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p-PDIA6 [endoplasmic reticulum lumen]
Stable Identifier
R-HSA-8957031
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
Synonyms
PDIA6, Protein disulfide-isomerase A6 ecNumber5.3.4.1/ecNumber, PDIA6_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Post-translational protein phosphorylation (Homo sapiens)
FAM20C phosphorylates FAM20C substrates (Homo sapiens)
FAM20C:Phosphorylated FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)
p-PDIA6 [endoplasmic reticulum lumen] (Homo sapiens)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)
FAM20C phosphorylates FAM20C substrates (Homo sapiens)
FAM20C:Phosphorylated FAM20C substrates [endoplasmic reticulum lumen] (Homo sapiens)
FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)
p-PDIA6 [endoplasmic reticulum lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15084 PDIA6
Gene Names
PDIA6, ERP5, P5, TXNDC7
Chain
signal peptide:1-19, chain:20-440
Reference Genes
BioGPS Gene:10130 PDIA6
COSMIC (genes):PDIA6 PDIA6
CTD Gene:10130 PDIA6
dbSNP Gene:10130 PDIA6
ENSEMBL:ENSG00000143870 PDIA6
ENSEMBL:ENSG00000143870.13 PDIA6
HGNC:30168 PDIA6
KEGG Gene (Homo sapiens):10130 PDIA6
Monarch:10130 PDIA6
NCBI Gene:10130 PDIA6
OMIM:611099 PDIA6
UCSC:Q15084 PDIA6
Reference Transcript
RefSeq:NM_001282706.1 PDIA6
RefSeq:NM_005742.3 PDIA6
RefSeq:NM_001282705.1 PDIA6
RefSeq:NM_001282704.1 PDIA6
RefSeq:NM_001282707.1 PDIA6
Other Identifiers
10130
11715434_a_at
11745720_s_at
11749778_a_at
16894452
207668_PM_x_at
207668_x_at
208638_PM_at
208638_at
208639_PM_x_at
208639_x_at
216640_PM_s_at
216640_s_at
2540321
2540322
2540323
2540326
2540329
2540331
2540332
2540333
2540334
2540335
2540337
2540342
2540344
2540345
2540348
2540350
2540354
2540355
2540356
41750_at
74808_s_at
8050278
A_24_P319715
D49489_at
GE61375
GO:0003756
GO:0003824
GO:0005515
GO:0005576
GO:0005615
GO:0005783
GO:0005788
GO:0005789
GO:0005793
GO:0005829
GO:0005886
GO:0006457
GO:0015035
GO:0016020
GO:0016491
GO:0016853
GO:0031410
GO:0034663
GO:0034976
GO:0042470
GO:0043226
GO:0070062
GO:0140096
HMNXSV003029351
HMNXSV003040605
Hs.182429.1.S2_3p_at
Hs.182429.2.S1_3p_a_at
ILMN_1680626
PH_hs_0023080
TC02001573.hg
Participates
as a member of
FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)
Other forms of this molecule
PDIA6 [endoplasmic reticulum membrane]
PDIA6 [endoplasmic reticulum lumen]
Inferred To
phospho-Pdia6 [endoplasmic reticulum lumen]
(Mus musculus)
phospho-Pdia6 [endoplasmic reticulum lumen]
(Rattus norvegicus)
phospho-pdi-6 [endoplasmic reticulum lumen]
(Caenorhabditis elegans)
phospho-CaBP1 [endoplasmic reticulum lumen]
(Drosophila melanogaster)
phospho-PDIA6 [endoplasmic reticulum lumen]
(Bos taurus)
phospho-PDIA6 [endoplasmic reticulum lumen]
(Sus scrofa)
phospho-pdia6 [endoplasmic reticulum lumen]
(Xenopus tropicalis)
phospho-p-PDIA6 [endoplasmic reticulum lumen]
(Canis familiaris)
phospho-p-PDIA6 [endoplasmic reticulum lumen]
(Danio rerio)
phospho-p-PDIA6 [endoplasmic reticulum lumen]
(Gallus gallus)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Cross References
RefSeq
NP_001269634.1
,
NP_005733.1
,
NP_001269635.1
,
NP_001269633.1
,
NP_001269636.1
OpenTargets
ENSG00000143870
GeneCards
Q15084
HPA
ENSG00000143870-PDIA6
Ensembl
ENSP00000385385
,
ENST00000404824
,
ENSP00000438778
,
ENSP00000272227
,
ENSP00000384459
,
ENST00000272227
,
ENSG00000143870
,
ENST00000404371
,
ENST00000540494
,
ENST00000381611
,
ENSP00000481892
,
ENSP00000371024
,
ENST00000617249
PRO
Q15084
Pharos - Targets
Q15084
PDB
4EF0
,
1X5D
,
3VWW
,
4GWR
,
3W8J
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11021 HSPA5
6
HSPA5 [extracellular region]
(R-HSA-351322)
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
0.564
2
UniProt:Q96EQ0 SGTB
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:O43681 GET3
1
ASNA1 [cytosol]
(R-HSA-9609520)
0.556
3
UniProt:P48039 MTNR1A
1
MTNR1A [plasma membrane]
(R-HSA-419316)
0.527
2
UniProt:Q13618 CUL3
3
CUL3 [cytosol]
(R-HSA-975979)
CUL3 [nucleoplasm]
(R-HSA-5635033)
G76-NEDD8-K712-CUL3 [cytosol]
(R-HSA-8952516)
0.527
2
UniProt:P49286 MTNR1B
1
MTNR1B [plasma membrane]
(R-HSA-419349)
0.527
2
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.527
3
UniProt:Q13162 PRDX4
3
PRDX4 [secretory granule lumen]
(R-HSA-6803305)
PRDX4 [extracellular region]
(R-HSA-6806512)
PRDX4 [ficolin-1-rich granule lumen]
(R-HSA-6803286)
0.525
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
8
UniProt:P03366 POL
0.462
2
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