Reactome | DCTN1(1-1065)-p-7Y-ALK(1058-1620) fusion [cytosol]

DCTN1(1-1065)-p-7Y-ALK(1058-1620) fusion [cytosol]

Stable Identifier

R-HSA-9711959

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Dynactin subunit 1, DCTN1_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
24445538	Kinase fusions are frequent in Spitz tumours and spitzoid melanomas Wiesner, T, He, J, Yelensky, R, Esteve-Puig, R, Botton, T, Yeh, I, Lipson, D, Otto, G, Brennan, K, Murali, R, Garrido, M, Miller, VA, Ross, JS, Berger, MF, Sparatta, A, Palmedo, G, Cerroni, L, Busam, KJ, Kutzner, H, Cronin, MT, Stephens, PJ, Bastian, BC	Nat Commun	2014

External Reference Information

External Reference

UniProt:Q14203 DCTN1

Gene Names

DCTN1

Chain

chain:1-1278

Reference Genes

BioGPS Gene:1639 DCTN1

COSMIC (genes):DCTN1 DCTN1

CTD Gene:1639 DCTN1

dbSNP Gene:1639 DCTN1

ENSEMBL:ENSG00000204843 DCTN1

HGNC:2711 DCTN1

KEGG:hsa:1639 DCTN1

Monarch:1639 DCTN1

NCBI Gene:1639 DCTN1

OMIM:601143 DCTN1

UCSC:Q14203 DCTN1

Reference Transcript

Participates

as a component of

DCTN1(1-1065)-p-7Y ALK(1058-1620) fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

DCTN1 [cytosol]

DCTN1(1-1177)-p-7Y-ALK(1058-1620) fusion [cytosol]

DCTN1(1-599)-p-7Y-ALK(1058-1620) fusion [cytosol]

DCTN1(1-1177)-ALK(1058-1620) fusion [cytosol]

DCTN1(1-599)-ALK(1058-1620) fusion [cytosol]

DCTN1(1-1065)-ALK(1058-1620) fusion [cytosol]

Modified Residues

Name

Insertion of residues 1058 to 1620 at 1066 from UniProt:Q9UM73 ALK

Coordinate

1066

Name

O4'-phospho-L-tyrosine at 1096

Coordinate

1096

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1278

Coordinate

1278

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1282

Coordinate

1282

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1283

Coordinate

1283

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1359

Coordinate

1359

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1507

Coordinate

1507

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1604

Coordinate

1604

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Disease

Name	Identifier	Synonyms
malignant spindle cell melanoma	DOID:3162	spindle cell malignant melanoma, Spitzoid malignant melanoma, spindle cell melanoma, desmoplastic melanoma

Cross References

RefSeq

NP_075408.1, NP_004073.2, NP_001177766.1, NP_001177765.1, NP_001128513.1, NP_001128512.1

COSMIC

COSF1625

OpenTargets

ENSG00000204843

ENSEMBL

ENSP00000487724, ENST00000409438, ENST00000409567, ENST00000628224, ENSP00000387270, ENSP00000487279, ENSP00000377571, ENST00000394003, ENST00000409240, ENSG00000204843, ENSP00000386843, ENST00000633691, ENSP00000386406

Mondo

0006427

GeneCards

DCTN1

HPA

ENSG00000204843-DCTN1

PRO

Q14203

Pharos - Targets

Q14203

GlyGen

Q14203

Orphanet

DCTN1

PDB

1TXQ, 2HL3, 2HKN, 2COY, 2HQH, 2HKQ, 2HL5, 3E2U, 3TQ7

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15691 MAPRE1	1	MAPRE1 [cytosol] (R-HSA-376240)	0.9	9
UniProt:P47756 CAPZB	1	CAPZB [cytosol] (R-HSA-879409)	0.789	7
UniProt:Q13561 DCTN2	1	DCTN2 [cytosol] (R-HSA-380302)	0.779	9
UniProt:P61163 ACTR1A	1	ACTR1A [cytosol] (R-HSA-380258)	0.779	8
UniProt:O00399 DCTN6	1	DCTN6 [cytosol] (R-HSA-2029035)	0.779	9
UniProt:P30622-1 CLIP1			0.76	7
UniProt:Q9NZ32 ACTR10	4	ACTR10 [ficolin-1-rich granule lumen] (R-HSA-6801072) ACTR10 [extracellular region] (R-HSA-6806245) ACTR10 [azurophil granule lumen] (R-HSA-6801080) ACTR10 [cytosol] (R-HSA-6801556)	0.712	7
UniProt:O75935 DCTN3	1	DCTN3 [cytosol] (R-HSA-380264)	0.712	7
UniProt:Q9UJW0 DCTN4	1	DCTN4 [cytosol] (R-HSA-2029070)	0.712	7
UniProt:P47755 CAPZA2	2	CAPZA2(265-276) [extracellular region] (R-HSA-879417) CAPZA2 [cytosol] (R-HSA-879448)	0.706	7
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.704	9
UniProt:P42025 ACTR1B	4	ACTR1B [cytosol] (R-HSA-2228745) ACTR1B [ficolin-1-rich granule lumen] (R-HSA-6801063) ACTR1B [extracellular region] (R-HSA-6806503) ACTR1B [secretory granule lumen] (R-HSA-6801082)	0.65	6
UniProt:P54256 HAP1			0.646	4
UniProt:P52907 CAPZA1	2	CAPZA1 [cytosol] (R-HSA-879363) CAPZA1(265-276) [extracellular region] (R-HSA-879421)	0.638	3
UniProt:Q96RK4 BBS4	1	BBS4 [cytosol] (R-HSA-5617635)	0.635	3
UniProt:Q9BTE1 DCTN5	1	DCTN5 [cytosol] (R-HSA-2029012)	0.615	6
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.615	10
UniProt:Q14204 DYNC1H1	3	DYNC1H1 [cytosol] (R-HSA-380285) DYNC1H1 [azurophil granule lumen] (R-HSA-6799155) DYNC1H1 [extracellular region] (R-HSA-6806223)	0.615	3
UniProt:P30622 CLIP1	3	CLIP1 [cytosol] (R-HSA-377732) CLIP1(1-1083)-LTK(488-864) fusion [plasma membrane] (R-HSA-9842572) CLIP1(1-1083)-p-6Y LTK(488-864) fusion [plasma membrane] (R-HSA-9842573)	0.595	3
UniProt:O08788	1	Dctn1 [cytosol] (R-MMU-380301)	0.564	2
UniProt:Q99KJ8	1	Dctn2 [cytosol] (R-MMU-380302)	0.564	2
UniProt:Q9Z0Y1	1	Dctn3 [cytosol] (R-MMU-380264)	0.564	2
UniProt:Q9NRI5 DISC1			0.553	2
UniProt:Q9UNH7 SNX6			0.499	2
UniProt:Q13409 DYNC1I2	1	DYNC1I2 [cytosol] (R-HSA-201607)	0.483	2
UniProt:O75122 CLASP2	1	CLASP2 [cytosol] (R-HSA-376252)	0.483	2
UniProt:Q7Z460 CLASP1	1	CLASP1 [cytosol] (R-HSA-376230)	0.483	3
UniProt:P43034 PAFAH1B1	1	PAFAH1B1 [cytosol] (R-HSA-376249)	0.48	2
UniProt:Q6DN90 IQEC1			0.471	2
UniProt:Q9JK25	1	Clip1 [cytosol] (R-RNO-377732)	0.463	2
UniProt:Q8TCX1 DYNC2LI1	2	DYNC2LI1 [ciliary tip] (R-HSA-5625333) DYNC2LI1 [cilium] (R-HSA-5624862)	0.462	2

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