (Plasmodium falciparum)

Ghost homologue of SRRM2 [nucleoplasm] (Schizosaccharomyces pombe)

SRRM2 [nucleoplasm] (Bos taurus)

SRRM2 [nucleoplasm] (Canis familiaris)

SRRM2 [nucleoplasm] (Sus scrofa)

srrm2 [nucleoplasm] (Xenopus tropicalis)

Srrm2 [nucleoplasm] (Mus musculus)

Srrm2 [nucleoplasm] (Rattus norvegicus)

Cross References

OpenTargets

ENSG00000167978

ENSEMBL

ENSP00000301740, ENST00000301740, ENSP00000461181, ENSG00000167978, ENST00000576924

HPA

ENSG00000167978-SRRM2

GeneCards

SRRM2

PRO

Q9UQ35

Pharos - Targets

Q9UQ35

GlyGen

Q9UQ35

PDB

6FF4, 6FF7, 8I0V, 7DVQ, 8I0U, 8I0T, 9FMD, 6ICZ, 5XJC, 8CH6, 7QTT, 8I0S, 8I0R, 7W5B, 5Z57, 5Z56, 7W5A, 5YZG, 6QDV, 7W59, 7A5P, 6ZYM, 8I0W, 5MQF, 8C6J

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.806	6
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.706	4
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.674	3
UniProt:Q8TAD8 SNIP1	1	SNIP1 [nucleoplasm] (R-HSA-3222315)	0.659	3
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.643	3
UniProt:Q96SB4 SRPK1	2	SRPK1 [cytosol] (R-HSA-9729349) SRPK1 [nucleoplasm] (R-HSA-9821984)	0.643	3
UniProt:P49761 CLK3			0.643	3
UniProt:P09234 SNRPC	1	SNRPC [nucleoplasm] (R-HSA-8865876)	0.643	3
UniProt:P26045 PTPN3	3	PTPN3 [cytosol] (R-HSA-8867650) p-S459 PTPN3 [cytosol] (R-HSA-8868111) PTPN3 [plasma membrane] (R-HSA-5490317)	0.569	3
UniProt:O60285 NUAK1	2	p-T211-NUAK1 [nucleoplasm] (R-HSA-3222011) NUAK1 [nucleoplasm] (R-HSA-3222004)	0.564	2
UniProt:Q08170 SRSF4	1	SRSF4 [nucleoplasm] (R-HSA-72024)	0.547	2
UniProt:Q9UJV9 DDX41	4	DDX41 [nucleoplasm] (R-HSA-9769601) DDX41 [cytosol] (R-HSA-3134807) K48polyUb-DDX41 [cytosol] (R-HSA-3134942) K48polyUb-DDX41 [cytosol] (R-HSA-3134941)	0.527	2
UniProt:Q9UER7 DAXX	13	DAXX [nucleoplasm] (R-HSA-3222068) DAXX A36Qfs108 [nucleoplasm] (R-HSA-9673105) DAXX K56 [nucleoplasm] (R-HSA-9673089) DAXX A103Sfs40 [nucleoplasm] (R-HSA-9673121) DAXX C106 [nucleoplasm] (R-HSA-9673079) DAXX E72Nfs72 [nucleoplasm] (R-HSA-9673110) DAXX E104 [nucleoplasm] (R-HSA-9673078) DAXX H26Tfs118 [nucleoplasm] (R-HSA-9673114) DAXX S138 [nucleoplasm] (R-HSA-9673081) DAXX C74* [nucleoplasm] (R-HSA-9673096) DAXX R48Vfs93 [nucleoplasm] (R-HSA-9673103) DAXX L98Vfs13 [nucleoplasm] (R-HSA-9673102) monoSUMO1-K630,K631-DAXX [nucleoplasm] (R-HSA-4086086)	0.527	3
UniProt:P21741 MDK	1	MDK [extracellular region] (R-HSA-2160953)	0.527	2
UniProt:O43491 EPB41L2	1	EPB41L2 [cytosol] (R-HSA-6797548)	0.527	3
UniProt:P08621 SNRNP70	1	SNRNP70 [nucleoplasm] (R-HSA-71913)	0.527	3
UniProt:P48426 PIP4K2A	2	PIP4K2A [cytosol] (R-HSA-1604641) PIP4K2A [nucleoplasm] (R-HSA-6811484)	0.527	2
UniProt:Q9Y2J2 EPB41L3	1	EPB41L3 [cytosol] (R-HSA-6797563)	0.527	3
UniProt:P49760 CLK2			0.527	3
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.527	2
UniProt:Q8NCB2 CAMKV			0.527	2
UniProt:Q92731 ESR2	5	ESR2 [cytosol] (R-HSA-9020970) ESR2 [nucleoplasm] (R-HSA-446165) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) PalmS-ESR2 [plasma membrane] (R-HSA-9021059) PalmS-ESR2 [cytosol] (R-HSA-9020979)	0.527	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	10
UniProt:P04608 tat	1	Tat (P04608) [nucleoplasm] (R-HIV-175856)	0.462	2

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