Reactome | ATP5B [mitochondrial matrix]

ATP5B [mitochondrial matrix]

Stable Identifier

R-HSA-164576

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

ATP synthase beta chain

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
    - Formation of ATP by chemiosmotic coupling (Homo sapiens)
      - ADP and Pi bind to ATPase (Homo sapiens)
        
        ATPase:ADP:Pi [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5B [mitochondrial matrix] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5B [mitochondrial matrix] (Homo sapiens)
      - ATPase synthesizes ATP (Homo sapiens)
        
        ATPase:ADP:Pi [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5B [mitochondrial matrix] (Homo sapiens)
        
        ATPase:ATP [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5B [mitochondrial matrix] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5B [mitochondrial matrix] (Homo sapiens)
      - Enzyme-bound ATP is released (Homo sapiens)
        
        ATPase:ATP [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5B [mitochondrial matrix] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5B [mitochondrial matrix] (Homo sapiens)

External Reference Information

External Reference

UniProt:P06576 ATP5F1B

Gene Names

ATP5F1B, ATP5B, ATPMB, ATPSB

Chain

transit peptide:1-47, chain:48-529

Reference Genes

BioGPS Gene:506 ATP5F1B

COSMIC (genes):ATP5F1B ATP5F1B

CTD Gene:506 ATP5F1B

dbSNP Gene:506 ATP5F1B

ENSEMBL:ENSG00000110955 ATP5B

HGNC:830 ATP5F1B

KEGG Gene (Homo sapiens):506 ATP5F1B

Monarch:506 ATP5F1B

NCBI Gene:506 ATP5F1B

OMIM:102910 ATP5F1B

Reference Transcript

RefSeq:NM_001686.3 ATP5F1B

Other Identifiers

0006860010

11724190_s_at

11757873_x_at

16766260

201322_at

3458034

3458035

3458036

3458037

3458039

3458040

3458041

3458042

3458045

3458047

3458048

3458050

3458054

506

7964234

A_23_P33216

GE57035

GO:0000166

GO:0001525

GO:0001649

GO:0003674

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005739

GO:0005743

GO:0005753

GO:0005754

GO:0005759

GO:0005886

GO:0006091

GO:0006754

GO:0006810

GO:0006811

GO:0007005

GO:0008150

GO:0009058

GO:0009986

GO:0015986

GO:0016020

GO:0016874

GO:0022857

GO:0030154

GO:0031966

GO:0032991

GO:0034641

GO:0040011

GO:0042288

GO:0042407

GO:0042592

GO:0042645

GO:0042776

GO:0043167

GO:0043226

GO:0043532

GO:0043536

GO:0044281

GO:0045259

GO:0045261

GO:0046034

GO:0046933

GO:0046961

GO:0048646

GO:0048856

GO:0048870

GO:0051453

GO:0055085

GO:0061024

GO:0070062

GO:1902600

HMNXSV003039648

ILMN_1772132

M19483_at

PH_hs_0019285

TC12001609.hg

g4502294_3p_at

Participates

as an output of

Expression of ATP5B (Homo sapiens)

as a component of

ATPase CF(1) [mitochondrial matrix] (Homo sapiens)

Other forms of this molecule

ATP5B [mitochondrial inner membrane]

ATP5B(1-47) [mitochondrial matrix]

ATP5B(1-529) [mitochondrial inner membrane]

ATP5B(1-529) [mitochondrial intermembrane space]

ATP5B(1-529) [cytosol]

Inferred To

atp-2 [mitochondrial matrix] (Caenorhabditis elegans)

Ghost homologue of ATP5B [mitochondrial matrix] (Canis familiaris)

ATP2 [mitochondrial matrix] (Saccharomyces cerevisiae)

atp5f1b [mitochondrial matrix] (Danio rerio)

ATP5B [mitochondrial matrix] (Bos taurus)

ATP5B [mitochondrial matrix] (Gallus gallus)

ATP5B [mitochondrial matrix] (Sus scrofa)

ATPsynbeta [mitochondrial matrix] (Drosophila melanogaster)

atp2 [mitochondrial matrix] (Schizosaccharomyces pombe)

Atp5f1b [mitochondrial matrix] (Mus musculus)

Atp5f1b [mitochondrial matrix] (Rattus norvegicus)

Cross References

RefSeq

NP_001677.2

Guide to Pharmacology - Targets

797

OpenTargets

ENSG00000110955

IntEnz

7.1.2.2

HPA

ENSG00000110955-ATP5F1B

GeneCards

P06576

Ensembl

ENST00000262030, ENSP00000262030, ENSG00000110955

PRO

P06576

Pharos - Targets

P06576

GlyGen

P06576

HMDB Protein

HMDBP01465

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N5M1 ATPF2			0.742	7
UniProt:P25705 ATP5F1A	3	ATP5A1 [mitochondrial matrix] (R-HSA-164575) ATP5A1(1-553) [cytosol] (R-HSA-1267955) ATP5A1(1-553) [mitochondrial intermembrane space] (R-HSA-1267978)	0.669	6
UniProt:P03372 ESR1	8	Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) ESR1 [cytosol] (R-HSA-9020968) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) PalmS-ESR1 [cytosol] (R-HSA-9020974) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302)	0.643	4
UniProt:Q9UII2 ATIF1			0.564	2
UniProt:P24539 ATP5PB	1	ATP5F1 [mitochondrial inner membrane] (R-HSA-164537)	0.564	3
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.564	2
UniProt:P54253 ATX1			0.556	3
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.556	3
UniProt:Q8N448 LNX2			0.553	4
UniProt:Q5TC12 ATPF1			0.547	2
UniProt:P25106 ACKR3	1	CXCR7 [plasma membrane] (R-HSA-373859)	0.527	2
UniProt:P51451 BLK	2	MyrG2-BLK [plasma membrane] (R-HSA-9606871) BLK [cytosol] (R-HSA-983580)	0.527	2
UniProt:A0A0F6B1Q8 A0A0F6B1Q8			0.462	2
UniProt:P05919 vpu	6	VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [plasma membrane] (R-HIV-3149423) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) protein [cytosol] (R-HIV-173223)	0.462	2